Home Cytoskeletal Signaling Microtubule Associated inhibitor iHAP1

research use only

iHAP1 Microtubule Associated inhibitor

Cat.No.S9695

iHAP1 is a well-established microtubule poison, blocks microtubule polymerization fully at 5 µM which is independent of deregulated transcription, causes marked sensitization when deleting Rod1 gene in HeLa cells.
iHAP1 Microtubule Associated inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 367.85

Jump to

Quality Control

Batch: S969501 DMSO]20 mg/mL]false]Ethanol]5 mg/mL]false]Water]Insoluble]false Purity: 99.84%
99.84

Solubility

In vitro
Batch:

DMSO : 20 mg/mL (54.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 367.85 Formula

C20H14ClNO2S

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 105925-39-1 -- Storage of Stock Solutions

Synonyms N/A Smiles COC1=CC=C(C=C1)C(=O)N2C3=CC=CC=C3SC4=C2C=C(Cl)C=C4

Mechanism of Action

Targets/IC50/Ki
microtubule polymerization
In vitro

The depletion of Rod1 and TACC3 results in sensitization to iHAP1, which is caused by chemogenic interaction between Rod1 and this compound. As for the RPE1‐hTERT P53−/− background, deletion of Rod1 in HeLa cells causes marked sensitization to this chemical.
References

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Signaling Pathway Map