TLR
Inhibitory Selectivity
TLR Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S8562 |
CA-4948CA-4948 is a reversible kinase inhibitor that modulates IRAK4 function in both the toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) signaling cascades, and demonstrates pharmacodynamic and antitumor activity in in vitro and in vivo nonclinical models. |
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| S7455New |
Resatorvid (TAK-242)Resatorvid (TAK-242) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α, IL-6, and IL-1β in macrophages with IC50 values of 1-11 nM. |
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| S6598New |
IRAK-1-4 Inhibitor IIRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor associated kinase (IRAK) with IC50 values of 0.3 μM and 0.2 μM for IRAK-1 and IRAK-4, respectively. It displays IC50 values >10 µM in a panel of 27 other kinases tested. |
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| S6719New |
E6446 (dihydrochloride)E6446 is a specific Toll-like receptor 9 inhibitor. |
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| S8677 |
Cu-CPT22CU-CPT22 shows dose-dependent inhibitory effects blocking Pam3CSK4-induced TLR1/2 activation with an IC50 of 0.58 ± 0.09 µM while no significant inhibition to TLR2/6. It demonstrates minimal non-specific inhibition against a panel of 10 representative kinases (PDGFRB, MET, DDR2, SRC, MAPK1, PAK1, AKT1, PKC-γ, CAMK1, and PLK4). |
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| S7221 |
GS-9620GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7. |
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| S8133 |
ResiquimodResiquimod is an immune response modifier that acts as a potent TLR 7/8 agonist. Phase 2. |
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| S8838New |
LHC165LHC165 is a TLR7 agonist designed for localized intratumoral therapies. |
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| S7161 |
Motolimod (VTX-2337)Motolimod (VTX-2337) is a selective and potent Toll-like receptor (TLR) 8 agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S8562 |
CA-4948CA-4948 is a reversible kinase inhibitor that modulates IRAK4 function in both the toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) signaling cascades, and demonstrates pharmacodynamic and antitumor activity in in vitro and in vivo nonclinical models. |
||
| S7455New |
Resatorvid (TAK-242)Resatorvid (TAK-242) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α, IL-6, and IL-1β in macrophages with IC50 values of 1-11 nM. |
||
| S6598New |
IRAK-1-4 Inhibitor IIRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor associated kinase (IRAK) with IC50 values of 0.3 μM and 0.2 μM for IRAK-1 and IRAK-4, respectively. It displays IC50 values >10 µM in a panel of 27 other kinases tested. |
||
| S6719New |
E6446 (dihydrochloride)E6446 is a specific Toll-like receptor 9 inhibitor. |
||
| S8677 |
Cu-CPT22CU-CPT22 shows dose-dependent inhibitory effects blocking Pam3CSK4-induced TLR1/2 activation with an IC50 of 0.58 ± 0.09 µM while no significant inhibition to TLR2/6. It demonstrates minimal non-specific inhibition against a panel of 10 representative kinases (PDGFRB, MET, DDR2, SRC, MAPK1, PAK1, AKT1, PKC-γ, CAMK1, and PLK4). |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S7221 |
GS-9620GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7. |
||
| S8133 |
ResiquimodResiquimod is an immune response modifier that acts as a potent TLR 7/8 agonist. Phase 2. |
||
| S8838New |
LHC165LHC165 is a TLR7 agonist designed for localized intratumoral therapies. |
||
| S7161 |
Motolimod (VTX-2337)Motolimod (VTX-2337) is a selective and potent Toll-like receptor (TLR) 8 agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2. |
