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Interleukins

Other Immunology & Inflammation Related Inhibitors

CXCR AhR STING COX IL Receptor gp120/CD4 NOD NADPH-oxidase ROS Nrf2

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S8879 BMS-986165 (Deucravacitinib) Deucravacitinib (BMS-986165) is a highly potent and selective allosteric inhibitor of Tyk2 with a Ki value of 0.02 nM for binding to the Tyk2 pseudokinase domain. It is highly selective against a panel of 265 kinases and pseudokinases.
Science China Life Sciences, 2025, 1-17
Res Sq, 2025, rs.3.rs-6079043
Nature Microbiology, 2024, 2553–2569
S8133 Resiquimod (R-848) Resiquimod (R-848, S28463) is an immune response modifier that acts as a potent TLR 7/TLR 8 agonist, inducing the upregulation of cytokines such as TNF-α, IL-6 and IFN-α. This compound reduces hepatitis C virus (HCV) infection. Phase 2.
Nature, 2025, 644(8078):1058-1068
J Virol, 2025, e0128025.
Int J Nanomedicine, 2024, 19:3589-3605
S1189 Aprepitant Aprepitant is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. This compound reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNFα. It inhibits HIV infection of human macrophages.
Br J Cancer, 2024, 10.1038/s41416-024-02608-8
Inflammation, 2023, 46(1):256-269
Nat Commun, 2022, 13(1):4995
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S1709 17β-Estradiol Estradiol (17β-estradiol, β-Estradiol, E2, 17β-Oestradiol) is a human sex hormone and steroid, and the primary female sex hormone. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
Cancer Cell, 2025, 43(5):891-904.e10
Nat Commun, 2025, 16(1):758
Cell Rep Med, 2025, 6(7):102192
S7124 SC144 SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.
Cell Rep Med, 2025, S2666-3791(25)00102-8
Respir Res, 2025, 26(1):285
bioRxiv, 2025, 2025.01.20.633954
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S8301 Ossirene (AS101) A potent in vitro and in vivo immunomodulator, Ossirene (AS101) is a novel inhibitor of IL-1beta converting enzyme.
International Journal of Oncology, May 21, 2019, 69-80
Journal of Inflammation Research, January 25, 2025, 1191-1205
Mol Neurodegener, 2025, 20(1):5
S4267 Diacerein Diacerein is an inhibitor of pro-inflammatory cytokine Interleukin-1B (IL-1B) production, prescribed for osteoarthritis and chronic inflammatory arthritis.
MedComm (2020), 2024, 5(8):e668
Molecular Cancer Research, 2022, 661-669
Oral Dis, 2022, 10.1111/odi.14294
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S0785 Apilimod mesylate Apilimod mesylate is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. This compound inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. It is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.
Nature Communications, June 28, 2024, 5487
Journal of Biological Chemistry, June 26, 2022, 102187
Cancer Research, April 15, 2025, 1479-1495
S9727 Ac-YVAD-cmk Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective IL-1β converting enzyme (ICE) inhibitor with neuroprotective and anti-inflammatory effects, effectively suppresses the expression of IL-1β and IL-18.
Cell Commun Signal, 2024, 22(1):368
J Transl Med, 2024, 22(1):1139
Int J Mol Sci, 2024, 25(4)2185
S0472 EC330 EC330 is a steroidal inhibitor of leukemia inhibitory factor (LIF, an interleukin 6 class cytokine). This compound inhibits the LIF/LIF-R signaling and blocks the promoting effects of LIF on growth and migration of cancer cells.
npj Precision Oncology, 2024, 246
NPJ Precis Oncol, 2024, 8(1):246
Br J Cancer, 2021, 10.1038/s41416-021-01631-3