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Interleukins

Other Immunology & Inflammation Related Inhibitors

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S8879 BMS-986165 (Deucravacitinib) Deucravacitinib (BMS-986165) is a highly potent and selective allosteric inhibitor of Tyk2 with a Ki value of 0.02 nM for binding to the Tyk2 pseudokinase domain. It is highly selective against a panel of 265 kinases and pseudokinases.
Res Sq, 2025, rs.3.rs-6079043
Nat Commun, 2024, 15(1):1718
Nat Commun, 2024, 15(1):1337
S8133 Resiquimod (R-848) Resiquimod (R-848, S28463) is an immune response modifier that acts as a potent TLR 7/TLR 8 agonist, inducing the upregulation of cytokines such as TNF-α, IL-6 and IFN-α. This compound reduces hepatitis C virus (HCV) infection. Phase 2.
Nature, 2025, 644(8078):1058-1068
J Virol, 2025, e0128025.
Int J Nanomedicine, 2024, 19:3589-3605
S1189 Aprepitant Aprepitant is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. This compound reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNFα. It inhibits HIV infection of human macrophages.
Br J Cancer, 2024, 10.1038/s41416-024-02608-8
Inflammation, 2023, 46(1):256-269
Nat Commun, 2022, 13(1):4995
Verified customer review of Aprepitant
S1709 17β-Estradiol Estradiol (17β-estradiol, β-Estradiol, E2, 17β-Oestradiol) is a human sex hormone and steroid, and the primary female sex hormone. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
Cancer Cell, 2025, 43(5):891-904.e10
Nat Commun, 2025, 16(1):758
Cell Rep Med, 2025, 6(7):102192
S7124 SC144 SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.
Cell Rep Med, 2025, S2666-3791(25)00102-8
Respir Res, 2025, 26(1):285
bioRxiv, 2025, 2025.01.20.633954
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S8301 Ossirene (AS101) A potent in vitro and in vivo immunomodulator, Ossirene (AS101) is a novel inhibitor of IL-1beta converting enzyme.
Mol Neurodegener, 2025, 20(1):5
Cell Biosci, 2025, 15(1):18
Stem Cell Rev Rep, 2025, none
S4267 Diacerein Diacerein is an inhibitor of pro-inflammatory cytokine Interleukin-1B (IL-1B) production, prescribed for osteoarthritis and chronic inflammatory arthritis.
MedComm (2020), 2024, 5(8):e668
Oral Dis, 2022, 10.1111/odi.14294
Free Radic Biol Med, 2021, 165:171-183
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S9727 Ac-YVAD-cmk Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective IL-1β converting enzyme (ICE) inhibitor with neuroprotective and anti-inflammatory effects, effectively suppresses the expression of IL-1β and IL-18.
Cell Commun Signal, 2024, 22(1):368
J Transl Med, 2024, 22(1):1139
Int J Mol Sci, 2024, 25(4)2185
S0785 Apilimod mesylate Apilimod mesylate is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. This compound inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. It is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.
bioRxiv, 2024, 2024.02.28.582543
Stem Cell Reports, 2022, 17(2):397-412
Hum Mol Genet, 2021, 29(22):3589-3605
S0472 EC330 EC330 is a steroidal inhibitor of leukemia inhibitory factor (LIF, an interleukin 6 class cytokine). This compound inhibits the LIF/LIF-R signaling and blocks the promoting effects of LIF on growth and migration of cancer cells.
NPJ Precis Oncol, 2024, 8(1):246
Br J Cancer, 2021, 10.1038/s41416-021-01631-3