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AhR Inhibitors/Activators | Agonists | Antagonists
AhR Products
- All (20)
- AhR Inhibitors (2)
- AhR Activator (1)
- AhR Antagonists (7)
- AhR Agonists (9)
- New AhR Products
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
|---|---|---|---|---|
| S1177 | PD98059 | PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2. This compound is a ligand for the aryl hydrocarbon receptor (AHR) and functions as an AHR antagonist. |
|
|
| S2929 | Pifithrin-α (PFTα) HBr | Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. Pifithrin-α is also a potent agonist of the aryl hydrocarbon receptor (AhR). |
|
|
| S7711 | CH-223191 | CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist with IC50 of 30 nM. |
|
|
| S2858 | SR1 (StemRegenin 1) | An aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay, SR1 (StemRegenin 1) is also known by this designation. |
|
|
| S1247 | Leflunomide | Leflunomide is a pyrimidine synthesis and protein tyrosine kinase inhibitor belonging to the DMARD, used as an immunosuppressant agent. The active metabolite of this compound is A77 1726, which inhibits dihydroorotate dehydrogenase (DHODH). This chemical is also an agonist of the AhR. |
|
|
| S9682 | FICZ | FICZ (6-Formylindolo[3,2-b]carbazole) is a potent agonist of aryl hydrocarbon receptor (AhR) that is efficiently metabolized by AHR-regulated cytochrome P4501 enzymes. | ||
| S8842 | BAY-218 | BAY-218 is a potent and selective small-molecule AhR inhibitor, inhibiting AhR nuclear translocation, dioxin response element (DRE)-luciferase reporter expression and AhR-regulated target gene expression induced by both exogenous and endogenous AhR ligands. | ||
| S9700 | Tapinarof | Tapinarof (GSK2894512, Benvitimod, WBI 1001, DHPS, DMVT 505) is a natural agonist of aryl hydrocarbon receptor (AhR) and induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT) with EC50 of 0.16 nM. This compound induces cellular apoptosis in CD4+ T cells in a dosedependent manner with IC50 of 5.2 μM. | ||
| S8995 | BAY 2416964 | BAY 2416964 (compound 192) is a potent and orally active antagonist of aryl hydrocarbon receptor (AhR) with IC50 of 341 nM. This compound has the potential in the treatment of solid tumors. | ||
| S6926 | GNF351 | GNF351 is a potent antagonist of aryl hydrocarbon receptor (AHR). This compound interacts directly with the AHR ligand binding pocket and competes with a well-characterized photoaffinity AHR ligand for binding to the AHR with IC50 of 62 nM. | ||
| S5839 | L-Kynurenine | L-Kynurenine ((S)-Kynurenine) is a aryl hydrocarbon receptor agonist. This compound is a metabolite of the amino acid L-tryptophan used in the production of niacin and a central compound of the tryptophan metabolism pathway. | ||
| F0827 | AhR Antibody [A3L23] | Ah Receptor,AhR,Aryl hydrocarbon Receptor | ||
| S2292 | Diosmin | Diosmin is an agonist of the aryl hydrocarbon receptor (AhR). This compound is a semisynthetic phlebotropic agent and a flavonoid found in a variety of citrus fruits. | ||
| S6560 | PDM2 | PDM2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist. | ||
| S0154 | CAY10465 | CAY 10465 is a selective and high-affinity agonist on aryl hydrocarbon receptor (AhR) with Ki of 0.2 nM. | ||
| S0155 | PDM-11 | PDM-11 is a derivative of resveratrol that exhibits stronger antagonist affinity for arylhydrocarbon receptors (AhR) than resveratrol, without any affinity for the estrogen receptor. | ||
| E5768 | Indolelactic acid | Indolelactic acid (Indole-3-lactic acid), a metabolite of tryptophan (Trp), plays a role in immune cell differentiation and cytokine production by activating aryl hydrocarbon receptors (AhR). This regulation supports immune responses and aids in anti-inflammatory and anti-allergic activities. It also plays an important role in the balance of Th17/Treg cells by reprogramming CD4+ Th cells into CD4+CD8+ Treg cells and inhibiting the polarization of Th17 cells. | ||
| S9092 | Norisoboldine | Norisoboldine (Laurelliptine), a natural aryl hydrocarbon receptor (AhR) agonist, attenuates ulcerative colitis (UC) and induces the generation of Treg cells. | ||
| S3205 | Perillaldehyde | Perillaldehyde (Perilladehyde, Perillal, PAE, PA), the main component of Perilla frutescens (a traditional medicinal antioxidant herb), inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway. | ||
| E0143 | ITE | ITE (2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester) is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) that directly binds to AHR with a Ki of 3 nM. |
||
| S8842 | BAY-218 | BAY-218 is a potent and selective small-molecule AhR inhibitor, inhibiting AhR nuclear translocation, dioxin response element (DRE)-luciferase reporter expression and AhR-regulated target gene expression induced by both exogenous and endogenous AhR ligands. | ||
| S3205 | Perillaldehyde | Perillaldehyde (Perilladehyde, Perillal, PAE, PA), the main component of Perilla frutescens (a traditional medicinal antioxidant herb), inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway. | ||
| E5768 | Indolelactic acid | Indolelactic acid (Indole-3-lactic acid), a metabolite of tryptophan (Trp), plays a role in immune cell differentiation and cytokine production by activating aryl hydrocarbon receptors (AhR). This regulation supports immune responses and aids in anti-inflammatory and anti-allergic activities. It also plays an important role in the balance of Th17/Treg cells by reprogramming CD4+ Th cells into CD4+CD8+ Treg cells and inhibiting the polarization of Th17 cells. | ||
| S1177 | PD98059 | PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2. This compound is a ligand for the aryl hydrocarbon receptor (AHR) and functions as an AHR antagonist. |
|
|
| S7711 | CH-223191 | CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist with IC50 of 30 nM. |
|
|
| S2858 | SR1 (StemRegenin 1) | An aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay, SR1 (StemRegenin 1) is also known by this designation. |
|
|
| S8995 | BAY 2416964 | BAY 2416964 (compound 192) is a potent and orally active antagonist of aryl hydrocarbon receptor (AhR) with IC50 of 341 nM. This compound has the potential in the treatment of solid tumors. | ||
| S6926 | GNF351 | GNF351 is a potent antagonist of aryl hydrocarbon receptor (AHR). This compound interacts directly with the AHR ligand binding pocket and competes with a well-characterized photoaffinity AHR ligand for binding to the AHR with IC50 of 62 nM. | ||
| S6560 | PDM2 | PDM2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist. | ||
| S0155 | PDM-11 | PDM-11 is a derivative of resveratrol that exhibits stronger antagonist affinity for arylhydrocarbon receptors (AhR) than resveratrol, without any affinity for the estrogen receptor. | ||
| S2929 | Pifithrin-α (PFTα) HBr | Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. Pifithrin-α is also a potent agonist of the aryl hydrocarbon receptor (AhR). |
|
|
| S1247 | Leflunomide | Leflunomide is a pyrimidine synthesis and protein tyrosine kinase inhibitor belonging to the DMARD, used as an immunosuppressant agent. The active metabolite of this compound is A77 1726, which inhibits dihydroorotate dehydrogenase (DHODH). This chemical is also an agonist of the AhR. |
|
|
| S9682 | FICZ | FICZ (6-Formylindolo[3,2-b]carbazole) is a potent agonist of aryl hydrocarbon receptor (AhR) that is efficiently metabolized by AHR-regulated cytochrome P4501 enzymes. | ||
| S9700 | Tapinarof | Tapinarof (GSK2894512, Benvitimod, WBI 1001, DHPS, DMVT 505) is a natural agonist of aryl hydrocarbon receptor (AhR) and induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT) with EC50 of 0.16 nM. This compound induces cellular apoptosis in CD4+ T cells in a dosedependent manner with IC50 of 5.2 μM. | ||
| S5839 | L-Kynurenine | L-Kynurenine ((S)-Kynurenine) is a aryl hydrocarbon receptor agonist. This compound is a metabolite of the amino acid L-tryptophan used in the production of niacin and a central compound of the tryptophan metabolism pathway. | ||
| S2292 | Diosmin | Diosmin is an agonist of the aryl hydrocarbon receptor (AhR). This compound is a semisynthetic phlebotropic agent and a flavonoid found in a variety of citrus fruits. | ||
| S0154 | CAY10465 | CAY 10465 is a selective and high-affinity agonist on aryl hydrocarbon receptor (AhR) with Ki of 0.2 nM. | ||
| S9092 | Norisoboldine | Norisoboldine (Laurelliptine), a natural aryl hydrocarbon receptor (AhR) agonist, attenuates ulcerative colitis (UC) and induces the generation of Treg cells. | ||
| E0143 | ITE | ITE (2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester) is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) that directly binds to AHR with a Ki of 3 nM. |
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