Vicriviroc maleate

Catalog No.S3494 Synonyms: SCH-417690 maleate, SCH-D maleate

For research use only.

Vicriviroc maleate(SCH-417690 maleate,SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells.

Vicriviroc maleate Chemical Structure

CAS No. 599179-03-0

Selleck's Vicriviroc maleate has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Vicriviroc maleate(SCH-417690 maleate,SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells.
Targets
HIV-1 [1] CCR5 [1]
(in PK assays)
2.5 nM(Ki)

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 649.7
Formula

C32H42F3N5O6

CAS No. 599179-03-0
Storage 3 years -20°C powder
2 years -80°C in solvent

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03631407 Completed Drug: Vicriviroc|Biological: Pembrolizumab Colorectal Neoplasms Merck Sharp & Dohme LLC September 24 2018 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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