| S5816 |
Pyrvinium pamoate
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Pyrvinium pamoate(Pyrvinium embonate) is an anthelmintic effective for pinworms.
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Journal of Experimental & Clinical Cancer Research, October 1, 2025, 278
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Antimicrobial Agents and Chemotherapy, March 27, 2018, e02361-17
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Anticancer Research, March 2024, 44(3):1193-1199
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| S4610 |
Mebendazole
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Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent. This compound interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake.
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Genome Medicine, September 07 2021, 146
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Molecules, November 22, 2022, 8127
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bioRxiv, November 04 2025, nan
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| S5948 |
Amodiaquine
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Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.
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Molecules, March 19, 2024, 1363
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Cell Death Discov, 2024, 10(1):434
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Molecules, 2024, 29(6)1363
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| S4104 |
Diminazene Aceturate
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Diminazene(Diminazene diaceturate) is a di-amidine also known as 4,4-(1-Triazene–1,3–diyl)bis(benzenecarboximidamide), used as an effective trypanocidal agent. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties.
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Scientific Reports, 2025, 18633
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Sci Rep, 2025, 15(1):18633
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Cell, 2024, 4095-4112.e21
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| S1691 |
Praziquantel
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Praziquantel is an anthelmintic effective against flatworms.
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PLOS Neglected Tropical Diseases, September 21, 2017, e0005942
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Communications Medicine, 2025, 420
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bioRxiv, 2023, 2023.07.12.548707
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| S4068 |
Tinidazole
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Tinidazole (CP12574) is an anti-parasitic drug.
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Cancer Res Commun, 2025, 10.1158/2767-9764.CRC-24-0433
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International Journal of Molecular Sciences, 2024, 4413
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Int J Mol Sci, 2024, 25(8)4413
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| S1830 |
Oxfendazole
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Oxfendazole (RS-8858,Fenbendazole sulfoxide) is a broad spectrum benzimidazole anthelmintic.
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bioRxiv, 2023, 2023.07.12.548707
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Nature Cell Biology, 2019, 203-213
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Molecular Medicine Reports, 2019, 2921-2926
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| S1851 |
Oxibendazole
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Oxibendazole is a benzimidazole drug that interferes with metabolic pathways, used to protect against roundworms, strongyles, threadworms, pinworms and lungworm infestations in horses and some domestic pets.
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J Control Release, 2025, 380:417-432
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Oncology Letters, 2018, 2218-2226
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Oncol Lett, 2018, 15(2):2218-2226
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| S3741 |
Benznidazole
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Benznidazole (Radanil) is a nitroimidazole derivative having an antiprotozoal activity by interfering with parasite protein biosynthesis, influencing cytokines production and stimulating host phagocytosis.
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Int J Mol Sci, 2024, 25(8)4413
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Microorganisms, 2022, 10(7)1421
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| S5345 |
(+/-)-nerolidol
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(+/-)-nerolidol (Peruviol) is a naturally occurring sesquiterpene found in the essential oils of many types of plants and flowers. It has diverse range of pharmacological and biological activities including antioxidant, anti-microbial, anti-biofilm, anti-parasitic, insecticidal, anti-ulcer, skin penetration enhancer, anti-tumor, anti-nociceptive and anti-inflammatory properties.
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Life, 2023, 1112
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Int Immunopharmacol, 2020, 80:106118
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