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NLRP3

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Cat.No. Product Name Information Product Use Citations Product Validations
S7809 MCC950 Sodium MCC950 Sodium is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.
J Exp Med, 2025, 222(11)e20242403
EMBO Mol Med, 2025, 10.1038/s44321-025-00251-1
Cell Death Dis, 2025, 16(1):565
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S8930 MCC950 MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.
Signal Transduct Target Ther, 2025, 10(1):157
Cell Stem Cell, 2025, 32(11):1671-1690.e13
J Exp Med, 2025, 222(11)e20242403
S5774 CY-09 CY-09 is a specific NLRP3 inflammasome inhibitor that directly targeted NLRP3 itself. It is tested against the five major cytochrome P450 enzymes 1A2, 2C9, 2C19, 2D6, and 3A4 with half maximal inhibitory concentration (IC50) values of 18.9, 8.18, >50, >50, and 26.0 µM, respectively.
Cell Death Dis, 2025, 16(1):252
Ecotoxicol Environ Saf, 2024, 290:117549
iScience, 2024, 27(3):109118
S8559 INF39 INF39 is a nontoxic, irreversible NLRP3 inhibitor that counteracts NLRP3 activation through direct irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression.
Chin Med J (Engl), 2022, 135(12):1474-1485
Biomed Res Int, 2022, 2022:7250578
Int Immunopharmacol, 2021, 92:107358
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S3680 NLRP3 Inflammasome Inhibitor I NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.
BMC Gastroenterol, 2025, 25(1):23
eprints, 2023, 10.14943/doctoral.k15475
Am J Pathol, 2022, S0002-9440(22)00076-1
S8907 Dapansutrile Dapansutrile is a novel and selective NLRP3 inflammasome inhibitor.
iScience, 2023, 26(3):106089
iScience, 2023, 26(3):106089
E0138 YQ128

YQ128 is a selective inhibitor of NLRP3 with an IC50 of 0.30 µM.
E1940New NT-0796 NT-0796 is a brain-penetrant and highly potent inhibitor of NLRP3 Inflammasome with a potential for treating neuroinflammatory disorders. It inhibits IL-1β release in human PBMC cells with an IC50 value of 0.32 nM.
S9899 BMS-986299

BMS-986299 is a novel NLRP3 agonist that induces IL8 release to activate natural killer (NK) cells.
E1970 BAL-0028 BAL-0028 (Compound 3), which belongs to the indazole class is an inhibitor of NLRP3 activation with an IC50 value of 25 nM. This compound binds tightly to the NACHT domain of NLRP3, with KD values ranging from 104 to 123 nM. It also exhibits anti-inflammatory activity.
Sci Rep, 2025, 15(1):6149