NLRP3

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NLRP3 Products

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  • NLRP3 Inhibitors (11)
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  • New NLRP3 Products
Catalog No. Product Name Information Product Use Citations Product Validations
E0138New YQ128

YQ128 is a selective inhibitor of NLRP3 with an IC50 of 0.30 µM.

S3290 Procyanidin B2 Procyanidin B2 (PCB2), a natural flavonoid found in commonly consumed foods, possess anti-inflammatory, anti-oxidant and anti-cancer activities. Procyanidin B2 activates PPARγ to induce M2 polarization in mouse macrophages. Procyanidin B2 significantly suppresses the activation of NLRP3 inflammasome in the lung tissue induced by paraquat in the rat model.
S3680 NLRP3 Inflammasome Inhibitor I NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.
Am J Pathol, 2022, S0002-9440(22)00076-1
Immunopharmacol Immunotoxicol, 2022, 1-24
Front Pharmacol, 2021, 12:627557
S3871 Muscone Muscone (3-Methylcyclopentadecanone, Methylexaltone), a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent. Muscone significantly downregulats the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in BMDMs. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6).
J Pharm Pharmacol, 2019, 71(11):1706-1713
S3939 4'-Methoxyresveratrol 4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
S5774 CY-09 CY-09 is a specific NLRP3 inflammasome inhibitor that directly targeted NLRP3 itself。 It is tested against the five major cytochrome P450 enzymes 1A2, 2C9, 2C19, 2D6, and 3A4 with half maximal inhibitory concentration (IC50) values of 18.9, 8.18, >50, >50, and 26.0 µM, respectively.
J Exp Clin Cancer Res, 2022, 41(1):74
J Reprod Immunol, 2022, 150:103488
Biochem Biophys Res Commun, 2021, 553:119-125
S7809 MCC950 Sodium (CP-456773 Sodium) MCC950 Sodium (CP-456773 Sodium, CRID3 sodium salt) is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.
Oxid Med Cell Longev, 2022, 2022:2566917
Am J Transplant, 2022, 10.1111/ajt.16968
Cell Death Dis, 2022, 13(1):38
S8559 INF39 INF39 is a nontoxic, irreversible NLRP3 inhibitor that counteracts NLRP3 activation through direct irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression.
Int Immunopharmacol, 2021, 92:107358
Cell Biol Int, 2020, 10.1002/cbin.11429
Mediators Inflamm, 2019, 2019:1082497
S8907 Dapansutrile Dapansutrile is a novel and selective NLRP3 inflammasome inhibitor.
S8930 MCC950 MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.
Cell Rep, 2022, 38(11):110507
Am J Transplant, 2022, 10.1111/ajt.16968
Cells, 2022, 11(10)1630
S9261New Shionone

Shionone is a triterpenoid component derived from the herbal medicine Aster tataricus, anit has anti-inflammatory properties. Shionone specifically inhibits NLRP3 inflammasome activation in vitro and in vivo.

S6653 Nigericin (NSC 292567) sodium salt Nigericin (NSC 292567) sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.
J Hazard Mater, 2022, 436:129093
Biomed Pharmacother, 2022, 150:112978
Oxid Med Cell Longev, 2022, 2022:1733834
S9899New BMS-986299

BMS-986299 is a novel NLRP3 agonist that induces IL8 release to activate natural killer (NK) cells.

E0225New Licochalcone B

Licochalcone B (Lico B), extracted from Glycyrrhiza uralensis Fisch, induces the cell cycle arrest and apoptosis in human hepatoma cell HepG2. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.

E1281New Dimethyl itaconate Dimethyl itaconate can reprogram neurotoxic to neuroprotective primary astrocytes through the regulation of LPS-induced Nod-like receptor protein 3 (NLRP3) inflammasome and nuclear factor 2/heme oxygenase-1 (NRF2/HO-1) pathways.
E0138New YQ128

YQ128 is a selective inhibitor of NLRP3 with an IC50 of 0.30 µM.

S3290 Procyanidin B2 Procyanidin B2 (PCB2), a natural flavonoid found in commonly consumed foods, possess anti-inflammatory, anti-oxidant and anti-cancer activities. Procyanidin B2 activates PPARγ to induce M2 polarization in mouse macrophages. Procyanidin B2 significantly suppresses the activation of NLRP3 inflammasome in the lung tissue induced by paraquat in the rat model.
S3680 NLRP3 Inflammasome Inhibitor I NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.
Am J Pathol, 2022, S0002-9440(22)00076-1
Immunopharmacol Immunotoxicol, 2022, 1-24
Front Pharmacol, 2021, 12:627557
S3871 Muscone Muscone (3-Methylcyclopentadecanone, Methylexaltone), a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent. Muscone significantly downregulats the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in BMDMs. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6).
J Pharm Pharmacol, 2019, 71(11):1706-1713
S3939 4'-Methoxyresveratrol 4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
S5774 CY-09 CY-09 is a specific NLRP3 inflammasome inhibitor that directly targeted NLRP3 itself。 It is tested against the five major cytochrome P450 enzymes 1A2, 2C9, 2C19, 2D6, and 3A4 with half maximal inhibitory concentration (IC50) values of 18.9, 8.18, >50, >50, and 26.0 µM, respectively.
J Exp Clin Cancer Res, 2022, 41(1):74
J Reprod Immunol, 2022, 150:103488
Biochem Biophys Res Commun, 2021, 553:119-125
S7809 MCC950 Sodium (CP-456773 Sodium) MCC950 Sodium (CP-456773 Sodium, CRID3 sodium salt) is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.
Oxid Med Cell Longev, 2022, 2022:2566917
Am J Transplant, 2022, 10.1111/ajt.16968
Cell Death Dis, 2022, 13(1):38
S8559 INF39 INF39 is a nontoxic, irreversible NLRP3 inhibitor that counteracts NLRP3 activation through direct irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression.
Int Immunopharmacol, 2021, 92:107358
Cell Biol Int, 2020, 10.1002/cbin.11429
Mediators Inflamm, 2019, 2019:1082497
S8907 Dapansutrile Dapansutrile is a novel and selective NLRP3 inflammasome inhibitor.
S8930 MCC950 MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.
Cell Rep, 2022, 38(11):110507
Am J Transplant, 2022, 10.1111/ajt.16968
Cells, 2022, 11(10)1630
S9261New Shionone

Shionone is a triterpenoid component derived from the herbal medicine Aster tataricus, anit has anti-inflammatory properties. Shionone specifically inhibits NLRP3 inflammasome activation in vitro and in vivo.

S6653 Nigericin (NSC 292567) sodium salt Nigericin (NSC 292567) sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.
J Hazard Mater, 2022, 436:129093
Biomed Pharmacother, 2022, 150:112978
Oxid Med Cell Longev, 2022, 2022:1733834
S9899New BMS-986299

BMS-986299 is a novel NLRP3 agonist that induces IL8 release to activate natural killer (NK) cells.

E0138New YQ128

YQ128 is a selective inhibitor of NLRP3 with an IC50 of 0.30 µM.

S9261New Shionone

Shionone is a triterpenoid component derived from the herbal medicine Aster tataricus, anit has anti-inflammatory properties. Shionone specifically inhibits NLRP3 inflammasome activation in vitro and in vivo.

S9899New BMS-986299

BMS-986299 is a novel NLRP3 agonist that induces IL8 release to activate natural killer (NK) cells.

E0225New Licochalcone B

Licochalcone B (Lico B), extracted from Glycyrrhiza uralensis Fisch, induces the cell cycle arrest and apoptosis in human hepatoma cell HepG2. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.

E1281New Dimethyl itaconate Dimethyl itaconate can reprogram neurotoxic to neuroprotective primary astrocytes through the regulation of LPS-induced Nod-like receptor protein 3 (NLRP3) inflammasome and nuclear factor 2/heme oxygenase-1 (NRF2/HO-1) pathways.
Tags: NLRP3 inhibitor|NLRP3 agonist|NLRP3 activator|NLRP3 inducer|NLRP3 antagonist|NLRP3 signaling pathway|NLRP3 assay kit