Home Immunology & Inflammation NOS

NOS

Other Immunology & Inflammation Related Inhibitors

CXCR AhR STING COX IL Receptor gp120/CD4 NOD NADPH-oxidase ROS Nrf2

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S2877 L-NAME HCl L-NAME HCl (NG-Nitroarginine methyl ester, N-Nitro-L-arginine methylester) is a nonselective inhibitor of nitric oxide synthetases (NOS) for nNOS (bovine), eNOS (human), and iNOS (murine), with Ki of 15 nM, 39 nM and 4.4 μM, respectively. This compound can be used to induce animal models of Hypertension.
PLoS Pathog, 2025, 21(4):e1012561
Commun Biol, 2025, 8(1):201
Nat Neurosci, 2024, 10.1038/s41593-024-01604-8
Verified customer review of L-NAME HCl
S8337 1400W 2HCl 1400W (N-(3-(Aminomethyl)benzyl)acetamidine) is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase(iNOS).
Nat Commun, 2025, 16(1):3570
Biomolecules, 2025, 15(1)125
Nat Commun, 2024, 15(1):2698
S4548 Aminoguanidine hydrochloride Aminoguanidine (Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine) is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone.
Anim Biotechnol, 2021, 1-10
Anim Biotechnol, 2021, 1-8
Am J Cancer Res, 2020, 10(5):1400-1415
S3174 L-Arginine HCl (L-Arg) L-Arginine HCl (L-Arg, (S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis. This compound can be used to induce animal models of Acute Pancreatitis.
J Immunother Cancer, 2024, 12(11)e009805
Am J Cancer Res, 2021, 11(2):590-617
J Cell Mol Med, 2018, 10.1111/jcmm.13532
S6962 TPEN

TPEN (TPEDA) is a specific cell-permeable heavy metal chelator that induces apoptosis in NB4 cells via negatively regulating intracellular NO and Zn2+ signaling. This compound may be a potential therapeutic strategy for APL (acute promyelocytic leukemia). It induces DNA damage and increases intracellular ROS production and also inhibits cell proliferation.
J Cachexia Sarcopenia Muscle, 2025, 16(2):e13771
J Biol Chem, 2025, 301(10):110653
Biomaterials, 2021, 271:120720
S3292 (3R,8S)-Falcarindiol Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.
Antioxidants (Basel), 2024, 13(12)1533
Front Cell Infect Microbiol, 2023, 13:1128000
Front Pharmacol, 2021, 12:656697
S7920 L-NMMA acetate L-NMMA acetate (Tilarginine Acetate, Methylarginine acetate, NG-Monomethyl-L-arginine acetate, L-NG-monomethyl Arginine acetate) is an acetate salt form of L-NMMA. L-NMMA is a nitric oxide synthase(NOS) inhibitor with an IC50 of 4.1 μM for nNOS.
Stem Cell Res Ther, 2024, 15(1):366
Spectrochim Acta A Mol Biomol Spectrosc, 2022, 277:121280
S9374 2',5'-Dihydroxyacetophenone 2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers is used in food flavouring. This compound significantly inhibits NO production via the suppression of iNOS expression. It significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways.
Pathol Oncol Res, 2019, 25(1):301-309
S5671 Amcinonide Amcinonide (Cyclocort, CL-34699) is an inhibitor of nitric oxide (NO) release from activated microglia with IC50 of 3.38 nM.
E0496 ZLc002 ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain.