HIV

Other Microbiology Related Inhibitors

Integrase Reverse Transcriptase Anti-infection Ribosomal Peptidyl Transferase COVID-19 3C-Like Protease β-lactamase Parasite Neuraminidase CMV

Cat.No.	Product Name	Information	Product Use Citations
S1208	Doxorubicin (Adriamycin) Hydrochloride	Doxorubicin (DOX) HCl is an antibiotic agent that inhibits human DNA topoisomerase II with IC50 of 2.67 μM. Doxorubicin reduces basal phosphorylation of AMPK. Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.This product may precipitate when dissolved in PBS solution. It is recommended to prepare the stock solution in pure water and dilute with either pure water or saline to obtain the working solution.Doxorubicin (Adriamycin) HCl can be used to induce animal models of kidney disease.	Cell Res, 2025, 35(6):437-452. Nat Commun, 2025, 16(1):8873 Nat Commun, 2025, 16(1):509
S1209	5-Fluorouracil (5-FU)	5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.	Nature, 2025, 10.1038/s41586-025-08974-4 Cancer Cell, 2025, S1535-6108(25)00223-5 Cell Stem Cell, 2025, S1934-5909(25)00265-6
S8030	AMD3100 (Plerixafor)	Plerixafor (AMD3100, JM 3100, SID791) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor inhibits human immunodeficiency virus (HIV) replication.	Theranostics, 2025, 15(18):9819-9837 Cell Mol Life Sci, 2025, 82(1):280 iScience, 2025, 28(1):111564
S7311	Q-VD-Oph	Q-VD-Oph (Quinoline-Val-Asp-Difluorophenoxymethylketone) is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1,3,8, and 9. Q-VD-OPh can inhibits HIV infection.	Nature, 2025, 10.1038/s41586-025-09754-w Signal Transduct Target Ther, 2025, 10(1):368 Nat Immunol, 2025, 26(11):1946-1961
S2003	Maraviroc (UK-427857)	Maraviroc is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM in cell-free assays, respectively. Maraviroc is used in the treatment of HIV infection.	Nat Commun, 2025, 16(1):4591 Adv Sci (Weinh), 2025, 12(8):e2411711 J Nanobiotechnology, 2025, 23(1):696
S1896	Hydroxyurea	Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection.	J Exp Med, 2025, 222(3)e20241248 Antimicrob Agents Chemother, 2025, e0047125. Invest Ophthalmol Vis Sci, 2025, 66(5):42
S1189	Aprepitant	Aprepitant is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. This compound reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNFα. It inhibits HIV infection of human macrophages.	Br J Cancer, 2024, 10.1038/s41416-024-02608-8 Inflammation, 2023, 46(1):256-269 Nat Commun, 2022, 13(1):4995
S6676	Ebselen	Ebselen (DR 3305, SPI-1005, PZ-51, CCG-39161) is a small-molecule capsid inhibitor of HIV-1 Replication with IC50 of 46.1 nM in TR-FRET assay.	Evid Based Complement Alternat Med, 2023, 2023:8378581 Science, 2022, 375(6586):1254-1261 NPJ Digit Med, 2022, 5(1):83
E3863	Swertia Bimaculata Extract	Swertia Bimaculata Extract is extracted from Swertia bimaculata, which is anti-inflammatory and anti-HIV.
S0958	Zingibroside R1	Zingibroside R1, isolated from rhizomes of Panax zingiberensis Wu et Feng (Araliaceae), has some anti-HIV-1 activity. This compound shows the inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells with IC50 of 91.3 µM and the growth of MT-4 cells with CC50 of 46.2 µM.