STING

STING Products

  • All (24)
  • STING Inhibitors (7)
  • STING Activators (2)
  • STING Antagonists (2)
  • STING Agonists (11)
  • New STING Products
Catalog No. Product Name Information Product Use Citations Product Validations
S1113 GSK690693 GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1.
Front Cell Infect Microbiol, 2025, 15:1543186
Biomol Ther (Seoul), 2025, 33(1):170-181
EMBO J, 2024, 10.1038/s44318-024-00244-9
S1537 Vadimezan (DMXAA) Vadimezan (DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.
Cell Chem Biol, 2025, 32(2):280-290.e14
Front Pharmacol, 2025, 16:1528459
Immun Inflamm Dis, 2025, 13(1):e70139
S6575 C-176 STING inhibitor C-176 is a potent, small-molecule inhibitor of STING, a central signaling component of the intracellular DNA sensing pathway.
Nat Commun, 2025, 16(1):289
Aging Cell, 2025, e70135
Mol Pharm, 2025, 10.1021/acs.molpharmaceut.4c01297
S6494 CCCP CCCP (Carbonyl cyanide m-chlorophenyl hydrazone, Carbonyl cyanide 3-chlorophenylhydrazone), an oxidative phosphorylation inhibitor, is a protonophore mitochondrial uncoupler that increases membrane permeability to protons, leading to a disruption in the mitochondrial membrane potential. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP), the protonophore, can inhibits STING-mediated IFN-β production via disrupting mitochondrial membrane potential (MMP).
Mol Cell, 2025, 85(7):1467-1476.e6
iScience, 2025, 28(8):112972
Vet Microbiol, 2025, 303:110427
S6652 H-151 H-151 is a highly potent and covalent inhibitor of STING that has noteworthy inhibitory activity both in human cells and in vivo.
Clin Transl Med, 2025, 15(3):e70235
J Neuroinflammation, 2025, 22(1):14
Biomed Pharmacother, 2025, 186:117991
S8796 diABZI STING agonist (Compound 3) diABZI STING agonist (diABZI STING agonist-1, Compound 3, Tautomerism) is a potent non-nucleotide STING agonist and has tremendous potential to improve treatment of cancer in humans.Solutions are unstable and should be fresh-prepared.
Cell Discov, 2025, 11(1):23
Nat Biomed Eng, 2025, 10.1038/s41551-025-01400-0
J Exp Med, 2025, 222(5)e20241184
S0853 SR-717 lithium SR-717 lithium is a non-nucleotide STING agonist that demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 (cGAS KO) cell lines, respectively. SR-717 lithium also induces the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. SR-717 lithium exhibits antitumor activity.
Nat Commun, 2025, 16(1):3440
Pharmaceutics, 2024, 16(9)1216
Mol Neurobiol, 2022, 59(11):7006-7024
S6667 STING inhibitor C-178 C-178 is a covalent inhibitor of STING,covalently bind to Cys91.
Neurosci Lett, 2025, 847:138095
Research Square, 2023, Version 2
Cell Chem Biol, 2022, 29(10):1517-1531.e7
E0128 C-171

C-171 is a covalent small-molecule inhibitor of STING. C-171 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING.

Cell Reports, 2023, 112328
Cell Rep, 2023, 42(4):112328
S8954 G10 (STING agonist-1) G10 (STING agonist-1) is a novel human-specific STING agonist that triggers IFN regulatory factor 3 (IRF3)/ type I interferon (IFN)-associated transcription in human fibroblasts. STING agonist-1 (G10) potently reduces growth of Chikungunya virus (CHIKV) with IC90 of 8.01 μM and blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM.
Int J Biol Sci, 2023, 19(11):3428-3440
S3804 Alpha-Mangostin Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING.
Int J Mol Sci, 2024, 25(13)7378
Front Pharmacol, 2021, 12:692806
S9681 MSA-2 MSA-2 is an orally available non-nucleotide human STING agonist with antitumor activity.
J Colloid Interface Sci, 2025, 686:1019-1032
Cell Discov, 2022, 8(1):133
F0361 STING Rabbit mAb STING,STING/TMEM173
F2884New STING (F1N19) Rabbit mAb
E1787 SN-001 SN-001 is a potent inhibitor of STING that specifically inhibits STING activation and STING-dependent signaling. SN-011 significantly decreases inflammatory cytokine production and osteoclast formation in vivo.
E5921New ZSA-51 ZSA-51 is a potent oral agonist of STING. It exhibits potent antitumor efficacy in colon and pancreatic cancer, with superior oral PK, low toxicity, and immune microenvironment remodeling in tumors and lymph nodes.
S9618 E7766 diammonium salt E7766 diammonium salt, a macrocycle-bridged STING agonist with a Kd of 40 nM, shows potent pan-genotypic and antitumor activities.
E1881New NVS-STG2 NVS-STG2(HY-157214) is a potent, allosteric small molecule agonist of STING. It binds at the transmembrane domain (TMD) interface of STING, thereby acting as a molecular glue to promote STING oligomerization and contribute to its activation. It may be used in research of STING-related autoimmune diseases.
E1835New diABZI STING agonist-1 trihydrochloride diABZI STING agonist-1 trihydrochloride is a selective stimulator of the interferon genes STING receptor, acting as an agonist with EC50 of 130 nM for human STING and 186 nM for mouse STING.
S7904 2',3'-cGAMP Sodium Salt 2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium) is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ). 2',3'-cGAMP binds to STING with Kd of 3.79 nM.
Nat Cell Biol, 2024, 10.1038/s41556-024-01473-0
Life Sci Alliance, 2024, 7(6)e202402644
S7905 3',3'-cGAMP 3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs.
E1066 SN-011 SN-011 is a STING-specific inhibitor with IC50 of 76 nM.
Mol Pharm, 2025, 10.1021/acs.molpharmaceut.4c01297
Mol Cancer, 2024, 23(1):186
E2664 Cridanimod Cridanimod, a low-Mw interferon-inducer (IFN-inducer), recognizes the intracellular signaling protein stimulator of interferon genes (STING), resulting in the STING-TBK1-IRF3 pathway activation and synthesis of type I IFNs (subtypes IFN-α and IFN-β).
E0127 C-170

C-170 is a covalent small-molecule inhibitor of STING. C-170 efficiently inhibits both hsSTING and mmSTING through the same covalent modification with C-171.

S1113 GSK690693 GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1.
Front Cell Infect Microbiol, 2025, 15:1543186
Biomol Ther (Seoul), 2025, 33(1):170-181
EMBO J, 2024, 10.1038/s44318-024-00244-9
S6575 C-176 STING inhibitor C-176 is a potent, small-molecule inhibitor of STING, a central signaling component of the intracellular DNA sensing pathway.
Nat Commun, 2025, 16(1):289
Aging Cell, 2025, e70135
Mol Pharm, 2025, 10.1021/acs.molpharmaceut.4c01297
S6494 CCCP CCCP (Carbonyl cyanide m-chlorophenyl hydrazone, Carbonyl cyanide 3-chlorophenylhydrazone), an oxidative phosphorylation inhibitor, is a protonophore mitochondrial uncoupler that increases membrane permeability to protons, leading to a disruption in the mitochondrial membrane potential. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP), the protonophore, can inhibits STING-mediated IFN-β production via disrupting mitochondrial membrane potential (MMP).
Mol Cell, 2025, 85(7):1467-1476.e6
iScience, 2025, 28(8):112972
Vet Microbiol, 2025, 303:110427
S6667 STING inhibitor C-178 C-178 is a covalent inhibitor of STING,covalently bind to Cys91.
Neurosci Lett, 2025, 847:138095
Research Square, 2023, Version 2
Cell Chem Biol, 2022, 29(10):1517-1531.e7
E0128 C-171

C-171 is a covalent small-molecule inhibitor of STING. C-171 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING.

Cell Reports, 2023, 112328
Cell Rep, 2023, 42(4):112328
E1787 SN-001 SN-001 is a potent inhibitor of STING that specifically inhibits STING activation and STING-dependent signaling. SN-011 significantly decreases inflammatory cytokine production and osteoclast formation in vivo.
E0127 C-170

C-170 is a covalent small-molecule inhibitor of STING. C-170 efficiently inhibits both hsSTING and mmSTING through the same covalent modification with C-171.

S7904 2',3'-cGAMP Sodium Salt 2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium) is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ). 2',3'-cGAMP binds to STING with Kd of 3.79 nM.
Nat Cell Biol, 2024, 10.1038/s41556-024-01473-0
Life Sci Alliance, 2024, 7(6)e202402644
S7905 3',3'-cGAMP 3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs.
S6652 H-151 H-151 is a highly potent and covalent inhibitor of STING that has noteworthy inhibitory activity both in human cells and in vivo.
Clin Transl Med, 2025, 15(3):e70235
J Neuroinflammation, 2025, 22(1):14
Biomed Pharmacother, 2025, 186:117991
E1066 SN-011 SN-011 is a STING-specific inhibitor with IC50 of 76 nM.
Mol Pharm, 2025, 10.1021/acs.molpharmaceut.4c01297
Mol Cancer, 2024, 23(1):186
S1537 Vadimezan (DMXAA) Vadimezan (DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.
Cell Chem Biol, 2025, 32(2):280-290.e14
Front Pharmacol, 2025, 16:1528459
Immun Inflamm Dis, 2025, 13(1):e70139
S8796 diABZI STING agonist (Compound 3) diABZI STING agonist (diABZI STING agonist-1, Compound 3, Tautomerism) is a potent non-nucleotide STING agonist and has tremendous potential to improve treatment of cancer in humans.Solutions are unstable and should be fresh-prepared.
Cell Discov, 2025, 11(1):23
Nat Biomed Eng, 2025, 10.1038/s41551-025-01400-0
J Exp Med, 2025, 222(5)e20241184
S0853 SR-717 lithium SR-717 lithium is a non-nucleotide STING agonist that demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 (cGAS KO) cell lines, respectively. SR-717 lithium also induces the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. SR-717 lithium exhibits antitumor activity.
Nat Commun, 2025, 16(1):3440
Pharmaceutics, 2024, 16(9)1216
Mol Neurobiol, 2022, 59(11):7006-7024
S8954 G10 (STING agonist-1) G10 (STING agonist-1) is a novel human-specific STING agonist that triggers IFN regulatory factor 3 (IRF3)/ type I interferon (IFN)-associated transcription in human fibroblasts. STING agonist-1 (G10) potently reduces growth of Chikungunya virus (CHIKV) with IC90 of 8.01 μM and blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM.
Int J Biol Sci, 2023, 19(11):3428-3440
S3804 Alpha-Mangostin Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING.
Int J Mol Sci, 2024, 25(13)7378
Front Pharmacol, 2021, 12:692806
S9681 MSA-2 MSA-2 is an orally available non-nucleotide human STING agonist with antitumor activity.
J Colloid Interface Sci, 2025, 686:1019-1032
Cell Discov, 2022, 8(1):133
E5921New ZSA-51 ZSA-51 is a potent oral agonist of STING. It exhibits potent antitumor efficacy in colon and pancreatic cancer, with superior oral PK, low toxicity, and immune microenvironment remodeling in tumors and lymph nodes.
S9618 E7766 diammonium salt E7766 diammonium salt, a macrocycle-bridged STING agonist with a Kd of 40 nM, shows potent pan-genotypic and antitumor activities.
E1881New NVS-STG2 NVS-STG2(HY-157214) is a potent, allosteric small molecule agonist of STING. It binds at the transmembrane domain (TMD) interface of STING, thereby acting as a molecular glue to promote STING oligomerization and contribute to its activation. It may be used in research of STING-related autoimmune diseases.
E1835New diABZI STING agonist-1 trihydrochloride diABZI STING agonist-1 trihydrochloride is a selective stimulator of the interferon genes STING receptor, acting as an agonist with EC50 of 130 nM for human STING and 186 nM for mouse STING.
E2664 Cridanimod Cridanimod, a low-Mw interferon-inducer (IFN-inducer), recognizes the intracellular signaling protein stimulator of interferon genes (STING), resulting in the STING-TBK1-IRF3 pathway activation and synthesis of type I IFNs (subtypes IFN-α and IFN-β).
F2884New STING (F1N19) Rabbit mAb
E5921New ZSA-51 ZSA-51 is a potent oral agonist of STING. It exhibits potent antitumor efficacy in colon and pancreatic cancer, with superior oral PK, low toxicity, and immune microenvironment remodeling in tumors and lymph nodes.
E1881New NVS-STG2 NVS-STG2(HY-157214) is a potent, allosteric small molecule agonist of STING. It binds at the transmembrane domain (TMD) interface of STING, thereby acting as a molecular glue to promote STING oligomerization and contribute to its activation. It may be used in research of STING-related autoimmune diseases.
E1835New diABZI STING agonist-1 trihydrochloride diABZI STING agonist-1 trihydrochloride is a selective stimulator of the interferon genes STING receptor, acting as an agonist with EC50 of 130 nM for human STING and 186 nM for mouse STING.

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Tags: STING antagonist | STING inhibitor | STING agonist