NADPH-oxidase

Isoform-selective Products

NADPH-oxidase Products

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  • NADPH-oxidase Inhibitors (10)
  • New NADPH-oxidase Products
Catalog No. Product Name Information Product Use Citations Product Validations
S7171 Setanaxib (GKT137831) Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. GKT137831 partly inhibits ferroptosis.
Immunity, 2024, 57(1):52-67.e10
Biomed Pharmacother, 2024, 170:116042
Nat Commun, 2023, 14(1):1235
S8639 DPI (Diphenyleneiodonium chloride) DPI (Diphenyleneiodonium chloride) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).
J Exp Clin Cancer Res, 2023, 42(1):236
J Exp Clin Cancer Res, 2023, 42(1):236
Front Immunol, 2023, 14:1089111
S2425 Apocynin (NSC 2146) Apocynin (NSC 2146, Acetovanillone, NSC 209524) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.
Antioxidants (Basel), 2023, 12(1)145
J Am Heart Assoc, 2023, 12(15):e029415
NPJ Microgravity, 2023, 9(1):7
S6656 VAS2870 VAS2870 is a pan-NADPH oxidase (NOX) inhibitor.
J Nanobiotechnology, 2023, 21(1):117
Biomaterials, 2021, 271:120720
Clin Sci (Lond), 2020, 17;134(7):853-869
S8974 GSK2795039 GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. GSK2795039 inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis.
Int J Mol Sci, 2023, 24(18)14369
Int J Mol Sci, 2023, 10.3390/ijms241814369
Sci Total Environ, 2022, 838(Pt 2):155825
S0178 GLX351322 GLX351322 is a NADPH oxidase 4 (NOX4) inhibitor. GLX351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 μM.
Biomed Pharmacother, 2023, 165:115052
Oxid Med Cell Longev, 2023, 2023:1952348
Cell Death Discov, 2022, 8(1):177
S5304 2-Acetylphenothiazine (ML171) 2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively.
PLoS One, 2023, 18(5):e0285206
Cancers (Basel), 2022, 14(11)2643
Front Oncol, 2021, 11:668617
S9617 G6PDi-1 G6PDi-1 is an effective inhibitor of glucose-6-phosphate dehydrogenase (G6PD). G6PDi-1 depletes NADPH and decreases inflammatory cytokine production.
EMBO J, 2023, e110620.
S0777 Isuzinaxib (APX-115 free base) Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.
S2348 Rotenone Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
Redox Biol, 2024, 70:103039
Sci Rep, 2023, 13(1):16893
J Ginseng Res, 2023, 47(1):144-154
S7171 Setanaxib (GKT137831) Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. GKT137831 partly inhibits ferroptosis.
Immunity, 2024, 57(1):52-67.e10
Biomed Pharmacother, 2024, 170:116042
Nat Commun, 2023, 14(1):1235
S8639 DPI (Diphenyleneiodonium chloride) DPI (Diphenyleneiodonium chloride) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).
J Exp Clin Cancer Res, 2023, 42(1):236
J Exp Clin Cancer Res, 2023, 42(1):236
Front Immunol, 2023, 14:1089111
S2425 Apocynin (NSC 2146) Apocynin (NSC 2146, Acetovanillone, NSC 209524) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.
Antioxidants (Basel), 2023, 12(1)145
J Am Heart Assoc, 2023, 12(15):e029415
NPJ Microgravity, 2023, 9(1):7
S6656 VAS2870 VAS2870 is a pan-NADPH oxidase (NOX) inhibitor.
J Nanobiotechnology, 2023, 21(1):117
Biomaterials, 2021, 271:120720
Clin Sci (Lond), 2020, 17;134(7):853-869
S8974 GSK2795039 GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. GSK2795039 inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis.
Int J Mol Sci, 2023, 24(18)14369
Int J Mol Sci, 2023, 10.3390/ijms241814369
Sci Total Environ, 2022, 838(Pt 2):155825
S0178 GLX351322 GLX351322 is a NADPH oxidase 4 (NOX4) inhibitor. GLX351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 μM.
Biomed Pharmacother, 2023, 165:115052
Oxid Med Cell Longev, 2023, 2023:1952348
Cell Death Discov, 2022, 8(1):177
S5304 2-Acetylphenothiazine (ML171) 2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively.
PLoS One, 2023, 18(5):e0285206
Cancers (Basel), 2022, 14(11)2643
Front Oncol, 2021, 11:668617
S9617 G6PDi-1 G6PDi-1 is an effective inhibitor of glucose-6-phosphate dehydrogenase (G6PD). G6PDi-1 depletes NADPH and decreases inflammatory cytokine production.
EMBO J, 2023, e110620.
S0777 Isuzinaxib (APX-115 free base) Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.
S2348 Rotenone Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
Redox Biol, 2024, 70:103039
Sci Rep, 2023, 13(1):16893
J Ginseng Res, 2023, 47(1):144-154

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Tags: NADPH-oxidase inhibitor|NADPH-oxidase agonist|NADPH-oxidase activator|NADPH-oxidase inducer|NADPH-oxidase antagonist|NADPH-oxidase signaling pathway|NADPH-oxidase assay kit