Home Immunology & Inflammation NADPH-oxidase

NADPH-oxidase

Other Immunology & Inflammation Related Inhibitors

CXCR AhR STING COX IL Receptor gp120/CD4 NOD ROS Nrf2 NOS

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S7171 Setanaxib (GKT137831) Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. This compound suppresses reactive oxygen species (ROS) production and partly inhibits ferroptosis.
Immunity, 2025, S1074-7613(25)00069-X
Int J Biol Sci, 2025, 21(5):2313-2329
Immunity, 2024, 57(1):52-67.e10
Verified customer review of Setanaxib (GKT137831)
S2518 NAD+ (β-DPN) NAD+ (β-DPN, β-NAD, β-Nicotinamide Adenine Dinucleotide,nicotinamide adenine dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
Neoplasia, January 2021, 129-139
Nat Commun, 2022, 13(1):7335
New Phytol, 2022, 233(2):890-904
S1396 Resveratrol (trans-Resveratrol) Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.
PLoS One, 2026 Mar 16, e0344872
PLoS One, 2026 Mar 16, e0344872
Theranostics, 2026, 16(9):4768-4786
Verified customer review of Resveratrol (trans-Resveratrol)
S8639 DPI (Diphenyleneiodonium chloride) Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. It also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).
Redox Biol, 2025, 80:103485
Sci Adv, 2025, 11(34):eadv6937
Exp Mol Med, 2024, 56(12):2602-2616
S2425 Apocynin Apocynin is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.
Cell Death Discov, 2025, 11(1):458
Cell Signal, 2025, 128:111630
Antioxidants (Basel), 2023, 12(1)145
Verified customer review of Apocynin
S5304 2-Acetylphenothiazine (ML171) 2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase, with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively.
American Journal of Respiratory and Critical Care Medicine, June 1, 2023, 1486-1497
Front Plant Sci, 2024, 15:1418049
American Journal of Respiratory and Critical Care Medicine, 2023, 1486-1497
S6656 VAS2870 VAS2870 is a pan-NADPH oxidase (NOX) inhibitor.
Front Oncol, 2024, 14:1438306
Frontiers in Oncology, 2024, 1438306
J Nanobiotechnology, 2023, 21(1):117
S0178 GLX351322 GLX351322 is a NADPH oxidase 4 (NOX4) inhibitor. This compound inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 μM.
Oxidative Medicine and Cellular Longevity, January 30, 2023, 1952348
Frontiers in Pharmacology, January 29, 2021, 617270
Cell Communication and Signaling, August 8, 2024, 393
S8974 GSK2795039 GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. This compound inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis.
Phytomedicine, 2024, 136:156283
Open Med (Wars), 2024, 19(1):20240898
Int J Mol Sci, 2023, 24(18)14369
S0777 Isuzinaxib (APX-115 free base) Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. This compound significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.
American Journal of Physiology-Renal Physiology, 2024, F202-F218