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NADPH-oxidase

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S7171 Setanaxib (GKT137831) Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. This compound suppresses reactive oxygen species (ROS) production and partly inhibits ferroptosis.
Immunity, 2025, S1074-7613(25)00069-X
Int J Biol Sci, 2025, 21(5):2313-2329
Immunity, 2024, 57(1):52-67.e10
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S2518 NAD+ (β-DPN) NAD+ (β-DPN, β-NAD, β-Nicotinamide Adenine Dinucleotide,nicotinamide adenine dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
Nat Commun, 2022, 13(1):7335
New Phytol, 2022, 233(2):890-904
Cell Rep, 2021, 37(8):110038
S1396 Resveratrol (trans-Resveratrol) Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.
Aging Cell, 2025, e70075
Biomed Pharmacother, 2025, 190:118393
Breast Cancer Res, 2025, 27(1):186
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S8639 DPI (Diphenyleneiodonium chloride) Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. It also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).
Redox Biol, 2025, 80:103485
Sci Adv, 2025, 11(34):eadv6937
Exp Mol Med, 2024, 56(12):2602-2616
S6656 VAS2870 VAS2870 is a pan-NADPH oxidase (NOX) inhibitor.
Front Oncol, 2024, 14:1438306
J Nanobiotechnology, 2023, 21(1):117
Biomaterials, 2021, 271:120720
S8974 GSK2795039 GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. This compound inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis.
Phytomedicine, 2024, 136:156283
Open Med (Wars), 2024, 19(1):20240898
Int J Mol Sci, 2023, 24(18)14369
S0178 GLX351322 GLX351322 is a NADPH oxidase 4 (NOX4) inhibitor. This compound inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 μM.
Cell Commun Signal, 2024, 22(1):393
Cell Commun Signal, 2024, 22(1):393.
Biomed Pharmacother, 2023, 165:115052
S5304 2-Acetylphenothiazine (ML171) 2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase, with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively.
Front Plant Sci, 2024, 15:1418049
PLoS One, 2023, 18(5):e0285206
Cancers (Basel), 2022, 14(11)2643
S0777 Isuzinaxib (APX-115 free base) Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. This compound significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.
S2425 Apocynin Apocynin is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.
Cell Death Discov, 2025, 11(1):458
Cell Signal, 2025, 128:111630
Antioxidants (Basel), 2023, 12(1)145
Verified customer review of Apocynin