NADPH-oxidase

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NADPH-oxidase Products

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  • NADPH-oxidase Inhibitors (11)
  • New NADPH-oxidase Products
Catalog No. Product Name Information Product Use Citations Product Validations
P1213New gp91ds-tat gp91ds-tat, a peptide inhibitor for NADPH oxidase assembly, is composed of gp91phox sequence linked to the human immunodeficiency virus-tat peptide. The tat sequence facilitates the entry of this peptide into cells.
S0178 GLX351322 GLX351322 is a NADPH oxidase 4 (NOX4) inhibitor. GLX351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 μM.
Front Pharmacol, 2020, 11:617270
S0777 Isuzinaxib (APX-115 free base) Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.
S2348 Rotenone (Barbasco) Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
Cell Death Dis, 2022, 13(5):436
Sci Signal, 2022, 15(721):eabi9983
Food Funct, 2022, 10.1039/d1fo03909a
S2425 Apocynin (NSC 2146) Apocynin (NSC 2146, Acetovanillone, NSC 209524) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.
J Nanobiotechnology, 2022, 20(1):78
JCI Insight, 2022, 7(3)e145475
Int J Mol Sci, 2021, 22(9)4506
S5304 2-Acetylphenothiazine (ML171) 2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively.
Front Oncol, 2021, 11:668617
ACS Nano, 2020, 24;14(3):3059-3074
S6656 VAS2870 VAS2870 is a pan-NADPH oxidase (NOX) inhibitor.
Biomaterials, 2021, 271:120720
Clin Sci (Lond), 2020, 17;134(7):853-869
J Cell Physiol, 2019, 234(4):4668-4680
S7171 Setanaxib (GKT137831) Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. GKT137831 partly inhibits ferroptosis.
Cell Chem Biol, 2022, S2451-9456(22)00127-1
Cell Death Dis, 2022, 13(4):371
Antioxidants (Basel), 2022, 11(3)513
S8639 Diphenyleneiodonium chloride (DPI) Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).
Nat Biotechnol, 2022, 10.1038/s41587-021-01169-y
Bioeng Transl Med, 2022, 7(2):e10276
J Nanobiotechnology, 2022, 20(1):65
S8974 GSK2795039 GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. GSK2795039 inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis.
Sci Total Environ, 2022, 838(Pt 2):155825
S9617 G6PDi-1 G6PDi-1 is an effective inhibitor of glucose-6-phosphate dehydrogenase (G6PD). G6PDi-1 depletes NADPH and decreases inflammatory cytokine production.
P1213New gp91ds-tat gp91ds-tat, a peptide inhibitor for NADPH oxidase assembly, is composed of gp91phox sequence linked to the human immunodeficiency virus-tat peptide. The tat sequence facilitates the entry of this peptide into cells.
S0178 GLX351322 GLX351322 is a NADPH oxidase 4 (NOX4) inhibitor. GLX351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 μM.
Front Pharmacol, 2020, 11:617270
S0777 Isuzinaxib (APX-115 free base) Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.
S2348 Rotenone (Barbasco) Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
Cell Death Dis, 2022, 13(5):436
Sci Signal, 2022, 15(721):eabi9983
Food Funct, 2022, 10.1039/d1fo03909a
S2425 Apocynin (NSC 2146) Apocynin (NSC 2146, Acetovanillone, NSC 209524) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.
J Nanobiotechnology, 2022, 20(1):78
JCI Insight, 2022, 7(3)e145475
Int J Mol Sci, 2021, 22(9)4506
S5304 2-Acetylphenothiazine (ML171) 2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively.
Front Oncol, 2021, 11:668617
ACS Nano, 2020, 24;14(3):3059-3074
S6656 VAS2870 VAS2870 is a pan-NADPH oxidase (NOX) inhibitor.
Biomaterials, 2021, 271:120720
Clin Sci (Lond), 2020, 17;134(7):853-869
J Cell Physiol, 2019, 234(4):4668-4680
S7171 Setanaxib (GKT137831) Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. GKT137831 partly inhibits ferroptosis.
Cell Chem Biol, 2022, S2451-9456(22)00127-1
Cell Death Dis, 2022, 13(4):371
Antioxidants (Basel), 2022, 11(3)513
S8639 Diphenyleneiodonium chloride (DPI) Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).
Nat Biotechnol, 2022, 10.1038/s41587-021-01169-y
Bioeng Transl Med, 2022, 7(2):e10276
J Nanobiotechnology, 2022, 20(1):65
S8974 GSK2795039 GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. GSK2795039 inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis.
Sci Total Environ, 2022, 838(Pt 2):155825
S9617 G6PDi-1 G6PDi-1 is an effective inhibitor of glucose-6-phosphate dehydrogenase (G6PD). G6PDi-1 depletes NADPH and decreases inflammatory cytokine production.
P1213New gp91ds-tat gp91ds-tat, a peptide inhibitor for NADPH oxidase assembly, is composed of gp91phox sequence linked to the human immunodeficiency virus-tat peptide. The tat sequence facilitates the entry of this peptide into cells.
Tags: NADPH-oxidase inhibitor|NADPH-oxidase agonist|NADPH-oxidase activator|NADPH-oxidase inducer|NADPH-oxidase antagonist|NADPH-oxidase signaling pathway|NADPH-oxidase assay kit