NADPH-oxidase

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NADPH-oxidase Products

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  • NADPH-oxidase Inhibitors (9)
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Catalog No. Product Name Information Product Use Citations Product Validations
S0178 GLX351322 GLX351322 is a NADPH oxidase 4 (NOX4) inhibitor. GLX351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 μM.
Front Pharmacol, 2020, 11:617270
S0777 Isuzinaxib (APX-115 free base) Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.
S2425 Apocynin (NSC 2146) Apocynin (NSC 2146, Acetovanillone, NSC 209524) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.
J Nanobiotechnology, 2022, 20(1):78
JCI Insight, 2022, 7(3)e145475
Int J Mol Sci, 2021, 22(9)4506
S5304 2-Acetylphenothiazine (ML171) 2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively.
Cancers (Basel), 2022, 14(11)2643
Front Oncol, 2021, 11:668617
ACS Nano, 2020, 24;14(3):3059-3074
S6656 VAS2870 VAS2870 is a pan-NADPH oxidase (NOX) inhibitor.
Biomaterials, 2021, 271:120720
Clin Sci (Lond), 2020, 17;134(7):853-869
J Cell Physiol, 2019, 234(4):4668-4680
S7171 Setanaxib (GKT137831) Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. GKT137831 partly inhibits ferroptosis.
Cell Chem Biol, 2022, S2451-9456(22)00127-1
Cell Death Dis, 2022, 13(4):371
Antioxidants (Basel), 2022, 11(3)513
S8639 Diphenyleneiodonium chloride (DPI) Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).
Nat Biotechnol, 2022, 10.1038/s41587-021-01169-y
Immunity, 2022, 55(7):1185-1199.e8
Bioeng Transl Med, 2022, 7(2):e10276
S8974 GSK2795039 GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. GSK2795039 inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis.
Sci Total Environ, 2022, 838(Pt 2):155825
S9617 G6PDi-1 G6PDi-1 is an effective inhibitor of glucose-6-phosphate dehydrogenase (G6PD). G6PDi-1 depletes NADPH and decreases inflammatory cytokine production.
A5256 AIF Rabbit Recombinant mAb AIF Rabbit Recombinant mAb detects endogenous level of total AIF.
A5258 NOX4 Rabbit Recombinant mAb NOX4 Rabbit Recombinant mAb detects endogenous level of total NOX4.
S0178 GLX351322 GLX351322 is a NADPH oxidase 4 (NOX4) inhibitor. GLX351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 μM.
Front Pharmacol, 2020, 11:617270
S0777 Isuzinaxib (APX-115 free base) Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.
S2425 Apocynin (NSC 2146) Apocynin (NSC 2146, Acetovanillone, NSC 209524) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.
J Nanobiotechnology, 2022, 20(1):78
JCI Insight, 2022, 7(3)e145475
Int J Mol Sci, 2021, 22(9)4506
S5304 2-Acetylphenothiazine (ML171) 2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively.
Cancers (Basel), 2022, 14(11)2643
Front Oncol, 2021, 11:668617
ACS Nano, 2020, 24;14(3):3059-3074
S6656 VAS2870 VAS2870 is a pan-NADPH oxidase (NOX) inhibitor.
Biomaterials, 2021, 271:120720
Clin Sci (Lond), 2020, 17;134(7):853-869
J Cell Physiol, 2019, 234(4):4668-4680
S7171 Setanaxib (GKT137831) Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. GKT137831 partly inhibits ferroptosis.
Cell Chem Biol, 2022, S2451-9456(22)00127-1
Cell Death Dis, 2022, 13(4):371
Antioxidants (Basel), 2022, 11(3)513
S8639 Diphenyleneiodonium chloride (DPI) Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).
Nat Biotechnol, 2022, 10.1038/s41587-021-01169-y
Immunity, 2022, 55(7):1185-1199.e8
Bioeng Transl Med, 2022, 7(2):e10276
S8974 GSK2795039 GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. GSK2795039 inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis.
Sci Total Environ, 2022, 838(Pt 2):155825
S9617 G6PDi-1 G6PDi-1 is an effective inhibitor of glucose-6-phosphate dehydrogenase (G6PD). G6PDi-1 depletes NADPH and decreases inflammatory cytokine production.
A5256 AIF Rabbit Recombinant mAb AIF Rabbit Recombinant mAb detects endogenous level of total AIF.
A5258 NOX4 Rabbit Recombinant mAb NOX4 Rabbit Recombinant mAb detects endogenous level of total NOX4.
Tags: NADPH-oxidase inhibitor|NADPH-oxidase agonist|NADPH-oxidase activator|NADPH-oxidase inducer|NADPH-oxidase antagonist|NADPH-oxidase signaling pathway|NADPH-oxidase assay kit