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β-lactamase

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Cat.No. Product Name Information Product Use Citations Product Validations
S3732 Avibactam sodium Avibactam (AVE-1330A, NXL104) is a covalent, reversible, non-β-lactam β-lactamase inhibitor with IC50 values of 8, 80, and 38 nM for TEM-1, P99, and KPC-2 β-lactamases, respectively.
Infect Drug Resist, 2025, 18:3947-3956
ACS Infect Dis, 2023, 10.1021/acsinfecdis.3c00264
Microbiol Spectr, 2022, 10(5):e0115922
E4838 Cefuroxime Cefuroxime (Kefurox) is an orally active, second-generation, broad-spectrum cephalosporin antibiotic with increased stability to β-lactamase. This compound exhibits broad-spectrum activity against Gram-positive bacteria including penicillinase-producing staphylococci and non-β-lactamase-producing gram-negative bacteria.
J Vis Exp, 2025, (223).
E4810 Piperacillin Piperacillin is a broad-spectrum β-lactam antibiotic with potent bactericidal activity against Gram-negative bacteria and selects Gram-positive strains via penicillin-binding proteins.
SSRN, 2020, 40 Pages
S4042 Nafcillin Sodium Nafcillin sodium (CL 8491) reversibly inhibits β-lactamase with Kd of 33 mM.
S2551 Sulbactam sodium Sulbactam sodium (Unasyn, CP-45899-2) is an irreversible β-lactamase inhibitor.
S5411 Sultamicillin Sultamicillin is a newly developed antibiotic in which ampicillin and the β-lactamase inhibitor sulbactam are linked as an ester.
E4985 Avibactam sodium hydrate Avibactam sodium hydrate(NXL-104 hydrate) is a covalent and reversible non-β-lactam inhibitor of β-lactamase which inhibits β-lactamase activity with IC50 values of 8 nM for TEM-1 and 5 nM for CTX-M-15, respectively.
E4820 Sulbactam pivoxil Sulbactam pivoxil (CP 47904), a proagent of sulbactam, is an inhibitor of β-lactamase. This compound provides higher absorption than its parent compound and achieves high serum levels following oral administration.
E4984 Avibactam free acid Avibactam free acid(NXL-104 free acid) is a potent, covalent, reversible, non–β-lactam Inhibitor of β-lactamase, inhibiting β-lactamase TEM-1 and CTX-M-15 with an IC50 of 8 nM and 5 nM, respectively. It is useful in research on Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium, Gram-negative infections.
E4465 Potassium clavulanate cellulose Potassium clavulanate cellulose (Potassium clavulanate:cellulose (1:1)) is a mixture of potassium clavulanate and cellulose, is a bacterial β-lactamase inhibitor. Potassium clavulanate with the combination of amoxicillin can be used for the research of different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin.