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CXCR

Isoform-selective Products

CXCR1 CXCR2 CXCR4 CXCR3

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CXCR Products

All (36)
CXCR Inhibitors (4)
CXCR Antibodies (7)
CXCR Antagonists (22)
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New CXCR Products

Catalog No.	Product Name	Information	Product Use Citations
S8030	Plerixafor (AMD3100)	Plerixafor (AMD3100, JM 3100, SID791) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor inhibits human immunodeficiency virus (HIV) replication.	Cell Mol Life Sci, 2025, 82(1):280 iScience, 2025, 28(1):111564 FEBS J, 2025, NONE
S7651	SB225002	SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.	Adv Sci (Weinh), 2025, 12(8):e2411711 Theranostics, 2025, 15(7):2852-2869 Cancer Immunol Res, 2025, 10.1158/2326-6066.CIR-24-1194
S3013	Plerixafor (AMD3100) 8HCl	Plerixafor (AMD3100, JM 3100,Plerixafor Octahydrochloride,AMD3100 octahydrochloride,SID791 octahydrochloride) 8HCl is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent.	Angiogenesis, 2025, 28(3):26 Sci Signal, 2024, 17(828):eabl3758 iScience, 2024, 27(10):110862
S2912	WZ811	WZ811 is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM.	Front Immunol, 2024, 15:1389411 Neural Regen Res, 2024, 10.4103/NRR.NRR-D-24-00081 Cells, 2024, 13(5)408
S8640	Reparixin (Repertaxin)	Reparixin (Repertaxin, DF 1681Y) is a potent and specific inhibitor of CXCR1 with IC50 of 1 nM. Reparixin (Repertaxin) inhibits PMN migration induced by CXCL8 (IC50 = 1 nM) and rodent PMN chemotaxis induced by CXCL1 and CXCL2. Repertaxin inhibits the response of human PMN to CXCL1, which interacts with CXCR2 (IC50 = 400 nM).	Immunity, 2025, S1074-7613(25)00139-6 Nat Commun, 2025, 16(1):4128 Biomed Pharmacother, 2025, 188:118203
S8813	LIT-927	LIT-927 is a novel neutraligand of CXCL12 with Ki value of 267 nM for inhibition of Texas red-labeled CXCL12 (CXCL12-TR) binding. It shows high selectivity toward CXCL12 vs other chemokines also involved in asthma.	Cell Mol Life Sci, 2025, 82(1):280 Nat Commun, 2024, 15(1):10413 Nat Commun, 2023, 14(1):5534
S8506	Navarixin (SCH-527123)	Navarixin (SCH-527123, MK-7123, PS-291822) is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively.	Biomolecules, 2025, 15(5)645 iScience, 2024, 27(8):110562 Mol Ther Oncol, 2024, 32(1):200777
S4785	Nicotinamide N-oxide	Nicotinamide N-oxide (Nicotinamide 1-oxide, 1-oxynicotinamide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. Nicotinamide N-oxide is novel, potent, and selective antagonists of the CXCR2 receptor.	Front Immunol, 2025, 16:1552993 Inflammation, 2024, Cell Rep, 2023, 42(6):112566
S8869	UNBS5162	UNBS5162 is a pan-antagonist of CXCL chemokine expression with in vitro cytotoxic activity (IC50 range of 0.5-5 µM) against a range of human cancer cell lines including glioblastoma (Hs683 and U373MG), colorectal (HCT-15 and LoVo), non-small-cell lung (A549) and breast (MCF-7).	Cell Discov, 2023, 9(1):104 Cell Discov, 2023, 9(1):104
S8505	LY2510924	LY2510924 is a potent and selective CXCR4 antagonist that specifically blocks SDF-1 binding to CXCR4 with IC50 value of 0.079 nmol/L and inhibits SDF-1-induced GTP binding with Kb value of 0.38 nmol/L.	Front Physiol, 2024, 15:1349119 Nat Commun, 2023, 14(1):2207
S6645	AZD5069	AZD5069 is a novel antagonist of CXCR2, which is shown to inhibit binding of CXCL8 to CXCR2 with a pIC50 value of 8.8 and inhibit CXCL8 binding to CXCR1 with pIC50 values of 6.5.	Biomed Pharmacother, 2025, 188:118203 Biomolecules, 2025, 15(5)645 Cell Rep, 2022, 38(10):110490
S2879	AMD3465 hexahydrobromide	AMD3465 is a monomacrocyclic CXCR4 antagonist.	Front Oncol, 2021, 11:708915
S8682	AMG 487	AMG 487 is an orally active and selective CXC chemokine receptor 3 (CXCR3) antagonist that inhibits the binding of IP-10 (CXCL10) and ITAC (CXCL11) to CXCR3 with IC50 of 8.0 nM and 8.2 nM, respectively.	Nat Commun, 2025, 16(1):3905 Sci Rep, 2025, 15(1):20778 Front Immunol, 2022, 13:923492
S8947	SX-682	SX-682 is an orally bioavailable small-molecule allosteric inhibitor of CXCR1 and CXCR2 that blocks tumor MDSC recruitment and enhances T cell activation and antitumor immunity.	Biomolecules, 2025, 15(5)645 Cell Metab, 2024, 36(5):984-999.e8 Nat Commun, 2023, 14(1):4677
S6620	Danirixin (GSK1325756)	Danirixin (GSK1325756) is a small molecule, non-peptide, high affinity (IC50 for CXCL8 (IL-8) binding = 12.5 nM), selective, and reversible CXCR2 antagonist.	Redox Biol, 2024, 76:103323 Theranostics, 2019, 9(18):5332-5346
S6617	MSX-122	MSX-122 (Q-122) is a novel small molecule and partial CXCR4 antagonist (IC50~10 nM).	Cell Mol Gastroenterol Hepatol, 2023, 10.1016/j.jcmgh.2023.10.007
F1523^New	Anti-CXCL12/SDF-1 Mouse Antibody [N2D21]	SDF1,SDF-1,SDF1/CXCL12,SDF-1/CXCL12
E1318	Mavorixafor	Mavorixafor (AMD-070) is a potent, selective CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.
S0292	MSX-127	MSX-127 (NSC-23026) is a C-X-C chemokine receptor type 4 (CXCR4) receptor antagonist.
S0293	MSX-130	MSX-130 is an antagonist of C-X-C chemokine receptor type 4 (CXCR4).
E7614^New	NBI-74330	NBI-74330 is a potent antagonist for CXCR3, and exhibits potent inhibition of (125I)CXCL10 and (125I)CXCL11 specific binding with Ki of 1.5 and 3.2 nM, respectively.
A2868	Anti-CXCL10 / IP-10 (NI-0801)	Anti-CXCL10 / IP-10 (NI-0801) is a fully human monoclonal antibody against chemokine (C-X-C motif) ligand 10 (CXCL10). It has the potential to treat primary biliary cholangitis. MW: 146.08.
E4650^New	Ladarixin	Ladarixin(DF 2156A free base) is a small molecule, orally available, allosteric and non-competitive antagonist of dual CXCR1 and CXCR2. It is able to reduce the acute and chronic neutrophilic influx, and can be used in research of Asthma, Idiopathic Pulmonary Fibrosis, Influenza-A infection and COPD, cutaneous and uveal melanoma conditions.
A2670	Anti-CXCL8 / IL-8 (HuMax-IL8)	Anti-CXCL8 / IL-8 (HuMax-IL8) is a monoclonal antibody targeting CXCL8. It has strong antitumor effect. MW :144.94 KD.
A2706	Anti-CXCR3 / GPR9 / CD183	Anti-CXCR3 / GPR9 / CD183 is a monoclonal antibody binds to Chemokine (C-X-C motif) receptor 3 (CXCR3, also known as G protein-coupled receptor 9 (GPR9)) . It has the potentially to be used in the treatment of diabetes mellitus type I (T1D). MW: 146.38 KD.
A2523	Ulocuplumab (Anti-CXCR4 / CD184)	Ulocuplumab (Anti-CXCR4 / CD184) is a fully human IgG4 antibody, targeting CXCR4. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models. MW: 144.84 KD.
A2524	Anti-CXCL8 / IL-8	Anti-CXCL8 / IL-8 (ABX-IL8) is a antibody targeting CXCL8. MW: 145.5 KD.
A2525	Eldelumab (Anti-CXCL10 / IP-10)	Eldelumab (Anti-CXCL10 / IP-10) is a humanised monoclonal antibody (IgG1 type) targeting CXCL10. Eldelumab selectively binds to CXCL10 and blocks CXCL10-induced calcium flux and cell migration. Eldelumab can be used in studies of autoimmune and auto-inflammatory diseases such as rheumatoid arthritis, ulcerative colitis and crohn's disease. MW: 145.5 KD.
S3951	Tannic acid	Tannic acid (Gallotannic acid), a polyphenolic compound, is a CXCL12/CXCR4 inhibitor with antiangiogenic, anti-inflammatory and antitumor activity.
S9665	Motixafortide (BL-8040)	Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) is an antagonist of CXCR4 with IC50 of ～1 nM. BL-8040 induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.
A2721	Anti-CXCL4 / PF4	Anti-CXCL4 / PF4 is a monoclonal antibody against anti-CXC chemokine ligand 4 (CXCL4, also called PF4). MW: 144.86 KD.
S0438	TAK-779	TAK-779(Takeda 779), a nonpeptide compound, is a potent antagonist of CCR5 and CXCR3, with a Ki of 1.1 nM for CCR5. It also exhibits highly potent and selective inhibition of R5 HIV-1 replication with EC50 and EC90 of 1.2 and 5.7 nM, respectively. It also suppresses the development of the cytokine storm in the murine model of the SARS-CoV-2-related acute respiratory distress syndrome.
S9516	SB 265610	SB265610, a competitive antagonist at the human CXCR2 receptor, can displace [125I]-IL-8 and [125I]-GROα with pIC50 values of 8.41 and 8.47 respectively, preventing receptor activation by binding to a region distinct from the agonist binding site.	Biomed Pharmacother, 2025, 188:118203
S9725	Balixafortide (POL6326)	Balixafortide (POL6326) is an orally bioavailable peptidic CXC chemokine receptor 4 (CXCR4) antagonist.
S8309	ATI-2341	ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization.
E5984^New	ML339	ML339 is a potent and selective antagonist of CXCR6. ML339 antagonizes CXCL16-induced β-arrestin recruitment and cAMP signaling through the human CXCR6 receptor with IC50 values of 0.3 and 1.4 μM, respectively. ML339 shows no inhibitory activity against CXCR5, CXCR4, and CCR6. ML339 can be used as a potential agent for prostate cancer research.
S8640	Reparixin (Repertaxin)	Reparixin (Repertaxin, DF 1681Y) is a potent and specific inhibitor of CXCR1 with IC50 of 1 nM. Reparixin (Repertaxin) inhibits PMN migration induced by CXCL8 (IC50 = 1 nM) and rodent PMN chemotaxis induced by CXCL1 and CXCL2. Repertaxin inhibits the response of human PMN to CXCL1, which interacts with CXCR2 (IC50 = 400 nM).	Immunity, 2025, S1074-7613(25)00139-6 Nat Commun, 2025, 16(1):4128 Biomed Pharmacother, 2025, 188:118203
S8947	SX-682	SX-682 is an orally bioavailable small-molecule allosteric inhibitor of CXCR1 and CXCR2 that blocks tumor MDSC recruitment and enhances T cell activation and antitumor immunity.	Biomolecules, 2025, 15(5)645 Cell Metab, 2024, 36(5):984-999.e8 Nat Commun, 2023, 14(1):4677
E7614^New	NBI-74330	NBI-74330 is a potent antagonist for CXCR3, and exhibits potent inhibition of (125I)CXCL10 and (125I)CXCL11 specific binding with Ki of 1.5 and 3.2 nM, respectively.
S3951	Tannic acid	Tannic acid (Gallotannic acid), a polyphenolic compound, is a CXCL12/CXCR4 inhibitor with antiangiogenic, anti-inflammatory and antitumor activity.
A2868	Anti-CXCL10 / IP-10 (NI-0801)	Anti-CXCL10 / IP-10 (NI-0801) is a fully human monoclonal antibody against chemokine (C-X-C motif) ligand 10 (CXCL10). It has the potential to treat primary biliary cholangitis. MW: 146.08.
A2670	Anti-CXCL8 / IL-8 (HuMax-IL8)	Anti-CXCL8 / IL-8 (HuMax-IL8) is a monoclonal antibody targeting CXCL8. It has strong antitumor effect. MW :144.94 KD.
A2706	Anti-CXCR3 / GPR9 / CD183	Anti-CXCR3 / GPR9 / CD183 is a monoclonal antibody binds to Chemokine (C-X-C motif) receptor 3 (CXCR3, also known as G protein-coupled receptor 9 (GPR9)) . It has the potentially to be used in the treatment of diabetes mellitus type I (T1D). MW: 146.38 KD.
A2523	Ulocuplumab (Anti-CXCR4 / CD184)	Ulocuplumab (Anti-CXCR4 / CD184) is a fully human IgG4 antibody, targeting CXCR4. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models. MW: 144.84 KD.
A2524	Anti-CXCL8 / IL-8	Anti-CXCL8 / IL-8 (ABX-IL8) is a antibody targeting CXCL8. MW: 145.5 KD.
A2525	Eldelumab (Anti-CXCL10 / IP-10)	Eldelumab (Anti-CXCL10 / IP-10) is a humanised monoclonal antibody (IgG1 type) targeting CXCL10. Eldelumab selectively binds to CXCL10 and blocks CXCL10-induced calcium flux and cell migration. Eldelumab can be used in studies of autoimmune and auto-inflammatory diseases such as rheumatoid arthritis, ulcerative colitis and crohn's disease. MW: 145.5 KD.
A2721	Anti-CXCL4 / PF4	Anti-CXCL4 / PF4 is a monoclonal antibody against anti-CXC chemokine ligand 4 (CXCL4, also called PF4). MW: 144.86 KD.
S8030	Plerixafor (AMD3100)	Plerixafor (AMD3100, JM 3100, SID791) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor inhibits human immunodeficiency virus (HIV) replication.	Cell Mol Life Sci, 2025, 82(1):280 iScience, 2025, 28(1):111564 FEBS J, 2025, NONE
S7651	SB225002	SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.	Adv Sci (Weinh), 2025, 12(8):e2411711 Theranostics, 2025, 15(7):2852-2869 Cancer Immunol Res, 2025, 10.1158/2326-6066.CIR-24-1194
S3013	Plerixafor (AMD3100) 8HCl	Plerixafor (AMD3100, JM 3100,Plerixafor Octahydrochloride,AMD3100 octahydrochloride,SID791 octahydrochloride) 8HCl is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent.	Angiogenesis, 2025, 28(3):26 Sci Signal, 2024, 17(828):eabl3758 iScience, 2024, 27(10):110862
S2912	WZ811	WZ811 is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM.	Front Immunol, 2024, 15:1389411 Neural Regen Res, 2024, 10.4103/NRR.NRR-D-24-00081 Cells, 2024, 13(5)408
S8813	LIT-927	LIT-927 is a novel neutraligand of CXCL12 with Ki value of 267 nM for inhibition of Texas red-labeled CXCL12 (CXCL12-TR) binding. It shows high selectivity toward CXCL12 vs other chemokines also involved in asthma.	Cell Mol Life Sci, 2025, 82(1):280 Nat Commun, 2024, 15(1):10413 Nat Commun, 2023, 14(1):5534
S8506	Navarixin (SCH-527123)	Navarixin (SCH-527123, MK-7123, PS-291822) is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively.	Biomolecules, 2025, 15(5)645 iScience, 2024, 27(8):110562 Mol Ther Oncol, 2024, 32(1):200777
S4785	Nicotinamide N-oxide	Nicotinamide N-oxide (Nicotinamide 1-oxide, 1-oxynicotinamide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. Nicotinamide N-oxide is novel, potent, and selective antagonists of the CXCR2 receptor.	Front Immunol, 2025, 16:1552993 Inflammation, 2024, Cell Rep, 2023, 42(6):112566
S8505	LY2510924	LY2510924 is a potent and selective CXCR4 antagonist that specifically blocks SDF-1 binding to CXCR4 with IC50 value of 0.079 nmol/L and inhibits SDF-1-induced GTP binding with Kb value of 0.38 nmol/L.	Front Physiol, 2024, 15:1349119 Nat Commun, 2023, 14(1):2207
S6645	AZD5069	AZD5069 is a novel antagonist of CXCR2, which is shown to inhibit binding of CXCL8 to CXCR2 with a pIC50 value of 8.8 and inhibit CXCL8 binding to CXCR1 with pIC50 values of 6.5.	Biomed Pharmacother, 2025, 188:118203 Biomolecules, 2025, 15(5)645 Cell Rep, 2022, 38(10):110490
S2879	AMD3465 hexahydrobromide	AMD3465 is a monomacrocyclic CXCR4 antagonist.	Front Oncol, 2021, 11:708915
S8682	AMG 487	AMG 487 is an orally active and selective CXC chemokine receptor 3 (CXCR3) antagonist that inhibits the binding of IP-10 (CXCL10) and ITAC (CXCL11) to CXCR3 with IC50 of 8.0 nM and 8.2 nM, respectively.	Nat Commun, 2025, 16(1):3905 Sci Rep, 2025, 15(1):20778 Front Immunol, 2022, 13:923492
S6620	Danirixin (GSK1325756)	Danirixin (GSK1325756) is a small molecule, non-peptide, high affinity (IC50 for CXCL8 (IL-8) binding = 12.5 nM), selective, and reversible CXCR2 antagonist.	Redox Biol, 2024, 76:103323 Theranostics, 2019, 9(18):5332-5346
S6617	MSX-122	MSX-122 (Q-122) is a novel small molecule and partial CXCR4 antagonist (IC50~10 nM).	Cell Mol Gastroenterol Hepatol, 2023, 10.1016/j.jcmgh.2023.10.007
E1318	Mavorixafor	Mavorixafor (AMD-070) is a potent, selective CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.
S0292	MSX-127	MSX-127 (NSC-23026) is a C-X-C chemokine receptor type 4 (CXCR4) receptor antagonist.
S0293	MSX-130	MSX-130 is an antagonist of C-X-C chemokine receptor type 4 (CXCR4).
E4650^New	Ladarixin	Ladarixin(DF 2156A free base) is a small molecule, orally available, allosteric and non-competitive antagonist of dual CXCR1 and CXCR2. It is able to reduce the acute and chronic neutrophilic influx, and can be used in research of Asthma, Idiopathic Pulmonary Fibrosis, Influenza-A infection and COPD, cutaneous and uveal melanoma conditions.
S9665	Motixafortide (BL-8040)	Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) is an antagonist of CXCR4 with IC50 of ～1 nM. BL-8040 induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.
S0438	TAK-779	TAK-779(Takeda 779), a nonpeptide compound, is a potent antagonist of CCR5 and CXCR3, with a Ki of 1.1 nM for CCR5. It also exhibits highly potent and selective inhibition of R5 HIV-1 replication with EC50 and EC90 of 1.2 and 5.7 nM, respectively. It also suppresses the development of the cytokine storm in the murine model of the SARS-CoV-2-related acute respiratory distress syndrome.
S9516	SB 265610	SB265610, a competitive antagonist at the human CXCR2 receptor, can displace [125I]-IL-8 and [125I]-GROα with pIC50 values of 8.41 and 8.47 respectively, preventing receptor activation by binding to a region distinct from the agonist binding site.	Biomed Pharmacother, 2025, 188:118203
S9725	Balixafortide (POL6326)	Balixafortide (POL6326) is an orally bioavailable peptidic CXC chemokine receptor 4 (CXCR4) antagonist.
E5984^New	ML339	ML339 is a potent and selective antagonist of CXCR6. ML339 antagonizes CXCL16-induced β-arrestin recruitment and cAMP signaling through the human CXCR6 receptor with IC50 values of 0.3 and 1.4 μM, respectively. ML339 shows no inhibitory activity against CXCR5, CXCR4, and CCR6. ML339 can be used as a potential agent for prostate cancer research.
S8309	ATI-2341	ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization.
S8869	UNBS5162	UNBS5162 is a pan-antagonist of CXCL chemokine expression with in vitro cytotoxic activity (IC50 range of 0.5-5 µM) against a range of human cancer cell lines including glioblastoma (Hs683 and U373MG), colorectal (HCT-15 and LoVo), non-small-cell lung (A549) and breast (MCF-7).	Cell Discov, 2023, 9(1):104 Cell Discov, 2023, 9(1):104
F1523^New	Anti-CXCL12/SDF-1 Mouse Antibody [N2D21]	SDF1,SDF-1,SDF1/CXCL12,SDF-1/CXCL12
E7614^New	NBI-74330	NBI-74330 is a potent antagonist for CXCR3, and exhibits potent inhibition of (125I)CXCL10 and (125I)CXCL11 specific binding with Ki of 1.5 and 3.2 nM, respectively.
E4650^New	Ladarixin	Ladarixin(DF 2156A free base) is a small molecule, orally available, allosteric and non-competitive antagonist of dual CXCR1 and CXCR2. It is able to reduce the acute and chronic neutrophilic influx, and can be used in research of Asthma, Idiopathic Pulmonary Fibrosis, Influenza-A infection and COPD, cutaneous and uveal melanoma conditions.
E5984^New	ML339	ML339 is a potent and selective antagonist of CXCR6. ML339 antagonizes CXCL16-induced β-arrestin recruitment and cAMP signaling through the human CXCR6 receptor with IC50 values of 0.3 and 1.4 μM, respectively. ML339 shows no inhibitory activity against CXCR5, CXCR4, and CCR6. ML339 can be used as a potential agent for prostate cancer research.

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