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Other PI3K/Akt/mTOR Related Inhibitors

PI3K mTOR Akt GSK-3 DNA-PK ATM/ATR PDK AMPK PTEN MELK
Cat.No. Product Name Information Product Use Citations Product Validations
S9803 Elamipretide (SS-31, MTP-131) Elamipretide (MTP-131, SS-31) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.
Ecotoxicol Environ Saf, 2025, 290:117622
Ecotoxicol Environ Saf, 2025, 296:118202
Neurotherapeutics, 2025, S1878-7479(25)00250-8
S8978 MitoQ (Mitoquinone) Mesylate MitoQ (Mitoquinone) mesylate is a TPP-based, mitochondria-targeted antioxidant that blocks H2O2-induced intracellular ROS responses and protects against oxidative damage. This product is a waxy solid.
Cancer Cell, 2025, 43(1):69-85.e11
Sci Adv, 2025, 11(35):eadw9952
bioRxiv, 2025, 2025.02.19.639120
S2391 Quercetin (Sophoretin) Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.
Alzheimers Res Ther, 2025, 17(1):176
Cell Mol Life Sci, 2025, 82(1):164
Virol Sin, 2025, S1995-820X(25)00102-6
Verified customer review of Quercetin (Sophoretin)
S3114 L-Ascorbic Acid (Vitamin C) Vitamin C (L-Ascorbic acid) is a water-soluble vitamin indicated for the prevention and treatment of scurvy.
Biomaterials, 2025, 314:122873
Nat Commun, 2024, 15(1):2384
Research (Wash D C), 2024, 7:0457
S2250 EGCG ((-)-Epigallocatechin Gallate) EGCG ((-)-Epigallocatechin Gallate) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
Clin Mol Hepatol, 2025, 10.3350/cmh.2024.0694
Cell Rep, 2025, 44(6):115799
Front Pharmacol, 2024, 15:1403424
Verified customer review of EGCG ((-)-Epigallocatechin Gallate)
S4606 GSH (L-Glutathione reduced) GSH (Glutathione) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.
Redox Biol, 2025, 83:103615
Cell Death Dis, 2025, 16(1):396
Elife, 2025, 13RP100406
S1326 Edaravone Edaravone (MCI-186) is a novel potent free radical scavenger that has been clinically used to reduce the neuronal damage following ischemic stroke.
EMBO Mol Med, 2025, 10.1038/s44321-025-00204-8
J Immunother Cancer, 2024, 12(11)e009805
Sci Adv, 2023, 9(6):eade8829
S2363 Tangeretin Tangeretin (Tangeritin), a natural polymethoxylated flavone concentrated in the peel of citrus fruits, an inhibitor of Notch1, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities.
Heliyon, 2024, 10(21):e39797
Transl Oncol, 2023, 35:101712
Evid Based Complement Alternat Med, 2022, 2022:6422500
S4722 (+)-Catechin (+)-Catechin (Cianidanol, Catechinic acid, Catechuic acid) is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.,
Pharmaceutics, 2025, 17(8)985
Sci Rep, 2023, 13(1):18492.
Sci Rep, 2023, 13(1):18492
S9205 Hydroxygenkwanin Hydroxygenkwanin (7-O-Methylluteolin), a natural flavonoid compound, has anti-oxidant ability and can act as tissue factor (TF) inhibitor to prevent thrombosis. This compound, a natural flavonoid compound, has anti-oxidant ability and can act as tissue factor (TF) inhibitor to prevent thrombosis.
Antioxidants (Basel), 2022, 2197
Antioxidants (Basel), 2022, 11(11)2197
Int J Mol Sci, 2022, 23(21)12763