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Other PI3K/Akt/mTOR Related Inhibitors

PI3K mTOR Akt GSK-3 DNA-PK ATM/ATR PDK AMPK PTEN MELK
Cat.No. Product Name Information Product Use Citations Product Validations
S9803 Elamipretide (SS-31, MTP-131) Elamipretide (MTP-131, SS-31) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.
Ecotoxicol Environ Saf, 2025, 290:117622
Ecotoxicol Environ Saf, 2025, 296:118202
Neurotherapeutics, 2025, S1878-7479(25)00250-8
S8978 MitoQ (Mitoquinone) Mesylate MitoQ (Mitoquinone) mesylate is a TPP-based, mitochondria-targeted antioxidant that blocks H2O2-induced intracellular ROS responses and protects against oxidative damage. This product is a waxy solid.
Cancer Cell, 2025, 43(1):69-85.e11
Sci Adv, 2025, 11(35):eadw9952
bioRxiv, 2025, 2025.02.19.639120
S2391 Quercetin (Sophoretin) Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.
Alzheimers Res Ther, 2025, 17(1):176
Cell Mol Life Sci, 2025, 82(1):164
Virol Sin, 2025, S1995-820X(25)00102-6
Verified customer review of Quercetin (Sophoretin)
S3114 L-Ascorbic Acid (Vitamin C) Vitamin C (L-Ascorbic acid) is a water-soluble vitamin indicated for the prevention and treatment of scurvy.
bioRxiv, July 14, 2025, nan
Cellular and Molecular Life Sciences, February 16, 2024, 92
Biomaterials, 2025, 314:122873
S2250 EGCG ((-)-Epigallocatechin Gallate) EGCG ((-)-Epigallocatechin Gallate) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
Clin Mol Hepatol, 2025, 10.3350/cmh.2024.0694
Cell Rep, 2025, 44(6):115799
Front Pharmacol, 2024, 15:1403424
Verified customer review of EGCG ((-)-Epigallocatechin Gallate)
S4606 GSH (L-Glutathione reduced) GSH (Glutathione) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.
Redox Biol, 2025, 83:103615
Cell Death Dis, 2025, 16(1):396
Elife, 2025, 13RP100406
S1326 Edaravone Edaravone (MCI-186) is a novel potent free radical scavenger that has been clinically used to reduce the neuronal damage following ischemic stroke.
EMBO Mol Med, 2025, 10.1038/s44321-025-00204-8
J Immunother Cancer, 2024, 12(11)e009805
Sci Adv, 2023, 9(6):eade8829
S2363 Tangeretin Tangeretin (Tangeritin), a natural polymethoxylated flavone concentrated in the peel of citrus fruits, an inhibitor of Notch1, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities.
Heliyon, 2024, 10(21):e39797
Transl Oncol, 2023, 35:101712
Evid Based Complement Alternat Med, 2022, 2022:6422500
S2358 Silymarin Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.
American Journal of Translational Research, February 15, 2016, 1073-1081
Research gate, 2023,
Chemico-Biological Interactions, 2022, 110168
Verified customer review of Silymarin
S4206 Cysteamine HCl Cysteamine HCl(Mercaptamine) is an autophagy-stimulatory proteostasis regulator. This compound can be used for the treatment of nephropathic cystinosis and an antioxidant.It can be used to induce animal models of Duodenal Ulcer.
Nat Commun, 2023, 14(1):7598
Pharmaceutics, 2022, 491
Pharmaceutics, 2022, 14(3)491