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Prostaglandin Receptor

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S7211 PF-04418948 PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1.
Cancer Res Commun, 2025, 5(1):13-23
Cancer Research Communications, 2025, 13-23
International Journal of Molecular Sciences, 2023, 10881
S6649 E7046 (ER-886406) E7046 (ER-886406, Palupiprant, AN0025) is a selective inhibitor of the prostaglandin E2 (PGE2) receptor EP4 with IC50 of 13.5 nM and Ki of 23.14 nM.
Cells, 2025, 1992
Cancers, 2023, 4197
Cell Mol Life Sci, 2022, 79(6):303
S1407 Bimatoprost Bimatoprost(AGN 192024) is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
PLoS Pathog, 2020, 16;16(3):e1008341
Investigative Ophthalmology & Visual Science, 2018, 5912-5923
Invest Ophthalmol Vis Sci, 2018, 59(15):5912-5923
S3726 Selexipag Selexipag (NS-304, ACT-293987) is an orally active, first-in-class, selective prostacyclin IP receptor agonist with Ki value of 260 nM for human IP, whereas Ki values > 10,000 nM are measured at the other human G-protein-coupled prostanoid receptors (EP1-4, DP, FP and TP).
J Immunother Cancer, 2024, 12(11)e009805
Biol Pharm Bull, 2022, 10.1248/bpb.b21-01057
Front Med (Lausanne), 2021, 8:742436
E0809 Timapiprant Sodium Timapiprant sodium (OC000459 sodium), a potent, selective, and orally active D prostanoid receptor 2 (DP2, also known as CRTH2) antagonist, potently displaces [3H]PGD2 from human recombinant DP2, rat recombinant DP2, and human native DP2 with Ki values of 13, 3 and 4 nM, respectively.
Science Advances, 2025, eadv1492
Sci Adv, 2025, 11(29):eadv1492
Drug Development Research, 2024, e22232
S6793 TG4-155 TG4-155 is a potent and selective Prostaglandin Receptor EP2(PTGER2) antagonist with Ki value of 9.9 nM.
Transl Neurodegener, 2025, 14(1):43
Elife, 2023, 12e81438
bioRxiv, 2021, 10.1101/2021.08.27.457936
S6694 Grapiprant (CJ-023,423) Grapiprant (CJ-023,423, AT-001, AAT-007, RQ-00000007, CJ-23423) is a novel selective EP4 Prostaglandin Receptor inhibitor with Ki of 20 nM and 13 nM for rat EP4 receptor and human EP4 receptor, respectively.
Bone Research, 2022, 27
Bone Res, 2022, 10(1):27
S3346 1-Methylnicotinamide chloride

1-Methylnicotinamide (1-MNA, 3-Carbamoyl-1-methylpyridin-1-ium, Trigonellamide) chloride is an active endogenous metabolite of nicotinamide that exhibits anti-inflammatory and anti-thrombotic activities. 1-Methylnicotinamide enhances tumor vasculature formation and markedly increases prostacyclin (PGI2) generation.
Oncol Rep, 2021, 45(6)110
Oncology Reports, 2021, 110
S2072 Seratrodast(AA-2414) Seratrodast (AA-2414, ABT-001) is a potent and selective thromboxane A2 receptor (TP) antagonist which is used primarily in the treatment of asthma and used as anti-inflammatory agent.
Molecules, 2025, 3772
Molecules, 2025, 30(18)3772
S4152 Ethamsylate Ethamsylate (Etamsylate) is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.
J Immunother Cancer, 2024, 12(11)e009805