Prostaglandin Receptor
Inhibitory Selectivity
Prostaglandin Receptor Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S6649New |
E7046（ER-886406）E7046 is a selective inhibitor of the prostaglandin E2 (PGE2) receptor EP4 with IC50 of 13.5 nM and Ki of 23.14 nM. |
||
| S5753 |
Setipiprant(ACT-129968)Setipiprant(ACT-129968, KYTH-105) is a selective, orally available antagonist of the prostaglandin D2 receptor 2 (DP2) that that has been shown to have greater specificity for DP2 (CRTH2) than for DP1. |
||
| S6694New |
Grapiprant (CJ-023423)Grapiprant is the first EP4 receptor-specific antagonist approved by FDA for control of pain and inflammation in dogs with osteoarthritis. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor in a concentration-dependent manner with an IC50 value of 35 nM and with a Ki value of 24 nM. |
||
| S7211 |
PF-04418948PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1. |
||
| S1407 |
BimatoprostBimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. |
||
| S1508 |
AlprostadilAlprostadil is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist. |
||
| S3003 |
Prostaglandin E2 (PGE2)Prostaglandin E2 palys important effects in labour (softens cervix and causes uterine contraction) and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts. |
||
| S4851 |
TafluprostTafluprost is a novel prostaglandin analog with a high affinity for the fluoroprostaglandin (FP) receptor PGF2α. A prostanoid selective FP receptor agonist. |
||
| S9327 |
CarboprostCarboprost is a synthetic prostaglandin analogue of PGF2α with oxytocic properties. |
||
| S5819 |
MRE-269(ACT-333679)MRE-269(ACT-333679) is a prostaglandin I2 (IP) receptor agonist with a binding affinity for the human IP receptor that is 130-fold greater than that for other human prostanoid receptor. |
||
| S3738 |
TravoprostTravoprost is a PGF2a analog that was launched as an ophthalmic solution administered topically for the treatment of elevated intraocular hypertension as a result of open-angle glaucoma, a common optic neuropathy, and a leading cause of blindness. It can act as an agonist of prostaglandin F receptor. |
||
| S5056 |
Dinoprost tromethamineDinoprost Tromethamine is a synthetic analogue of the naturally occurring prostaglandin F2 alpha, which stimulates myometrial activity, relaxes the cervix, inhibits corpus luteal steroidogenesis, and induces luteolysis by direct action on the corpus luteum. |
||
| S4152 |
EthamsylateEthamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S6649New |
E7046（ER-886406）E7046 is a selective inhibitor of the prostaglandin E2 (PGE2) receptor EP4 with IC50 of 13.5 nM and Ki of 23.14 nM. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S5753 |
Setipiprant(ACT-129968)Setipiprant(ACT-129968, KYTH-105) is a selective, orally available antagonist of the prostaglandin D2 receptor 2 (DP2) that that has been shown to have greater specificity for DP2 (CRTH2) than for DP1. |
||
| S6694New |
Grapiprant (CJ-023423)Grapiprant is the first EP4 receptor-specific antagonist approved by FDA for control of pain and inflammation in dogs with osteoarthritis. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor in a concentration-dependent manner with an IC50 value of 35 nM and with a Ki value of 24 nM. |
||
| S7211 |
PF-04418948PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1407 |
BimatoprostBimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. |
||
| S1508 |
AlprostadilAlprostadil is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist. |
||
| S3003 |
Prostaglandin E2 (PGE2)Prostaglandin E2 palys important effects in labour (softens cervix and causes uterine contraction) and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts. |
||
| S4851 |
TafluprostTafluprost is a novel prostaglandin analog with a high affinity for the fluoroprostaglandin (FP) receptor PGF2α. A prostanoid selective FP receptor agonist. |
||
| S9327 |
CarboprostCarboprost is a synthetic prostaglandin analogue of PGF2α with oxytocic properties. |
||
| S5819 |
MRE-269(ACT-333679)MRE-269(ACT-333679) is a prostaglandin I2 (IP) receptor agonist with a binding affinity for the human IP receptor that is 130-fold greater than that for other human prostanoid receptor. |
||
| S3738 |
TravoprostTravoprost is a PGF2a analog that was launched as an ophthalmic solution administered topically for the treatment of elevated intraocular hypertension as a result of open-angle glaucoma, a common optic neuropathy, and a leading cause of blindness. It can act as an agonist of prostaglandin F receptor. |
||
| S5056 |
Dinoprost tromethamineDinoprost Tromethamine is a synthetic analogue of the naturally occurring prostaglandin F2 alpha, which stimulates myometrial activity, relaxes the cervix, inhibits corpus luteal steroidogenesis, and induces luteolysis by direct action on the corpus luteum. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S4152 |
EthamsylateEthamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion. |
