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Nrf2 activators/inhibitors

Other Immunology & Inflammation Related Inhibitors

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Cat.No. Product Name Information Product Use Citations Product Validations
S7672 Omaveloxolone (RTA-408) Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
J Clin Invest, 2025, 135(14)e176655
Redox Biol, 2025, 87:103885
Front Pharmacol, 2025, 16:1539032
S8078 Bardoxolone Methyl (RTA 402) Bardoxolone Methyl (RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me) is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. Bardoxolone Methyl abrogates ferroptosis. Bardoxolone methyl induces apoptosis and autophagy in cancer cells.
J Clin Invest, 2025, 135(14)e176655
Redox Biol, 2025, 87:103885
Research (Wash D C), 2025, 8:0980
Verified customer review of Bardoxolone Methyl (RTA 402)
S8790 ML385 ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. This compound regulates the activity of several ferroptosis and lipid peroxidation-related proteins.
Signal Transduct Target Ther, 2025, 10(1):323
Redox Biol, 2025, 84:103657
EMBO Mol Med, 2025, 10.1038/s44321-025-00293-5
S5771 Sulforaphane Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. This compound is also an inhibitor of histone deacetylase (HDAC) and NF-κB. It increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). It induces cell cycle arrest and apoptosis.
J Clin Invest, 2025, 135(14)e176655
Sci Rep, 2025, 15(1):21271
BMC Cancer, 2025, 25(1):1050
S7956 Brusatol Brusatol (NSC 172924), isolated from the fruit of B. javanica, is a NRF2 inhibitor.
EMBO Mol Med, 2025, 17(7):1794-1824
J Zhejiang Univ Sci B, 2025, 26(9):881-896
Neurochem Int, 2025, 188:106004
S4990 TBHQ Tert-butylhydroquinone (TBHQ) is an antioxidant compound which is used to prevent lipid peroxidation and shows multiple cytoprotective actions. It is an activator of Nrf2.
Cancer Commun (Lond), 2025, 10.1002/cac2.70036
Mol Med, 2025, 31(1):1
J Zhejiang Univ Sci B, 2025, 26(9):881-896
S2586 DMF (Dimethyl Fumarate) Dimethyl Fumarate (DMF), the methyl ester of fumaric acid, is used to treat people with relapsing forms of multiple sclerosis. It is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression.
J Clin Invest, 2025, 135(14)e176655
Neural Regen Res, 2025, 10.4103/NRR.NRR-D-24-01469
Chin Med, 2025, 20(1):61
Verified customer review of DMF (Dimethyl Fumarate)
S7864 Oltipraz Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.
Int Immunopharmacol, 2024, 143(Pt 1):113346
J Neuroinflammation, 2023, 20(1):212
PLoS Genet, 2022, 18(3):e1010128
Verified customer review of Oltipraz
S6647 Bardoxolone (CDDO) Bardoxolone (CDDO), acts by releasing Nrf2 from KEAP1,is a highly potent activator of Nrf2 that induce programmed cell death (apoptosis) in cancer cells.
J Clin Invest, 2025, 135(14)e176655
Sci Rep, 2025, 15(1):21271
Int J Mol Sci, 2024, 25(15)8046
S5929 4-Octyl Itaconate 4-Octyl Itaconate activates Nrf2 signaling to inhibit the production of pro-inflammatory cytokines in human macrophages and systemic lupus erythematosus (SLE) patient-derived PBMCs.
Clin Transl Med, 2025, 15(7):e70419
Biochem Biophys Res Commun, 2025, 747:151292
Cell Death Dis, 2022, 13(6):521