For research use only. Not for use in humans.

Canakinumab (Anti-IL-1b)

Synonyms: Ilaris Cat.No.A2446 Purity:99%

Canakinumab (Anti-IL-1b) is a recombinant human anti-IL-1β monoclonal antibody targeting IL-1β and neutralizing IL-1β signaling. It can be used in treatment of disorders of autoimmune origin like familial mediterranean fever, mevalonate kinase deficiency, tumor necrosis factor receptor-associated periodic syndrome (TRAPS). MW :145.5 KD.

1 Citation

17 Nobel Prize winners have used Selleck products

Shimon Sakaguchi

Nature Communications 2025,16, Article number:1325

David Baker

Dev Cell 2023, 58(20):2163-2180.e9.

David Julius

Cell 2017, 185-198.e16

Michael Houghton

Cell Chem Biol, 2020, 27(7):780-792.e5

Charles M. Rice

Cell 2018, 172(3):423-438.e25

Quality Control

Batch: Purity: 99% Protein concentration: 7.554mg/ml Endotoxin Level: ＜1EU/mg

Specificity

Name	Citation	IL-6	IL-1	IL-8	IL-12	IL-10	IL-13	IL-2	Others
SKF-86002	0		++
JTE-607 Dihydrochloride	0	+++	+++	+++		+++			TNF-alpha
A-740003	2		++						rat P2X7 receptor,human P2X7 receptor
Apilimod mesylate	3				++++				PIKfyve
MD2-TLR4-IN-1	0	++							TLR4,TNF-α
Danirixin (GSK1325756)	2			++					CXCR2
Resatorvid (TAK-242)	63	++++							TLR4,NO,TNF-α
Apilimod (STA-5326)	18				++++				PIKfyve
LMT-28	0	✔
Atractylodin	0	✔							NAAA
Triolein	0	✔							ROS,MMP-1
Ac-YVAD-cmk	4		✔
Diethyl phosphate	0	✔
RCM-1	5						✔		STAT6,FOXM1,β-catenin
Stylopine	0		✔						COX-2,TNF-α,NO
Myrislignan	1	✔							NF-κB,COX-2,iNOS
NE 52-QQ57	1		✔						iNOS,TNF-α,PGE2
PKR-IN-C16	7		✔						PKR
(3R,8S)-Falcarindiol	3	✔							STAT,ERK,JNK
Gardenoside	0		✔						P2X7 Receptor,P2X3 receptor,NF-κB
T-5224	22		✔						c-Jun,c-Fos/AP-1,Adamts-5
IQ 3	1	✔							TNF-α,JNK3,JNK1
Isuzinaxib (APX-115 free base)	0	✔							TNFα,MCP-1/CCL2,NOX2
AUDA	0		✔						p38,Smad3,TGF-β
SAR-20347	1				✔				IFN-α,TYK2,JAK1
SU 5201	0							✔
Madecassic acid	1		✔						TNF-α,COX-2,iNOS
Homoplantaginin	1	✔							NF-κB,IKKβ,TNF-α
2',5'-Dihydroxyacetophenone	1	✔							NF-κB,ERK1/2,iNOS
Forsythoside B	0	✔							NF-κB,TNF-alpha,IκB
Mulberroside A	0		✔						NF-κB,Caspase-1,NALP3
Chelidonic acid	0	✔							glutamate decarboxylase,Caspase-1,NF-κB
4-Methylesculetin	0	✔							MPO
Muscone	4		✔						TNF-α,NLRP3 inflammasome,NF-κB
Ossirene (AS101)	13		✔
Methylthiouracil	0	✔							ERK1/2,NF-κB,TNF-α

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Canakinumab (Anti-IL-1b) is a recombinant human anti-IL-1β monoclonal antibody targeting IL-1β and neutralizing IL-1β signaling. It can be used in treatment of disorders of autoimmune origin like familial mediterranean fever, mevalonate kinase deficiency, tumor necrosis factor receptor-associated periodic syndrome (TRAPS). MW :145.5 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	914613-48-2
Molecular Weight	145.5 kDa
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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