Home Biosimilar Antibodies Immunology & Inflammation Interleukins Dupilumab (anti-IL-4Rα)
For research use only. Not for use in humans.

Dupilumab (anti-IL-4Rα)

Synonyms: CD124,IL4R

Dupilumab (anti-IL-4Rα) is a fully human anti–interleukin-4 receptor α monoclonal antibody that inhibits both interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling through blockade of the shared IL-4α subunit.

Dupilumab (anti-IL-4Rα)

Click to purchase the isotype control of Dupilumab (anti-IL-4Rα)

1 Citation

The Nobel Prize

17 Nobel Prize winners have used Selleck products

Shimon Sakaguchi

Nature Communications 2025,16, Article number:1325

David Baker

Dev Cell 2023, 58(20):2163-2180.e9.

David Julius

Cell 2017, 185-198.e16

Michael Houghton

Cell Chem Biol, 2020, 27(7):780-792.e5

Charles M. Rice

Cell 2018, 172(3):423-438.e25

Quality Control

Batch: Purity: 99.32% Protein concentration: 5.72 mg/ml Endotoxin Level: <1 EU/mg
99.32

Specificity

Name Citation IL-6 IL-1 IL-8 IL-12 IL-10 IL-13 IL-2 Others
SKF-86002 1
JTE-607 Dihydrochloride 2 TNF-alpha
A-740003 2 rat P2X7 receptor,human P2X7 receptor
Apilimod mesylate 6 PIKfyve
MD2-TLR4-IN-1 2 TLR4,TNF-α
Danirixin (GSK1325756) 2 CXCR2
Resatorvid (TAK-242) 65 TLR4,NO,TNF-α
Apilimod (STA-5326) 19 PIKfyve
LMT-28 1
Atractylodin 0 NAAA
Triolein 0 ROS,MMP-1
Ac-YVAD-cmk 5
Diethyl phosphate 1
RCM-1 5 STAT6,FOXM1,β-catenin
Stylopine 0 COX-2,TNF-α,NO
Myrislignan 1 NF-κB,COX-2,iNOS
NE 52-QQ57 2 iNOS,TNF-α,PGE2
PKR-IN-C16 9 PKR
(3R,8S)-Falcarindiol 3 STAT,ERK,JNK
Gardenoside 1 P2X7 Receptor,P2X3 receptor,NF-κB
T-5224 23 c-Jun,c-Fos/AP-1,Adamts-5
IQ 3 1 TNF-α,JNK3,JNK1
Isuzinaxib (APX-115 free base) 2 TNFα,MCP-1/CCL2,NOX2
AUDA 1 p38,Smad3,TGF-β
SAR-20347 1 IFN-α,TYK2,JAK1
SU 5201 0
Madecassic acid 3 TNF-α,COX-2,iNOS
Homoplantaginin 1 NF-κB,IKKβ,TNF-α
2',5'-Dihydroxyacetophenone 1 NF-κB,ERK1/2,iNOS
Forsythoside B 0 NF-κB,TNF-alpha,IκB
Mulberroside A 0 NF-κB,Caspase-1,NALP3
Chelidonic acid 0 glutamate decarboxylase,Caspase-1,NF-κB
4-Methylesculetin 2 MPO
Muscone 4 TNF-α,NLRP3 inflammasome,NF-κB
Ossirene (AS101) 16
Methylthiouracil 1 ERK1/2,NF-κB,TNF-α
Expand to Check More
1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Dupilumab (anti-IL-4Rα) is a fully human anti–interleukin-4 receptor α monoclonal antibody that inhibits both interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling through blockade of the shared IL-4α subunit.
References

Product Details

CAS No. 1190264-60-8
Molecular Weight 147 KD
Isotype Human IgG4, κ
Source CHO cells
Sterility 0.2 μM filtered
Formulation 100 mM Pro-Ac, 20 mM Arg, pH5.0
Storage
(From the date of receipt)		 Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT06501807 RECRUITING Drug: Biologic treatments available in Chronic Rhinosinusiti Rhinosinusitis Chronic; Nasal Polyps University Hospital, Lille 2024-07-11
NCT05649098 RECRUITING Drug: Dupilumab Skin Diseases Northwestern University 2023-06-12 EARLY_PHASE1
NCT06461897 RECRUITING Drug: Upadacitinib|Drug: Dupilumab Atopic Dermatitis AbbVie 2024-08-19 PHASE3
NCT07352566 NOT_YET_RECRUITING Drug: Triamcinolone|Drug: 5-Fluorouracil|Drug: Calcipotriene Psoriasis; Atopic Dermatitis University of California, San Francisco 2026-08-01 PHASE4
NCT05866562 RECRUITING Drug: Dupilumab|Drug: Placebo Alopecia Areata Icahn School of Medicine at Mount Sinai 2024-07-11 PHASE2
NCT07309614 RECRUITING Drug: Dupilumab Prefilled Syringe|Drug: Placebo Injection Asthma Control Université de Sherbrooke 2026-01-29 PHASE3

(data from https://clinicaltrials.gov, updated on 2026-05-18)

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.