Home Biosimilar Antibodies Immunology & Inflammation Interleukins Levilimab (Anti-IL-6Ra / CD126)
For research use only. Not for use in humans.

Levilimab (Anti-IL-6Ra / CD126)

Synonyms: IL-6， BSF-2

Levilimab (Anti-IL-6Ra / CD126) is a fully human monoclonal antibody targeting interleukin-6 receptor (IL-6R). It is an inflammation-alleviating antibody and can be used for the research of rheumatoid arthritis and covid-19 treatment. MW :145.62 KD.

Levilimab (Anti-IL-6Ra / CD126)

Quality Control

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  • SDS
  • Datasheet
99

Specificity

Name Citation IL-6 IL-1 IL-8 IL-12 IL-10 IL-13 IL-2 Others
SKF-86002 1
JTE-607 Dihydrochloride 2 TNF-alpha
A-740003 2 rat P2X7 receptor,human P2X7 receptor
Apilimod mesylate 6 PIKfyve
MD2-TLR4-IN-1 2 TLR4,TNF-α
Danirixin (GSK1325756) 2 CXCR2
Resatorvid (TAK-242) 65 TLR4,NO,TNF-α
Apilimod (STA-5326) 19 PIKfyve
LMT-28 1
Atractylodin 0 NAAA
Triolein 0 ROS,MMP-1
Ac-YVAD-cmk 5
Diethyl phosphate 1
RCM-1 5 STAT6,FOXM1,β-catenin
Stylopine 0 COX-2,TNF-α,NO
Myrislignan 1 NF-κB,COX-2,iNOS
NE 52-QQ57 2 iNOS,TNF-α,PGE2
PKR-IN-C16 9 PKR
(3R,8S)-Falcarindiol 3 STAT,ERK,JNK
Gardenoside 1 P2X7 Receptor,P2X3 receptor,NF-κB
T-5224 23 c-Jun,c-Fos/AP-1,Adamts-5
IQ 3 1 TNF-α,JNK3,JNK1
Isuzinaxib (APX-115 free base) 2 TNFα,MCP-1/CCL2,NOX2
AUDA 1 p38,Smad3,TGF-β
SAR-20347 1 IFN-α,TYK2,JAK1
SU 5201 0
Madecassic acid 3 TNF-α,COX-2,iNOS
Homoplantaginin 1 NF-κB,IKKβ,TNF-α
2',5'-Dihydroxyacetophenone 1 NF-κB,ERK1/2,iNOS
Forsythoside B 0 NF-κB,TNF-alpha,IκB
Mulberroside A 0 NF-κB,Caspase-1,NALP3
Chelidonic acid 0 glutamate decarboxylase,Caspase-1,NF-κB
4-Methylesculetin 2 MPO
Muscone 4 TNF-α,NLRP3 inflammasome,NF-κB
Ossirene (AS101) 16
Methylthiouracil 1 ERK1/2,NF-κB,TNF-α
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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Levilimab (Anti-IL-6Ra / CD126) is a fully human monoclonal antibody targeting interleukin-6 receptor (IL-6R). It is an inflammation-alleviating antibody and can be used for the research of rheumatoid arthritis and covid-19 treatment. MW :145.62 KD.
References

Product Details

CAS No. 2035008-70-7
Molecular Weight 145.62
Isotype Human IgG1
Source CHO
Purification AKTA
Sterility 0.2 μM filtered
Formulation 100 mM Pro-Ac, 20mM Arg, pH5.0
Storage
(From the date of receipt)		 Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05800327 ACTIVE_NOT_RECRUITING Drug: Levilimab Rheumatoid Arthritis Biocad 2022-12-07 PHASE3
NCT04397562 COMPLETED Drug: Levilimab|Drug: Placebo COVID-19 Biocad 2020-04-29 PHASE3

(data from https://clinicaltrials.gov, updated on 2023-04-05)

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