Home Immunology & Inflammation NOS inhibitor - TNF-alpha inhibitor - Interleukins inhibitor - ERK inhibitor - NF-κB inhibitor 2',5'-Dihydroxyacetophenone For research use only.

2',5'-Dihydroxyacetophenone

Synonyms: DHAP, 2-Acetylhydroquinone, Quinacetophenone

2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers is used in food flavouring. 2',5'-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression. 2',5'-Dihydroxyacetophenone significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways.

2',5'-Dihydroxyacetophenone Chemical Structure

2',5'-Dihydroxyacetophenone Chemical Structure

CAS: 490-78-8

Selleck's 2',5'-Dihydroxyacetophenone has been cited by 1 publication

Purity & Quality Control

Batch: S937401 DMSO] 30 mg/mL] false] ] ] false] ] ] false Purity: 99.78%
99.78

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Biological Activity

Description 2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers is used in food flavouring. 2',5'-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression. 2',5'-Dihydroxyacetophenone significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways.
Targets
iNOS [1] ERK1/2 [1] NF-κB [1] TNF-α [1] IL-6 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04091490 Completed
Hodgkin Lymphoma
State Budgetary Healthcare Institution National Medical Surgical Center N.A. N.I. Pirogov Ministry of Health of Russia
 February 19 2020 Phase 2
NCT03356054 Recruiting
DLBCL
Stichting Hemato-Oncologie voor Volwassenen Nederland
 March 5 2018 Phase 1|Phase 2
NCT02374424 Terminated
Diffuse Large B-Cell Lymphoma
Fondazione Italiana Linfomi - ETS
 November 5 2014 Phase 2

Chemical Information & Solubility

Molecular Weight 152.15 Formula

C8H8O3
CAS No. 490-78-8 SDF --
Smiles CC(=O)C1=C(C=CC(=C1)O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
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DMSO : 30 mg/mL ( (197.17 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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