Home Immunology & Inflammation NOS inhibitor 2',5'-Dihydroxyacetophenone

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2',5'-Dihydroxyacetophenone NOS inhibitor

Cat.No.S9374

2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers is used in food flavouring. This compound significantly inhibits NO production via the suppression of iNOS expression. It significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways.
2',5'-Dihydroxyacetophenone NOS inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 152.15

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Quality Control

Batch: S937401 DMSO]30 mg/mL]false]]]false]]]false Purity: 99.78%
99.78

Solubility

In vitro
Batch:

DMSO : 30 mg/mL (197.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 152.15 Formula

C8H8O3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 490-78-8 -- Storage of Stock Solutions

Synonyms DHAP, 2-Acetylhydroquinone, Quinacetophenone Smiles CC(=O)C1=C(C=CC(=C1)O)O

Mechanism of Action

Targets/IC50/Ki
iNOS
ERK1/2
NF-κB
TNF-α
IL-6
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04091490 Completed
Hodgkin Lymphoma
State Budgetary Healthcare Institution National Medical Surgical Center N.A. N.I. Pirogov Ministry of Health of Russia
 February 19 2020 Phase 2
NCT03356054 Recruiting
DLBCL
Stichting Hemato-Oncologie voor Volwassenen Nederland
 March 5 2018 Phase 1|Phase 2
NCT02374424 Terminated
Diffuse Large B-Cell Lymphoma
Fondazione Italiana Linfomi - ETS
 November 5 2014 Phase 2

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