Home Biosimilar Antibodies Immunology & Inflammation Interleukins Itepekimab (Anti-IL-33)
For research use only. Not for use in humans.

Itepekimab (Anti-IL-33)

Synonyms: REGN-3500, SAR-440340

Itepekimab (Anti-IL-33) is a monoclonal antibody against IL-33. Itepekimab reduces airway inflammation and related tissue damage in previous clinical studies. MW: 145.5 kD.

Itepekimab (Anti-IL-33)

Quality Control

Batch: Purity: 99% Protein concentration: 5.773mg/ml Endotoxin Level: ＜1EU/mg
99

Specificity

Name Citation IL-6 IL-1 IL-8 IL-12 IL-10 IL-13 IL-2 Others
SKF-86002 1
JTE-607 Dihydrochloride 2 TNF-alpha
A-740003 2 rat P2X7 receptor,human P2X7 receptor
Apilimod mesylate 6 PIKfyve
MD2-TLR4-IN-1 2 TLR4,TNF-α
Danirixin (GSK1325756) 2 CXCR2
Resatorvid (TAK-242) 65 TLR4,NO,TNF-α
Apilimod (STA-5326) 19 PIKfyve
LMT-28 1
Atractylodin 0 NAAA
Triolein 0 ROS,MMP-1
Ac-YVAD-cmk 5
Diethyl phosphate 1
RCM-1 5 STAT6,FOXM1,β-catenin
Stylopine 0 COX-2,TNF-α,NO
Myrislignan 1 NF-κB,COX-2,iNOS
NE 52-QQ57 2 iNOS,TNF-α,PGE2
PKR-IN-C16 9 PKR
(3R,8S)-Falcarindiol 3 STAT,ERK,JNK
Gardenoside 1 P2X7 Receptor,P2X3 receptor,NF-κB
T-5224 23 c-Jun,c-Fos/AP-1,Adamts-5
IQ 3 1 TNF-α,JNK3,JNK1
Isuzinaxib (APX-115 free base) 2 TNFα,MCP-1/CCL2,NOX2
AUDA 1 p38,Smad3,TGF-β
SAR-20347 1 IFN-α,TYK2,JAK1
SU 5201 0
Madecassic acid 3 TNF-α,COX-2,iNOS
Homoplantaginin 1 NF-κB,IKKβ,TNF-α
2',5'-Dihydroxyacetophenone 1 NF-κB,ERK1/2,iNOS
Forsythoside B 0 NF-κB,TNF-alpha,IκB
Mulberroside A 0 NF-κB,Caspase-1,NALP3
Chelidonic acid 0 glutamate decarboxylase,Caspase-1,NF-κB
4-Methylesculetin 2 MPO
Muscone 4 TNF-α,NLRP3 inflammasome,NF-κB
Ossirene (AS101) 16
Methylthiouracil 1 ERK1/2,NF-κB,TNF-α
Expand to Check More
1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Itepekimab (Anti-IL-33) is a monoclonal antibody against IL-33. Itepekimab reduces airway inflammation and related tissue damage in previous clinical studies. MW: 145.5 kD.

Product Details

CAS No.  2226742-52-3
Molecular Weight 145.5 kDa
Isotype Human IgG4SP
Source CHO
Purification AKTA
Sterility 0.2 μM filtered
Formulation 100 mM Pro-Ac, 20mM Arg, pH5.0
Storage
(From the date of receipt)		 Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT07484230 WITHDRAWN Drug: Itepekimab (SAR440340)|Drug: Placebo Chronic Rhinosinusitis With Nasal Polyps Sanofi 2026-05-08 PHASE3
NCT07424144 ACTIVE_NOT_RECRUITING Drug: Itepekimab (SAR440340)|Drug: Placebo Chronic Rhinosinusitis With Nasal Polyps Sanofi 2026-03-12 PHASE3
NCT06208306 ACTIVE_NOT_RECRUITING Drug: Itepekimab (SAR440340)|Drug: Placebo Chronic Obstructive Pulmonary Disease Sanofi 2024-01-11 PHASE3
NCT06834360 ACTIVE_NOT_RECRUITING Drug: Itepekimab (SAR440340)|Drug: Placebo|Drug: Mometasone Chronic Rhinosinusitis With Nasal Polyps Sanofi 2025-02-06 PHASE3
NCT06834347 ACTIVE_NOT_RECRUITING Drug: Itepekimab (SAR440340)|Drug: Placebo|Drug: Mometasone Chronic Rhinosinusitis With Nasal Polyps Sanofi 2025-02-12 PHASE3
NCT06691113 COMPLETED Drug: Itepekimab (SAR440340)|Drug: Placebo|Drug: Mometasone Chronic Rhinosinusitis Without Nasal Polyps Sanofi 2024-12-16 PHASE2

(data from https://clinicaltrials.gov, updated on 2026-08-13)

Tech Support

Handling Instructions

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