Estradiol

Catalog No.S1709

Estradiol Chemical Structure

Molecular Weight(MW): 272.38

Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone.

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In DMSO USD 270 In stock
USD 97 In stock
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Biological Activity

Description Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone.
Targets
Estrogen receptor [1]
In vitro

Estradiol induces new dendritic spines and synapses on hippocampal CA1 pyramidal cells. Estradiol treatment resulted in a 46% increase in NMDA receptor binding. Estradiol treatment increases NMDA receptor binding in parallel with dendritic spine and synapse density. Estradiol treatment results in increased sensitivity of CA1 pyramidal cells to NMDA receptor-mediated synaptic input and that this increase is well correlated with the estradiol-induced increase in dendritic spine density in the apical dendritic tree of these cells. [1] 17 beta-estradiol is found to reduce Ba2+ entry reversibly via Ca2+ channels in acutely dissociated and cultured neostriatal neurons. 17 alpha-Estradiol also reduces Ba2+ currents but is significantly less effective than 17 beta-estradiol in rat neostriatal neurons. [2] 17 beta-estradiol exerts a dose-dependent inhibition of IL-1-, TNF-, and IL-1 and TNF-induced production of bioassayable IL-6. Estradiol inhibits both TNF-induced IL-6 production and osteoclast development in primary bone cell cultures derived from neonatal murine calvaria. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF-7 cells NUjqNXZVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGLCNGNIem:5dHigdoV{eG:wc3WgbY4h[3WudIXy[ZMhd2ZiTVPGMVchMGi3bXHuJIJz\WG|dDDjZY5k\XJiY3XscEBtcW6nKTDj[YxteyxiRVO1NF0yNjV{ZT2wOkDPxE1? NHzoVIs6OzV5NUOz
human MCF7 cells M2\ySWZ2dmO2aX;uJIF{e2G7 MX[2JIRigXN? NUXwXXJTTXO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJINmdGxicILvcIln\XKjdHnvckBi\nSncjC2JIRigXNiYomgW3NVQCCjc4PhfUwhTUN3ME2zMldmNTB4IN88US=> M1XUOFE5PzZyNkCz
human U2-OS cells MoXYSpVv[3Srb36gZZN{[Xl? MkfRRYN1cX[jdHnvckBw\iCqdX3hckBGWmGucHjhJIV5eHKnc4Pl[EBqdiCqdX3hckBWOi2RUzDj[YxteyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZkhemWuYYTpeoUhfG9idX70doVifGWmIHPvcpRzd2xuIFXDOVA:PGVvME[g{txO NFnsZY8zOzB2M{K0Ni=>
MCF7 cells M1vWfHBzd2yrZnXyZZRqd25iYYPzZZk> NXj5cll[PzJiaB?= MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHXzeJJw\2WwLXTl[olkcWWwdDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFXDOVA:Pi52ZT2wOkDPxE1? MUeyNlQ3PDZ6MR?=
HeLa cells NGruepVHfW6ldHnvckBie3OjeR?= MUDBZ5RqfmG2aX;uJI9nKGW|dILv[4VvKHKnc4DvcpNmKGWuZX3lcpQhcW5iSHXMZUBk\WyuczDzeIFjdHlidILhcpNn\WO2ZXSge4l1cCCqdX3hckBGe3S{b3flckBz\WOncITvdkBidHCqYTygSWM2OD1{ZT2wOUDPxE1? M{PzRVEyQTB4Mkiw
HEK293 cells NHfYTm1HfW6ldHnvckBie3OjeR?= NWXveHN7SWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBGWmGucHjhJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTJwNHWtNFUh|ryP M3riZVI2OzB3Nki4
human Ishikawa cells MkXPSpVv[3Srb36gZZN{[Xl? MkLZO|IhcA>? NYfFVZZXTXO2cn;n[Y5q[yCjY4Tpeol1gSCjdDDld5Rzd2enbjDy[YNmeHSxcjDpckBpfW2jbjDJd4hqc2G5YTDj[YxteyCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4Yh[WytYXzpcoUheGixc4DoZZRie2ViZYjwdoV{e2mxbjDh[pRmeiB5MjDodpMh[nlibXnjdo9xdGG2ZTDy[YFl\XJuIFXDOVA:Oi52NnWtNFUh|ryP NWftO|FCOjJ2NkS2PFE>
CHO-K1 cells MnXqSpVv[3Srb36gZZN{[Xl? M{fueFI1KGh? NWfUXlRNXHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hd2ZiRWLi[ZRiKHKnY3XweI9zKGW6cILld5Nm\CCrbjDDTG8uUzFiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0{Nj[nLUC1JO69VQ>? MVWyNlY1PzJzNx?=
T47D cells MVrGeY5kfGmxbjDhd5NigQ>? NIXZXWFC\2:waYP0JIVn\mWldDDvckB1emGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBqdiCWNEfEJINmdGy|IHX4dJJme3Orbneg[ZN1em:pZX6gdoVk\XC2b4KgZYxxcGFuIFXDOVA:P2VvMEWg{txO M1LZNlEzPDV7MEG3
human HEC1 cells M3vMbGZ2dmO2aX;uJIF{e2G7 M4[xVVI1KGh? NV7vNGdmSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBnfWyuLXzlcod1cCCHUnHsdIhiKHKnY3XweI9zKGW6cILld5Nm\CCrbjDoeY1idiCKRVOxJINmdGy|IHPvMYV5eHKnc4PpcochMEWURTmyMZBUOi2udXOg[4Vv\SCjc4Pld5Nm\CCjczD0doFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDh[pRmeiB{NDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUnlMVA2KM7:TR?= MmG4NlE1QDF2OUe=
human SK-BR-3 cells NE\sWFZHfW6ldHnvckBie3OjeR?= MXq0PEBp NUG1RmRtUW6qaXLpeIlwdiCxZjDjbIVud2G2dILhZ5RidnRvaX7keYNm\CClZXzsJI1q\3KjdHnvckBw\iCqdX3hckBUUy2EUj2zJINmdGy|IHHmeIVzKDR6IHjyd{BjgSC2cnHud5dmdGxibXnndoF1cW:wIHHzd4F6NCCLQ{WwQVAvOSCwTR?= Mln5NVY2OjB5M{O=
UAS cells NVTRe3huTnWwY4Tpc44h[XO|YYm= NYTDWldYOThiaB?= NV32fZo4SWexbnnzeEBi[3Srdnn0fUBifCCHUnLleIEh\XiycnXzd4VlKGmwIGXBV{Bk\WyuczDjc{1mgHC{ZYPzbY5oKGKndHGtcIFkfGGvYYPlJIFnfGW{IEG4JIhzeyCkeTDi[ZRiNWyjY4ThcYF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTBwMkWgcm0> NYnJeIpTOjF6OEWyO|k>
COS7 cells NXPuR|E6TnWwY4Tpc44h[XO|YYm= M1LRfGRqe3CuYXPlcYVvfCCxZjDFNk1CdGW6YU[zN{Bnem:vIFfGVE11[WepZXSgSXJidHCqYTDlfJBz\XO|ZXSgbY4hS0:VNzDj[YxteyCkeTDGRWNUNCCNaU2wMlMhdk1? M{nDbVE3PTJyN{Oz
AH109 cells MYHGeY5kfGmxbjDhd5NigQ>? NUn5c3N[OjRiaB?= NWrIN5VlSWexbnnzeEBi[3Srdnn0fUBifCCHUnHsdIhiKHKnY3XweI9zKEyERDDlfJBz\XO|ZXSgbY4hgWWjc4SgRWgyODliY3XscJMh[XO|ZYPz[YQh[XNiaX70[ZJi[3Srb36ge4l1cCCVUlOxJIFnfGW{IEK0JIhzeyCkeTDhcJBp[S2pYXzhZ5Rwe2mmYYPlJIF{e2G7LDDFR|UxRTFwMEWgcm0> MYWyNlY1PzJzNx?=
HepG2 cells M4HMXGZ2dmO2aX;uJIF{e2G7 NWXOTY1HOjRiaB?= NHnoOFVC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJGVT[WyyaHGg[ZhxemW|c3XkJIlvKEincFeyJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;Mj6yJI5O MXGyNlI5OzN{OB?=
COS-1 cells MlzqSpVv[3Srb36gZZN{[Xl? MnHFTY4hfmm2cn:gZYdwdmm|dDDhZ5Rqfmm2eTDmc5Ih\XO2cn;n[Y4hemWlZYD0c5Ih[WyyaHGg[ZhxemW|c3XkJIlvKEORUz2xJINmdGy|LDDFR|UxRTJwNDDuUS=> MUOxOVcyOzRyNx?=
SAOS-2 cells NEPydZZHfW6ldHnvckBie3OjeR?= MX3GeY5kfGmxbnHsJGV{fHKxZ3XuJJJm[2WydH;yJIJmfGFiYXP0bZZqfHliYomgcYV1[Wyub4TobY9v\WmwIHnu[JVkfGmxbjDpckBUSU:VLUKgZ4VtdHNuIFXEOVA:PC55IH7N M3HjbVEzQDJ2MESz
MDA-MB-231 cells MXLQdo9tcW[ncnH0bY9vKGG|c3H5 MmLONkBl[Xm| Mly4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgbJVu[W5iRWKtcoVo[XSrdnWgUWRCNU2ELUKzNUBk\WyuczDh[pRmeiB{IHThfZMh[nliTWTUJIF{e2G7LDDJR|UxRTN|LkS2JO69VQ>? MYKyOVIzOjh5Nh?=

... Click to View More Cell Line Experimental Data

In vivo Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. [4] Estradiol alone can reverse the ovariectomy-induced decrease in spine density. Estradiol combined with Progesterone initially increases spine density for a period of 2 to 6 hours but then results in a much sharper decrease than is observed following estradiol alone. [5]

Protocol

Solubility (25°C)

In vitro DMSO 54 mg/mL (198.25 mM)
Ethanol 5 mg/mL (18.35 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 272.38
Formula

C18H24O2

CAS No. 50-28-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03718338 Not yet recruiting Procedure: Evaluation|Other: Quality-of-Life Assessment Prostate Adenocarcinoma University of Washington|National Cancer Institute (NCI) November 30 2019 Not Applicable
NCT04093856 Not yet recruiting -- Diabetes Mellitus|Diabetes Mellitus Type 2|Obesity|Body Weight|Bone Diseases Metabolic|Fractures Bone|Osteoporotic Fractures|Osteoporosis|Quality of Life|Fall|Musculoskeletal Diseases Suzanne Morin|CHU de Quebec-Universite Laval|McGill University Health Centre/Research Institute of the McGill University Health Centre October 2019 --
NCT04007614 Not yet recruiting Other: Questionnaire Contraception|Macro-progestins Assistance Publique - Hôpitaux de Paris September 2019 --
NCT03680053 Not yet recruiting Drug: Duphaston|Drug: Cetrorelix Infertility|ART ShangHai Ji Ai Genetics & IVF Institute September 2019 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID