Estradiol

Catalog No.S1709

Estradiol Chemical Structure

Molecular Weight(MW): 272.38

Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone.

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In DMSO USD 270 In stock
USD 97 In stock
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Biological Activity

Description Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone.
Targets
Estrogen receptor [1]
In vitro

Estradiol induces new dendritic spines and synapses on hippocampal CA1 pyramidal cells. Estradiol treatment resulted in a 46% increase in NMDA receptor binding. Estradiol treatment increases NMDA receptor binding in parallel with dendritic spine and synapse density. Estradiol treatment results in increased sensitivity of CA1 pyramidal cells to NMDA receptor-mediated synaptic input and that this increase is well correlated with the estradiol-induced increase in dendritic spine density in the apical dendritic tree of these cells. [1] 17 beta-estradiol is found to reduce Ba2+ entry reversibly via Ca2+ channels in acutely dissociated and cultured neostriatal neurons. 17 alpha-Estradiol also reduces Ba2+ currents but is significantly less effective than 17 beta-estradiol in rat neostriatal neurons. [2] 17 beta-estradiol exerts a dose-dependent inhibition of IL-1-, TNF-, and IL-1 and TNF-induced production of bioassayable IL-6. Estradiol inhibits both TNF-induced IL-6 production and osteoclast development in primary bone cell cultures derived from neonatal murine calvaria. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF-7 cells Mm\DS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUHHdo94fGhicnXzdI9ve2ViaX6gZ5VtfHW{ZYOgc4YhVUOILUegLIh2dWGwIHLy[YF{fCClYX7j[ZIh[2WubDDsbY5mMSClZXzsd{whTUN3ME2xMlUz\S1yNjFOwG0> MVW5N|U4PTN|
human MCF7 cells MonXSpVv[3Srb36gZZN{[Xl? M4Pt[lYh\GG7cx?= NFHGblhGe3S{b3flcolkKGGldHn2bZR6KGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCycn;sbYZmemG2aX;uJIFnfGW{IE[g[IF6eyCkeTDXV3Q5KGG|c3H5MEBGSzVyPUOuO4UuODZizszN MWSxPFc3ODZyMx?=
human U2-OS cells NWXvdJhqTnWwY4Tpc44h[XO|YYm= NGDTZ5hC[3SrdnH0bY9vKG:oIHj1cYFvKEWUYXzwbIEh\XiycnXzd4VlKGmwIHj1cYFvKFV{LV;TJINmdGy|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSC{ZXzheIl3\SC2bzD1cpRz\WG2ZXSgZ49vfHKxbDygSWM2OD12ZT2wOkDPxE1? NVrTWHNnOjNyNEOyOFI>
MCF7 cells NXvSbZBPWHKxbHnm[ZJifGmxbjDhd5NigQ>? M4jVeVczKGh? MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHXzeJJw\2WwLXTl[olkcWWwdDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFXDOVA:Pi52ZT2wOkDPxE1? NU\PWFRuOjJ2NkS2PFE>
HeLa cells MnHoSpVv[3Srb36gZZN{[Xl? MWHBZ5RqfmG2aX;uJI9nKGW|dILv[4VvKHKnc4DvcpNmKGWuZX3lcpQhcW5iSHXMZUBk\WyuczDzeIFjdHlidILhcpNn\WO2ZXSge4l1cCCqdX3hckBGe3S{b3flckBz\WOncITvdkBidHCqYTygSWM2OD1{ZT2wOUDPxE1? Mmf1NVE6ODZ{OEC=
HEK293 cells MYnGeY5kfGmxbjDhd5NigQ>? MXzB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIFXSZYxxcGFiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9Nk41\S1yNTFOwG0> Mn;GNlU{ODV4OEi=
human Ishikawa cells M1jsZWZ2dmO2aX;uJIF{e2G7 M2X5[VczKGh? NHfnOIRGe3S{b3flcolkKGGldHn2bZR6KGG2IHXzeJJw\2WwIILlZ4VxfG:{IHnuJIh2dWGwIFnzbIls[XejIHPlcIx{KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBidGujbHnu[UBxcG:|cHjheIF{\SCneIDy[ZN{cW:wIHHmeIVzKDd{IHjyd{BjgSCvaXPyc5Bt[XSnIILlZYRmeixiRVO1NF0zNjR4ZT2wOUDPxE1? NEnsfVczOjR4NE[4NS=>
CHO-K1 cells MWrGeY5kfGmxbjDhd5NigQ>? MUOyOEBp NUfqPFVRXHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hd2ZiRWLi[ZRiKHKnY3XweI9zKGW6cILld5Nm\CCrbjDDTG8uUzFiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0{Nj[nLUC1JO69VQ>? NXnJT3g1OjJ4NEeyNVc>
T47D cells NGqzXmlHfW6ldHnvckBie3OjeR?= NYf6NVNWSWexbnnzeEBm\m[nY4Sgc44hfHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iVES3SEBk\WyuczDlfJBz\XO|aX7nJIV{fHKxZ3XuJJJm[2WydH;yJIFteGijLDDFR|UxRTenLUC1JO69VQ>? M1ywNVEzPDV7MEG3
human HEC1 cells MXrGeY5kfGmxbjDhd5NigQ>? M3\4R|I1KGh? NWrER3ZzSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBnfWyuLXzlcod1cCCHUnHsdIhiKHKnY3XweI9zKGW6cILld5Nm\CCrbjDoeY1idiCKRVOxJINmdGy|IHPvMYV5eHKnc4PpcochMEWURTmyMZBUOi2udXOg[4Vv\SCjc4Pld5Nm\CCjczD0doFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDh[pRmeiB{NDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUnlMVA2KM7:TR?= NEP6dnMzOTR6MUS5Oy=>
human SK-BR-3 cells NHztR|hHfW6ldHnvckBie3OjeR?= MoixOFghcA>? M1\aTWlvcGmkaYTpc44hd2ZiY3jlcY9ifHS{YXP0ZY51NWmwZIXj[YQh[2WubDDtbYdz[XSrb36gc4YhcHWvYX6gV2suSlJvMzDj[YxteyCjZoTldkA1QCCqcoOgZpkhfHKjboP3[YxtKG2rZ4LheIlwdiCjc4PhfUwhUUN3ME2wMlEhdk1? MX2xOlUzODd|Mx?=
UAS cells NEnmfFJHfW6ldHnvckBie3OjeR?= NFvy[40yQCCq NIrrTHFC\2:waYP0JIFkfGm4aYT5JIF1KEWUYnX0ZUBmgHC{ZYPz[YQhcW5iVVHTJINmdGy|IHPvMYV5eHKnc4Ppcoch[mW2YT3sZYN1[W2jc3WgZYZ1\XJiMUigbJJ{KGK7IHLleIEudGGldHHtZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5{NTDuUS=> M4XzOVIyQDh3Mke5
COS7 cells NUj6b2NiTnWwY4Tpc44h[XO|YYm= M3PSPGRqe3CuYXPlcYVvfCCxZjDFNk1CdGW6YU[zN{Bnem:vIFfGVE11[WepZXSgSXJidHCqYTDlfJBz\XO|ZXSgbY4hS0:VNzDj[YxteyCkeTDGRWNUNCCNaU2wMlMhdk1? NULLbY5oOTZ3MkC3N|M>
AH109 cells M37ZXmZ2dmO2aX;uJIF{e2G7 MYKyOEBp NWPjUI9DSWexbnnzeEBi[3Srdnn0fUBifCCHUnHsdIhiKHKnY3XweI9zKEyERDDlfJBz\XO|ZXSgbY4hgWWjc4SgRWgyODliY3XscJMh[XO|ZYPz[YQh[XNiaX70[ZJi[3Srb36ge4l1cCCVUlOxJIFnfGW{IEK0JIhzeyCkeTDhcJBp[S2pYXzhZ5Rwe2mmYYPlJIF{e2G7LDDFR|UxRTFwMEWgcm0> Mmm4NlI3PDd{MUe=
HepG2 cells M{TQRWZ2dmO2aX;uJIF{e2G7 MoTSNlQhcA>? M3Hac2Fod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gSXJidHCqYTDlfJBz\XO|ZXSgbY4hUGWyR{KgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1{LkKgcm0> M2LU[|IzOjh|M{K4
COS-1 cells MoLmSpVv[3Srb36gZZN{[Xl? M{Pz[GlvKH[rdILvJIFod26rc4SgZYN1cX[rdImg[o9zKGW|dILv[4VvKHKnY3XweI9zKGGucHjhJIV5eHKnc4Pl[EBqdiCFT2OtNUBk\WyuczygSWM2OD1{LkSgcm0> NI\IcVcyPTdzM{SwOy=>
SAOS-2 cells M2jYXmZ2dmO2aX;uJIF{e2G7 NYi5RXUyTnWwY4Tpc45idCCHc4Tyc4dmdiC{ZXPldJRweiCkZYThJIFkfGm4aYT5JIJ6KG2ndHHscI91cGmxbnXpckBqdmS3Y4Tpc44hcW5iU1HPV{0zKGOnbHzzMEBGTDVyPUSuO{BvVQ>? MkT0NVI5OjRyNEO=
MDA-MB-231 cells M2TmZXBzd2yrZnXyZZRqd25iYYPzZZk> NXOwR5RQOiCmYYnz M3zleGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIh2dWGwIFXSMY5m\2G2aY\lJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiMjDkZZl{KGK7IF3UWEBie3OjeTygTWM2OD1|Mz60OkDPxE1? NGrkdXYzPTJ{Mki3Oi=>

... Click to View More Cell Line Experimental Data

In vivo Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. [4] Estradiol alone can reverse the ovariectomy-induced decrease in spine density. Estradiol combined with Progesterone initially increases spine density for a period of 2 to 6 hours but then results in a much sharper decrease than is observed following estradiol alone. [5]

Protocol

Solubility (25°C)

In vitro DMSO 54 mg/mL (198.25 mM)
Ethanol 5 mg/mL (18.35 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 272.38
Formula

C18H24O2

CAS No. 50-28-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03385551 Not yet recruiting Vulvovaginal Atrophy Instituto Palacios December 9 2019 --
NCT03385551 Not yet recruiting Vulvovaginal Atrophy Instituto Palacios December 9 2019 --
NCT03749733 Not yet recruiting Bioequivalence Grünenthal GmbH|Grünenthal S.A. October 2019 Phase 1
NCT03749733 Not yet recruiting Bioequivalence Grünenthal GmbH|Grünenthal S.A. October 2019 Phase 1
NCT03868202 Not yet recruiting Follicle Stimulating Hormone Glycosylation|Urinary FSH21/FSH24 Ratio|Estradiol Effect Eastern Virginia Medical School|Wichita State University April 2019 Phase 2
NCT03557619 Not yet recruiting Hematologic Malignancies AbbVie April 5 2019 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID