Estradiol

Catalog No.S1709

Estradiol Chemical Structure

Molecular Weight(MW): 272.38

Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone.

Size Price Stock Quantity  
In DMSO USD 270 In stock
USD 97 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone.
Targets
Estrogen receptor [1]
In vitro

Estradiol induces new dendritic spines and synapses on hippocampal CA1 pyramidal cells. Estradiol treatment resulted in a 46% increase in NMDA receptor binding. Estradiol treatment increases NMDA receptor binding in parallel with dendritic spine and synapse density. Estradiol treatment results in increased sensitivity of CA1 pyramidal cells to NMDA receptor-mediated synaptic input and that this increase is well correlated with the estradiol-induced increase in dendritic spine density in the apical dendritic tree of these cells. [1] 17 beta-estradiol is found to reduce Ba2+ entry reversibly via Ca2+ channels in acutely dissociated and cultured neostriatal neurons. 17 alpha-Estradiol also reduces Ba2+ currents but is significantly less effective than 17 beta-estradiol in rat neostriatal neurons. [2] 17 beta-estradiol exerts a dose-dependent inhibition of IL-1-, TNF-, and IL-1 and TNF-induced production of bioassayable IL-6. Estradiol inhibits both TNF-induced IL-6 production and osteoclast development in primary bone cell cultures derived from neonatal murine calvaria. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF-7 cells M3rMN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF7IfZNIem:5dHigdoV{eG:wc3WgbY4h[3WudIXy[ZMhd2ZiTVPGMVchMGi3bXHuJIJz\WG|dDDjZY5k\XJiY3XscEBtcW6nKTDj[YxteyxiRVO1NF0yNjV{ZT2wOkDPxE1? NWrKeW4xQTN3N{WzNy=>
human MCF7 cells MnvCSpVv[3Srb36gZZN{[Xl? M4q0bVYh\GG7cx?= MnnvSZN1em:pZX7pZ{Bi[3Srdnn0fUBqdiCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB4IHThfZMh[nliV2PUPEBie3OjeTygSWM2OD1|LkflMVA3KM7:TR?= NX;tZXB2OTh5NkC2NFM>
human U2-OS cells NVrVPGxHTnWwY4Tpc44h[XO|YYm= NYXOWYpYSWO2aY\heIlwdiCxZjDoeY1idiCHUnHsdIhiKGW6cILld5Nm\CCrbjDoeY1idiCXMj3PV{Bk\WyuczDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XlicnXsZZRqfmVidH:geY51emWjdHXkJINwdnS{b3ysJGVEPTB;NHWtNFYh|ryP M4fBOlI{ODR|MkSy
MCF7 cells M3nucXBzd2yrZnXyZZRqd25iYYPzZZk> MnzRO|IhcA>? NFe0b2FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIV{fHKxZ3XuMYRm\mmlaXXueEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGVEPTB;Nj60[U0xPiEQvF2= NWTkUIFIOjJ2NkS2PFE>
HeLa cells NULm[FY2TnWwY4Tpc44h[XO|YYm= MWHBZ5RqfmG2aX;uJI9nKGW|dILv[4VvKHKnc4DvcpNmKGWuZX3lcpQhcW5iSHXMZUBk\WyuczDzeIFjdHlidILhcpNn\WO2ZXSge4l1cCCqdX3hckBGe3S{b3flckBz\WOncITvdkBidHCqYTygSWM2OD1{ZT2wOUDPxE1? NGPXRW0yOTlyNkK4NC=>
HEK293 cells M2rrPGZ2dmO2aX;uJIF{e2G7 MWfB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIFXSZYxxcGFiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9Nk41\S1yNTFOwG0> MYiyOVMxPTZ6OB?=
human Ishikawa cells NEjKUJRHfW6ldHnvckBie3OjeR?= M4\ydlczKGh? NFiwcYdGe3S{b3flcolkKGGldHn2bZR6KGG2IHXzeJJw\2WwIILlZ4VxfG:{IHnuJIh2dWGwIFnzbIls[XejIHPlcIx{KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBidGujbHnu[UBxcG:|cHjheIF{\SCneIDy[ZN{cW:wIHHmeIVzKDd{IHjyd{BjgSCvaXPyc5Bt[XSnIILlZYRmeixiRVO1NF0zNjR4ZT2wOUDPxE1? M1X5[FIzPDZ2Nkix
CHO-K1 cells MUPGeY5kfGmxbjDhd5NigQ>? NUnDT25MOjRiaB?= MVfUdoFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDv[kBGWmKndHGgdoVk\XC2b4Kg[ZhxemW|c3XkJIlvKEOKTz3LNUBk\WyuczDh[pRmeiB{NDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUOuOoUuODVizszN M{jWelIzPjR5MkG3
T47D cells NXLzXlROTnWwY4Tpc44h[XO|YYm= MnLwRYdwdmm|dDDl[oZm[3Rib36geJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gbY4hXDR5RDDj[YxteyCneIDy[ZN{cW6pIHXzeJJw\2WwIILlZ4VxfG:{IHHsdIhiNCCHQ{WwQVdmNTB3IN88US=> M3\xUVEzPDV7MEG3
human HEC1 cells NWnnTm9MTnWwY4Tpc44h[XO|YYm= MmTyNlQhcA>? NH3nRZhC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJIZ2dGxvbHXu[5RpKEWUYXzwbIEhemWlZYD0c5Ih\XiycnXzd4VlKGmwIHj1cYFvKEiHQ{GgZ4VtdHNiY3:t[ZhxemW|c3nu[{ApTVKHKUKtdHMzNWy3YzDn[Y5mKGG|c3Xzd4VlKGG|IITyZY5{[3KrcITpc45idCCjY4TpeoF1cW:wIHHmeIVzKDJ2IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;OXWtNFUh|ryP M4\KelIyPDhzNEm3
human SK-BR-3 cells MWnGeY5kfGmxbjDhd5NigQ>? MXW0PEBp MW\Jcohq[mm2aX;uJI9nKGOqZX3vZZR1emGldHHueE1qdmS3Y3XkJINmdGxibXnndoF1cW:wIH;mJIh2dWGwIGPLMWJTNTNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JJRz[W6|d3XscEBucWe{YYTpc44h[XO|YYmsJGlEPTB;MD6xJI5O M4rXdVE3PTJyN{Oz
UAS cells M1H5PGZ2dmO2aX;uJIF{e2G7 MUmxPEBp MUXB[49vcXO2IHHjeIl3cXS7IHH0JGVT[mW2YTDlfJBz\XO|ZXSgbY4hXUGVIHPlcIx{KGOxLXX4dJJme3OrbnegZoV1[S2uYXP0ZY1ie2ViYX\0[ZIhOThiaILzJIJ6KGKndHGtcIFkfGGvYYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9NE4zPSCwTR?= NIL2SYczOTh6NUK3PS=>
COS7 cells MXTGeY5kfGmxbjDhd5NigQ>? Moq1SIl{eGyjY3Xt[Y51KG:oIFWyMWFt\XijNkOzJIZzd21iR1\QMZRi\2enZDDFVoFteGijIHX4dJJme3OnZDDpckBEV1N5IHPlcIx{KGK7IF\BR3MtKEurPUCuN{BvVQ>? M1PFUFE3PTJyN{Oz
AH109 cells M1ruNWZ2dmO2aX;uJIF{e2G7 M3KzclI1KGh? MkDGRYdwdmm|dDDhZ5Rqfmm2eTDheEBGWmGucHjhJJJm[2WydH;yJGxDTCCneIDy[ZN{\WRiaX6gfYVie3RiQVixNFkh[2WubIOgZZN{\XO|ZXSgZZMhcW62ZYLhZ5Rqd25id3n0bEBUWkNzIHHmeIVzKDJ2IHjyd{BjgSCjbIDoZU1o[WyjY4Tvd4ll[XOnIHHzd4F6NCCHQ{WwQVEvODVibl2= NX:5N3BJOjJ4NEeyNVc>
HepG2 cells NF\YV41HfW6ldHnvckBie3OjeR?= MXmyOEBp MlznRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDFVoFteGijIHX4dJJme3OnZDDpckBJ\XCJMjDj[YxteyCjZoTldkAzPCCqcoOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTJwMjDuUS=> M1Lob|IzOjh|M{K4
COS-1 cells MWPGeY5kfGmxbjDhd5NigQ>? MVXJckB3cXS{bzDh[49vcXO2IHHjeIl3cXS7IH\vdkBme3S{b3flckBz\WOncITvdkBidHCqYTDlfJBz\XO|ZXSgbY4hS0:VLUGgZ4VtdHNuIFXDOVA:Oi52IH7N M3vKRlE2PzF|NEC3
SAOS-2 cells NES4VY5HfW6ldHnvckBie3OjeR?= M2PTRWZ2dmO2aX;uZYwhTXO2cn;n[Y4hemWlZYD0c5Ih[mW2YTDhZ5Rqfmm2eTDifUBu\XSjbHzveIhqd26naX6gbY5lfWO2aX;uJIlvKFODT2OtNkBk\WyuczygSWQ2OD12Lkegcm0> MmLXNVI5OjRyNEO=
MDA-MB-231 cells M3PqT3Bzd2yrZnXyZZRqd25iYYPzZZk> Mk[3NkBl[Xm| NGLkN3hCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBpfW2jbjDFVk1v\WejdHn2[UBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IEKg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTB;M{OuOFYh|ryP NFrp[IozPTJ{Mki3Oi=>

... Click to View More Cell Line Experimental Data

In vivo Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. [4] Estradiol alone can reverse the ovariectomy-induced decrease in spine density. Estradiol combined with Progesterone initially increases spine density for a period of 2 to 6 hours but then results in a much sharper decrease than is observed following estradiol alone. [5]

Protocol

Solubility (25°C)

In vitro DMSO 54 mg/mL (198.25 mM)
Ethanol 5 mg/mL (18.35 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 272.38
Formula

C18H24O2

CAS No. 50-28-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02668822 Terminated Dysmenorrhea Merck Sharp & Dohme Corp. February 9 2016 Phase 3
NCT01923298 Active not recruiting Estrogen Levels Among Breast Cancer Patients University of Arizona August 9 2013 Phase 2
NCT03547024 Completed Healthy Janssen-Cilag International NV June 8 2018 Phase 1
NCT03544762 Recruiting Breast Cancer National Taiwan University Hospital September 8 2017 Phase 3
NCT01753102 Terminated Vulvar Atrophy|Vaginal Atrophy Sun Pharmaceutical Industries Limited November 6 2012 Phase 3
NCT01942668 Completed Menopause TherapeuticsMD August 5 2013 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Estrogen/progestogen Receptor Signaling Pathway Map

Related Estrogen/progestogen Receptor Products

Tags: buy Estradiol | Estradiol ic50 | Estradiol price | Estradiol cost | Estradiol solubility dmso | Estradiol purchase | Estradiol manufacturer | Estradiol research buy | Estradiol order | Estradiol mouse | Estradiol chemical structure | Estradiol mw | Estradiol molecular weight | Estradiol datasheet | Estradiol supplier | Estradiol in vitro | Estradiol cell line | Estradiol concentration | Estradiol nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID