For research use only.

Catalog No.S8133 Synonyms: R-848

3 publications

Resiquimod Chemical Structure

Molecular Weight(MW): 314.38

Resiquimod is an immune response modifier that acts as a potent TLR 7/8 agonist. Phase 2.

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Description Resiquimod is an immune response modifier that acts as a potent TLR 7/8 agonist. Phase 2.
TLR7 [1] TLR8 [1]
In vitro

Resiquimod activates immune cells and induces proliferation of wild-type splenocytes via the Toll-like receptor 7 (TLR7)-MyD88-dependent signaling pathway. [1] Resiquimod also modulates dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses. [2] Resiquimod induces the differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells, and may improve cancer immunotherapy by reducing immunosuppressive MDSCs. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 cells M{i3SWZ2dmO2aX;uJIF{e2G7 NG\JbIlC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHRNWjdiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyClb3X4dJJme3OrbnegdG5qTnS7Mj3TSWFRKHKncH;yeIVzKGK7IILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MD6yOlAyKM7:TR?= NVvCOFJNOjB{M{K4NlQ>
HEK293 cells M3vafWZ2dmO2aX;uJIF{e2G7 Ml63NlQhcA>? MoTuRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDUUHIuPyCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGGodHXyJFI1KGi{czDifUBUTUGSIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MT61JO69VQ>? M4DKdVI1Ozh|NEe1
human PBMC MXHGeY5kfGmxbjDhd5NigQ>? MYCyOEBp NVXte|dtUW6lcnXhd4UhcW5iSV\OZYxxcGFibHX2[YwhcW5iaIXtZY4hWEKPQzDh[pRmeiB{NDDodpMhemWuYYTpeoUhfG9iY3;ueJJwdA>? MYqxO|U1QDR7Nx?=
Huh7 replicon cells M17BVmZ2dmO2aX;uJIF{e2G7 MXXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR3YhcW6oZXP0[YQhcHWvYX6gTJVpPyC{ZYDsbYNwdiClZXzsd{B1emWjdHXkJJdqfGhiZIL1[{1qdmS3Y3XkJIh2dWGwIGDCUWMhe3WyZYLuZZRidnS|IHHzd4V{e2WmIHHzJJZqemGuIHzleoVteyCkeTDseYNq\mW{YYPlJIF{e2G7 MkXuNVc2PDh2OUe=

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In vivo In wild-type mice, Resiquimod (50 nmol, i.p.) induces increased serum concentrations of IFN-alpha, TNF-alpha and IL-12, while neither TLR7-deficient mice nor MyD88-deficient mice show an increase in these cytokines. [1] In a murine model of allergic asthma, Resiquimod (i.n., 20 μg/mouse) reduces allergen induced airway reactivity and inflammation via reduction in Nrf2 signaling. [4]


Animal Research:


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  • Animal Models: Wild-type mice, TLR7-deficient mice, and MyD88-deficient mice
  • Dosages: 50 nmol
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 63 mg/mL (200.39 mM)
Ethanol 21 mg/mL warmed (66.79 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 314.38


CAS No. 144875-48-9
Storage powder
in solvent
Synonyms R-848
Smiles CCOCC1=NC2=C([N]1CC(C)(C)O)C3=C(C=CC=C3)N=C2N

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID