Catalog No.S8133 Synonyms: R-848
Molecular Weight(MW): 314.38
Resiquimod is an immune response modifier that acts as a potent TLR 7/8 agonist. Phase 2.
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|Description||Resiquimod is an immune response modifier that acts as a potent TLR 7/8 agonist. Phase 2.|
Resiquimod activates immune cells and induces proliferation of wild-type splenocytes via the Toll-like receptor 7 (TLR7)-MyD88-dependent signaling pathway.  Resiquimod also modulates dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses.  Resiquimod induces the differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells, and may improve cancer immunotherapy by reducing immunosuppressive MDSCs. 
|In vivo||In wild-type mice, Resiquimod (50 nmol, i.p.) induces increased serum concentrations of IFN-alpha, TNF-alpha and IL-12, while neither TLR7-deficient mice nor MyD88-deficient mice show an increase in these cytokines.  In a murine model of allergic asthma, Resiquimod (i.n., 20 μg/mouse) reduces allergen induced airway reactivity and inflammation via reduction in Nrf2 signaling. |
|In vitro||DMSO||63 mg/mL (200.39 mM)|
|Ethanol||21 mg/mL warmed (66.79 mM)|
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