Catalog No.S8133 Synonyms: R-848

Resiquimod Chemical Structure

Molecular Weight(MW): 314.38

Resiquimod is an immune response modifier that acts as a potent TLR 7/8 agonist. Phase 2.

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Biological Activity

Description Resiquimod is an immune response modifier that acts as a potent TLR 7/8 agonist. Phase 2.
TLR7 [1] TLR8 [1]
In vitro

Resiquimod activates immune cells and induces proliferation of wild-type splenocytes via the Toll-like receptor 7 (TLR7)-MyD88-dependent signaling pathway. [1] Resiquimod also modulates dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses. [2] Resiquimod induces the differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells, and may improve cancer immunotherapy by reducing immunosuppressive MDSCs. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 cells MVjGeY5kfGmxbjDhd5NigQ>? M2rMSWFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gWGxTPyCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGOxZYjwdoV{e2mwZzDwUolHfHl{LWPFRXAhemWyb4L0[ZIh[nlicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1yLkK2NFEh|ryP NF\6dpAzODJ|MkiyOC=>
HEK293 cells NGjKNFRHfW6ldHnvckBie3OjeR?= M2i0UVI1KGh? NWHyVm57SWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBVVFJvNzDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCVRVHQJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9NU42KM7:TR?= NV:1PVJXOjR|OEO0O|U>
human PBMC NICze4RHfW6ldHnvckBie3OjeR?= NUXMfmE1OjRiaB?= M1zHOWlv[3KnYYPlJIlvKEmITnHsdIhiKGyndnXsJIlvKGi3bXHuJHBDVUNiYX\0[ZIhOjRiaILzJJJmdGG2aY\lJJRwKGOxboTyc4w> MXyxO|U1QDR7Nx?=
human PBMC MXrGeY5kfGmxbjDhd5NigQ>? M3T3VFExODBibl2= MlPZNVghcA>? M2mxO2lv\HWldHnvckBw\iC2eYDlJFEhUU[QIIPlZ5JmfGmxbjDpckBpfW2jbjDQRm1EKGG2IEGwNFAhdk1iYX\0[ZIhOThiaILzJIJ6KEWOSWPB M1i5PVIxOjN{OEK0
Huh7 replicon cells NVrPPJljTnWwY4Tpc44h[XO|YYm= NXvlRW8zSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOYIHnu[oVkfGWmIHj1cYFvKEi3aEegdoVxdGmlb36gZ4VtdHNidILlZZRm\CC5aYToJIRzfWdvaX7keYNm\CCqdX3hckBRSk2FIIP1dIVzdmG2YX70d{Bie3Onc4Pl[EBieyC4aYLhcEBt\X[nbIOgZpkhdHWlaX\ldoF{\SCjc4PhfS=> MmjCNVc2PDh2OUe=

... Click to View More Cell Line Experimental Data

In vivo In wild-type mice, Resiquimod (50 nmol, i.p.) induces increased serum concentrations of IFN-alpha, TNF-alpha and IL-12, while neither TLR7-deficient mice nor MyD88-deficient mice show an increase in these cytokines. [1] In a murine model of allergic asthma, Resiquimod (i.n., 20 μg/mouse) reduces allergen induced airway reactivity and inflammation via reduction in Nrf2 signaling. [4]


Animal Research:


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  • Animal Models: Wild-type mice, TLR7-deficient mice, and MyD88-deficient mice
  • Formulation: saline
  • Dosages: 50 nmol
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 63 mg/mL (200.39 mM)
Ethanol 21 mg/mL warmed (66.79 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 314.38


CAS No. 144875-48-9
Storage powder
in solvent
Synonyms R-848

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01204684 Active not recruiting Glioma|Anaplastic Astrocytoma|Anaplastic Astro-oligodendroglioma|Glioblastoma Jonsson Comprehensive Cancer Center October 8 2010 Phase 2
NCT02126579 Recruiting Melanoma|Metastatic Melanoma|Mucosal Melanoma Craig L Slingluff Jr|University of Virginia April 2014 Phase 1|Phase 2
NCT01737580 Completed Influenza Vaccination in Seniors University of British Columbia April 2013 Phase 1
NCT01808950 Terminated Nodular Basal Cell Carcinoma Spirig Pharma Ltd. February 2013 Phase 1|Phase 2
NCT01748747 Completed Recurrent Melanoma|Stage IIA Melanoma|Stage IIB Melanoma|Stage IIC Melanoma|Stage IIIA Melanoma|Stage IIIB Melanoma|Stage IIIC Melanoma|Stage IV Melanoma Mayo Clinic|National Cancer Institute (NCI) October 2012 Early Phase 1
NCT01583816 Completed Actinic Keratosis Spirig Pharma Ltd. May 2012 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID