Home Biosimilar Antibodies Immunology & Inflammation Interleukins Clazakizumab (Anti-IL-6 / IFNb2)
For research use only. Not for use in humans.

Clazakizumab (Anti-IL-6 / IFNb2)

Clazakizumab (Anti-IL-6 / IFNb2) is a monoclonal antibody targeting the IL-6 (interleukin-6). It inhibitsg the cytokine response to SARS-CoV-2 in COVID-19 and can be used for the research of psoriatic arthritis (PsA) and renal antibody-mediated rejection. MW :145.24 KD.

Clazakizumab (Anti-IL-6 / IFNb2)

1 Citation

The Nobel Prize

17 Nobel Prize winners have used Selleck products

Shimon Sakaguchi

Nature Communications 2025,16, Article number:1325

David Baker

Dev Cell 2023, 58(20):2163-2180.e9.

David Julius

Cell 2017, 185-198.e16

Michael Houghton

Cell Chem Biol, 2020, 27(7):780-792.e5

Charles M. Rice

Cell 2018, 172(3):423-438.e25

Quality Control

Batch: A260901 Purity: 99% Protein concentration: 5.330mg/ml Endotoxin Level: ＜1EU/mg
99

Specificity

Name Citation IL-6 IL-1 IL-8 IL-12 IL-10 IL-13 IL-2 Others
SKF-86002 1
JTE-607 Dihydrochloride 2 TNF-alpha
A-740003 2 rat P2X7 receptor,human P2X7 receptor
Apilimod mesylate 6 PIKfyve
MD2-TLR4-IN-1 2 TLR4,TNF-α
Danirixin (GSK1325756) 2 CXCR2
Resatorvid (TAK-242) 65 TLR4,NO,TNF-α
Apilimod (STA-5326) 19 PIKfyve
LMT-28 1
Atractylodin 0 NAAA
Triolein 0 ROS,MMP-1
Ac-YVAD-cmk 5
Diethyl phosphate 1
RCM-1 5 STAT6,FOXM1,β-catenin
Stylopine 0 COX-2,TNF-α,NO
Myrislignan 1 NF-κB,COX-2,iNOS
NE 52-QQ57 2 iNOS,TNF-α,PGE2
PKR-IN-C16 9 PKR
(3R,8S)-Falcarindiol 3 STAT,ERK,JNK
Gardenoside 1 P2X7 Receptor,P2X3 receptor,NF-κB
T-5224 23 c-Jun,c-Fos/AP-1,Adamts-5
IQ 3 1 TNF-α,JNK3,JNK1
Isuzinaxib (APX-115 free base) 2 TNFα,MCP-1/CCL2,NOX2
AUDA 1 p38,Smad3,TGF-β
SAR-20347 1 IFN-α,TYK2,JAK1
SU 5201 0
Madecassic acid 3 TNF-α,COX-2,iNOS
Homoplantaginin 1 NF-κB,IKKβ,TNF-α
2',5'-Dihydroxyacetophenone 1 NF-κB,ERK1/2,iNOS
Forsythoside B 0 NF-κB,TNF-alpha,IκB
Mulberroside A 0 NF-κB,Caspase-1,NALP3
Chelidonic acid 0 glutamate decarboxylase,Caspase-1,NF-κB
4-Methylesculetin 2 MPO
Muscone 4 TNF-α,NLRP3 inflammasome,NF-κB
Ossirene (AS101) 16
Methylthiouracil 1 ERK1/2,NF-κB,TNF-α
Expand to Check More
1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Clazakizumab (Anti-IL-6 / IFNb2) is a monoclonal antibody targeting the IL-6 (interleukin-6). It inhibitsg the cytokine response to SARS-CoV-2 in COVID-19 and can be used for the research of psoriatic arthritis (PsA) and renal antibody-mediated rejection. MW :145.24 KD.
References

Product Details

CAS No. 1236278-28-6
Molecular Weight 145.24
Isotype Human IgG1
Source CHO
Purification AKTA
Sterility 0.2 μM filtered
Formulation 100 mM Pro-Ac, 20mM Arg, pH5.0
Storage
(From the date of receipt)		 Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05485961 RECRUITING Drug: CSL300|Drug: Placebo End Stage Kidney Disease CSL Behring 2022-10-21 PHASE2; PHASE3
NCT05305066 RECRUITING Drug: TNFi|Drug: Anti-IL6|Drug: JAKi Rheumatoid Arthritis Marie Hudson, MD 2023-02-01
NCT07619820 RECRUITING End Stage Kidney Disease (ESKD) CSL Behring 2026-06-17 PHASE1
NCT07783802 NOT_YET_RECRUITING Drug: Clazakizumab|Drug: Placebo Atherosclerosis; Cardiovascular Disease; Obesity; Hypertension; Diabetes Mellitus, Type 2; Renal Insufficiency, Chronic Eli Lilly and Company 2026-09 PHASE2
NCT05679570 COMPLETED Drug: Satralizumab (Genetical Recombination) Pulmonary Arterial Hypertension International University of Health and Welfare 2022-07-12 PHASE2
NCT05727384 COMPLETED Drug: Clazakizumab|Drug: Placebo Inflammation; Frailty Anne B. Newman 2023-08-01 PHASE2

(data from https://clinicaltrials.gov, updated on 2026-08-11)

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