Home Biosimilar Antibodies Immunology & Inflammation Interleukins Melrilimab (Anti-IL-1RL1 / ST2 / IL-33R)
For research use only. Not for use in humans.

Melrilimab (Anti-IL-1RL1 / ST2 / IL-33R)

Synonyms: IL33R,T1

Melrilimab (anti-IL-1RL1/ ST2 / IL-33R) is an anti-ST2 (IL-1RL) monoclonal antibody targeting the IL-33 receptor. Melrilimab has the potential to be used in asthma research. MW: 145.2 KD.

Melrilimab (Anti-IL-1RL1 / ST2 / IL-33R)

Quality Control

Batch: A296201 Purity: 99% Protein concentration: 8.48mg/ml Endotoxin Level: ＜1EU/mg
99

Specificity

Name Citation IL-6 IL-1 IL-8 IL-12 IL-10 IL-13 IL-2 Others
SKF-86002 1
JTE-607 Dihydrochloride 2 TNF-alpha
A-740003 2 rat P2X7 receptor,human P2X7 receptor
Apilimod mesylate 6 PIKfyve
MD2-TLR4-IN-1 2 TLR4,TNF-α
Danirixin (GSK1325756) 2 CXCR2
Resatorvid (TAK-242) 65 TLR4,NO,TNF-α
Apilimod (STA-5326) 19 PIKfyve
LMT-28 1
Atractylodin 0 NAAA
Triolein 0 ROS,MMP-1
Ac-YVAD-cmk 5
Diethyl phosphate 1
RCM-1 5 STAT6,FOXM1,β-catenin
Stylopine 0 COX-2,TNF-α,NO
Myrislignan 1 NF-κB,COX-2,iNOS
NE 52-QQ57 2 iNOS,TNF-α,PGE2
PKR-IN-C16 9 PKR
(3R,8S)-Falcarindiol 3 STAT,ERK,JNK
Gardenoside 1 P2X7 Receptor,P2X3 receptor,NF-κB
T-5224 23 c-Jun,c-Fos/AP-1,Adamts-5
IQ 3 1 TNF-α,JNK3,JNK1
Isuzinaxib (APX-115 free base) 2 TNFα,MCP-1/CCL2,NOX2
AUDA 1 p38,Smad3,TGF-β
SAR-20347 1 IFN-α,TYK2,JAK1
SU 5201 0
Madecassic acid 3 TNF-α,COX-2,iNOS
Homoplantaginin 1 NF-κB,IKKβ,TNF-α
2',5'-Dihydroxyacetophenone 1 NF-κB,ERK1/2,iNOS
Forsythoside B 0 NF-κB,TNF-alpha,IκB
Mulberroside A 0 NF-κB,Caspase-1,NALP3
Chelidonic acid 0 glutamate decarboxylase,Caspase-1,NF-κB
4-Methylesculetin 2 MPO
Muscone 4 TNF-α,NLRP3 inflammasome,NF-κB
Ossirene (AS101) 16
Methylthiouracil 1 ERK1/2,NF-κB,TNF-α
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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Melrilimab (anti-IL-1RL1/ ST2 / IL-33R) is an anti-ST2 (IL-1RL) monoclonal antibody targeting the IL-33 receptor. Melrilimab has the potential to be used in asthma research. MW: 145.2 KD.
References

Product Details

CAS No. 2222865-46-3
Molecular Weight 145.2
Isotype Human IgG2SA
Source CHO
Purification AKTA
Sterility 0.2 μM filtered
Formulation 100 mM Pro-Ac, 20mM Arg, pH5.0
Storage
(From the date of receipt)		 Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05683873 RECRUITING Ischemic Stroke Centre Hospitalier Universitaire Dijon 2023-02-13
NCT05661201 RECRUITING Drug: NEROFE|Drug: Doxorubicin Solid Tumor; KRAS Mutation-Related Tumors Georgetown University 2023-04-12 PHASE1
NCT07412795 NOT_YET_RECRUITING Stable Angina; Periodontitis Ondokuz Mayıs University 2026-02-20
NCT07436208 COMPLETED HDM-Induced Allergic Rhinitis Zagazig University 2025-02-01 PHASE1
NCT06647667 COMPLETED Heart Failure Cairo University 2022-09-15
NCT04366349 COMPLETED Healthy Volunteers; Asthma GlaxoSmithKline 2020-07-21 PHASE1

(data from https://clinicaltrials.gov, updated on 2025-01-28)

Tech Support

Handling Instructions

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