Home Immunology & Inflammation NADPH-oxidase inhibitor - CCR inhibitor - Interleukins inhibitor - TNF-alpha inhibitor Isuzinaxib (APX-115 free base) For research use only.

Isuzinaxib (APX-115 free base)

Synonyms: Ewha-18278 free base

Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.

Isuzinaxib (APX-115 free base) Chemical Structure

Isuzinaxib (APX-115 free base) Chemical Structure

CAS: 1270084-92-8

Purity & Quality Control

Batch: Purity: 99.05%
99.05

Isuzinaxib (APX-115 free base) Related Products

Choose Selective NADPH-oxidase Inhibitors

Biological Activity

Description Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.
Targets
MCP-1/CCL2 [2] IL-6 [1] TNFα [2] NOX2 [1]
(Cell-free assay)		 NOX4 [1]
(Cell-free assay)		 Click to View More Targets
0.57 μM(Ki) 0.63 μM(Ki)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04534439 Completed
Diabetic Nephropathies|Diabetes Mellitus Type 2|Nephropathy Diabetic
Aptabio Therapeutics Inc.
 August 24 2020 Phase 2

Chemical Information & Solubility

Molecular Weight 279.34 Formula

C17H17N3O
CAS No. 1270084-92-8 SDF --
Smiles CCCC1=C(NN(C1=O)C2=CC=CC=N2)C3=CC=CC=C3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 56 mg/mL ( (200.47 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 56 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Isuzinaxib (APX-115 free base) | Isuzinaxib (APX-115 free base) supplier | purchase Isuzinaxib (APX-115 free base) | Isuzinaxib (APX-115 free base) cost | Isuzinaxib (APX-115 free base) manufacturer | order Isuzinaxib (APX-115 free base) | Isuzinaxib (APX-115 free base) distributor