Home Biosimilar Antibodies Immunology & Inflammation Interleukins Spesolimab (Anti-IL-1RL2 / IL-36R)
For research use only. Not for use in humans.

Spesolimab (Anti-IL-1RL2 / IL-36R)

Synonyms: IL-1RL2， IL-36 receptor

Spesolimab (Anti-IL-1RL2 / IL-36R) is an humanized antagonistic monoclonal antibody targeting IL-36 receptor. It can be used for treatment of palmoplantar pustulosis (PPP) and generalized pustular psoriasis (GPP). MW : 145.5 KD.

Spesolimab (Anti-IL-1RL2 / IL-36R)

Quality Control

Batch: A244201 Purity: 99% Protein concentration: 4.09mg/ml Endotoxin Level: ＜1EU/mg
99

Specificity

Name Citation IL-6 IL-1 IL-8 IL-12 IL-10 IL-13 IL-2 Others
SKF-86002 1
JTE-607 Dihydrochloride 2 TNF-alpha
A-740003 2 rat P2X7 receptor,human P2X7 receptor
Apilimod mesylate 6 PIKfyve
MD2-TLR4-IN-1 2 TLR4,TNF-α
Danirixin (GSK1325756) 2 CXCR2
Resatorvid (TAK-242) 65 TLR4,NO,TNF-α
Apilimod (STA-5326) 19 PIKfyve
LMT-28 1
Atractylodin 0 NAAA
Triolein 0 ROS,MMP-1
Ac-YVAD-cmk 5
Diethyl phosphate 1
RCM-1 5 STAT6,FOXM1,β-catenin
Stylopine 0 COX-2,TNF-α,NO
Myrislignan 1 NF-κB,COX-2,iNOS
NE 52-QQ57 2 iNOS,TNF-α,PGE2
PKR-IN-C16 9 PKR
(3R,8S)-Falcarindiol 3 STAT,ERK,JNK
Gardenoside 1 P2X7 Receptor,P2X3 receptor,NF-κB
T-5224 23 c-Jun,c-Fos/AP-1,Adamts-5
IQ 3 1 TNF-α,JNK3,JNK1
Isuzinaxib (APX-115 free base) 2 TNFα,MCP-1/CCL2,NOX2
AUDA 1 p38,Smad3,TGF-β
SAR-20347 1 IFN-α,TYK2,JAK1
SU 5201 0
Madecassic acid 3 TNF-α,COX-2,iNOS
Homoplantaginin 1 NF-κB,IKKβ,TNF-α
2',5'-Dihydroxyacetophenone 1 NF-κB,ERK1/2,iNOS
Forsythoside B 0 NF-κB,TNF-alpha,IκB
Mulberroside A 0 NF-κB,Caspase-1,NALP3
Chelidonic acid 0 glutamate decarboxylase,Caspase-1,NF-κB
4-Methylesculetin 2 MPO
Muscone 4 TNF-α,NLRP3 inflammasome,NF-κB
Ossirene (AS101) 16
Methylthiouracil 1 ERK1/2,NF-κB,TNF-α
Expand to Check More
1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Spesolimab (Anti-IL-1RL2 / IL-36R) is an humanized antagonistic monoclonal antibody targeting IL-36 receptor. It can be used for treatment of palmoplantar pustulosis (PPP) and generalized pustular psoriasis (GPP). MW : 145.5 KD.

Product Details

CAS No. 2097104-58-8
Molecular Weight 145.5 kDa
Isotype Human IgG1
Source CHO
Purification AKTA
Sterility 0.2 μM filtered
Formulation 100 mM Pro-Ac, 20mM Arg, pH5.0
Storage
(From the date of receipt)		 Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT06624670 RECRUITING Drug: Spesolimab|Drug: Placebo matching to spesolimab|Drug: Pyoderma Gangrenosum LEO Pharma 2025-02-05 PHASE3
NCT03886246 ACTIVE_NOT_RECRUITING Drug: Spesolimab|Drug: Spesolimab Generalized Pustular Psoriasis LEO Pharma 2019-05-29 PHASE2
NCT07449156 NOT_YET_RECRUITING Drug: HB0043|Drug: Placebo Acne Vulgaris Shanghai Huaota Biopharmaceutical Co., Ltd. 2026-03-27 PHASE1; PHASE2
NCT06013969 ACTIVE_NOT_RECRUITING Drug: Spesolimab Generalized Pustular Psoriasis LEO Pharma 2023-10-22 PHASE4
NCT06895499 RECRUITING Drug: HB0043|Drug: HB0043|Drug: HB0043 Hidradenitis Suppurativa Shanghai Huaota Biopharmaceutical Co., Ltd. 2025-03-19 PHASE1; PHASE2
NCT06241573 TERMINATED Drug: Spesolimab|Drug: Placebo Hidradenitis Suppurativa (HS) Boehringer Ingelheim 2024-05-08 PHASE2; PHASE3

(data from https://clinicaltrials.gov, updated on 2026-09-02)

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Handling Instructions

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