Home Immunology & Inflammation Interleukins inhibitor - JNK inhibitor - NF-κB inhibitor - TNF-alpha inhibitor IQ 3 For research use only.

IQ 3

IQ 3 is a specific c-Jun N-terminal kinase (JNK) inhibitor with Kd of 66 nM, 240 nM and 290 nM for JNK3, JNK1 and JNK2, respectively. IQ 3 inhibits LPS-induced NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM. IQ 3 also inhibits TNF-α and IL-6 production in vitro.

IQ 3 Chemical Structure

IQ 3 Chemical Structure

CAS: 312538-03-7

Purity & Quality Control

Batch: S078101 DMSO] 5 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.28%
99.28

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Biological Activity

Description IQ 3 is a specific c-Jun N-terminal kinase (JNK) inhibitor with Kd of 66 nM, 240 nM and 290 nM for JNK3, JNK1 and JNK2, respectively. IQ 3 inhibits LPS-induced NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM. IQ 3 also inhibits TNF-α and IL-6 production in vitro.
Targets
IL-6 [1] TNF-α [1] JNK3 [1]
(Cell-free assay)		 JNK1 [1]
(Cell-free assay)		 JNK2 [1]
(Cell-free assay)		 Click to View More Targets
66 nM(Kd) 240 nM(Kd) 290 nM(Kd)

Chemical Information & Solubility

Molecular Weight 341.32 Formula

C20H11N3O3
CAS No. 312538-03-7 SDF --
Smiles C1=CC=C2C(=C1)C3=NC4=CC=CC=C4N=C3C2=NOC(=O)C5=CC=CO5
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 5 mg/mL ( (14.64 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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