Home Immunology & Inflammation Interleukins inhibitor - JNK inhibitor - NF-κB inhibitor - TNF-alpha inhibitor IQ 3

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IQ 3 Interleukins inhibitor

Cat.No.S0781

IQ 3 is a specific c-Jun N-terminal kinase (JNK) inhibitor with Kd of 66 nM, 240 nM and 290 nM for JNK3, JNK1 and JNK2, respectively. This compound inhibits LPS-induced NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM. It also inhibits TNF-α and IL-6 production in vitro.
IQ 3 Interleukins inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 341.32

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S078101 DMSO]5 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.28%
99.28

Chemical Information, Storage & Stability

Molecular Weight 341.32 Formula

C20H11N3O3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 312538-03-7 -- Storage of Stock Solutions

Synonyms N/A Smiles C1=CC=C2C(=C1)C3=NC4=CC=CC=C4N=C3C2=NOC(=O)C5=CC=CO5

Solubility

In vitro
Batch:

DMSO : 5 mg/mL (14.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
IL-6 [1]
TNF-α [1]
JNK3 [1]
(Cell-free assay)
66 nM(Kd)
JNK1 [1]
(Cell-free assay)
240 nM(Kd)
JNK2 [1]
(Cell-free assay)
290 nM(Kd)
NF-κB/AP1 [1]
(in THP1-Blue cells)
1.4 μM
References

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