IQ 3

Catalog No.S0781

For research use only.

IQ 3 is a specific c-Jun N-terminal kinase (JNK) inhibitor with Kd of 66 nM, 240 nM and 290 nM for JNK3, JNK1 and JNK2, respectively. IQ 3 inhibits LPS-induced NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM. IQ 3 also inhibits TNF-α and IL-6 production in vitro.

IQ 3 Chemical Structure

CAS No. 312538-03-7

Purity & Quality Control

Choose Selective Interleukins Inhibitors

Biological Activity

Description IQ 3 is a specific c-Jun N-terminal kinase (JNK) inhibitor with Kd of 66 nM, 240 nM and 290 nM for JNK3, JNK1 and JNK2, respectively. IQ 3 inhibits LPS-induced NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM. IQ 3 also inhibits TNF-α and IL-6 production in vitro.
Targets
IL-6 [1]
()
TNF-α [1]
()
JNK3 [1]
(Cell-free assay)
JNK1 [1]
(Cell-free assay)
JNK2 [1]
(Cell-free assay)
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66 nM(Kd) 240 nM(Kd) 290 nM(Kd)

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 10 mg/mL warmed
(29.29 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 341.32
Formula

C20H11N3O3

CAS No. 312538-03-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C2C(=C1)C3=NC4=CC=CC=C4N=C3C2=NOC(=O)C5=CC=CO5

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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