Histamine Phosphate
Catalog No.S4117
Molecular Weight(MW): 307.14
Histamine acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.
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Biological Activity
| Description | Histamine acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors. | ||
|---|---|---|---|
| Features | Histamine phosphate is indicated as a diagnostic aid for evaluation of gastric acid secretory function. | ||
| Targets |
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| In vitro |
Histamine (10 μM) gives a larger inositol monophosphate accumulation in bovine adrenal chromaffin cells. Histamine (10 μM) stimulates the level of radioactivity into the InsP3-containing fraction in bovine adrenal chromaffin cells. Histamine (100 μM) stimulates incorporation into the InsP3-containing eluate in a less extent than for angiotensin I1 and bradykinin. [1] |
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| In vivo | Histamine phosphate (0.025 mg/kg) produces a mean increase in basilar blood flow of 145% of control in dogs. Histamine phosphate produces considerable increases in basilar blood flow as well as a decrease in femoral arterial blood pressure in dogs when injected intravenously and measured with an electromagnetic flow transducer. [2] Histamine phosphate (4 μg/kg) causes lymph flow to increase from 6.0 to 27.0 (SEM) ml/h in unanesthetized sheep. Histamine phosphate (4 μg/kg) also causes increases in lung water, pulmonary vascular resistance, arterial PCO2, pH, and hematocrit, and decreases in cardiac output and arterial PO2 in unanesthetized sheep. [3] Histamine phosphate (8.3 mg/kg/min) causes no significant change in pulmonary lymph flow (QL) or protein concentration (CL) in anesthetized open-chested dogs, however, both are increased after alloxan. Histamine phosphate (8.3 mg/kg/min) also causes no significant change in the pulmonary capillary membrane filtration coefficient (Kf) and the maximum capillary pressure (PCcritical) in anesthetized open-chested dogs. [4] Histamine phosphate (50 mg/kg) produces a pronounced rise in acid secretion but the output of pepsin remained unchanged in the unanaesthetized intact rat. Histamine phosphate (50 mg/kg) produces maximal stimulation of gastric acid secretion and is free from toxic effects in the unanaesthetized intact rat. [5] |
Protocol
Solubility (25°C)
| In vitro | Water | 42 mg/mL (136.74 mM) |
|---|---|---|
| DMSO | Insoluble | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 307.14 |
|---|---|
| Formula | C5H9N.2H3O4P |
| CAS No. | 51-74-1 |
| Storage | powder |
| in solvent | |
| Synonyms | N/A |
Bio Calculators
Molarity Calculator
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Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT03587220 | Recruiting | Capsaicin|Ultaviolet B Light Burn|Neuropathic Pain|Lidocaine | Aalborg University | August 1 2018 | Not Applicable |
| NCT03590912 | Not yet recruiting | Otitis Media With Effusion | Lumbini Medical College | August 2018 | Phase 4 |
| NCT03576053 | Recruiting | Itch|Thermal Stimulation|Histamine|Cowhage|Serotonine | Aalborg University | July 1 2018 | Not Applicable |
| NCT03050866 | Recruiting | Circulating Tumor Cell|Metastatic Prostate Cancer | Erasmus Medical Center|Sanofi | February 21 2017 | Phase 2 |
| NCT02882217 | Completed | Asthma | EURRUS Biotech GmbH | August 2016 | Phase 1 |
| NCT02889159 | Recruiting | Photoaged Skin|Normal Skin | University of Michigan | June 6 2016 | Not Applicable |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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