For research use only.
CAS No. 51-74-1
Histamine acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.
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Choose Selective Histamine Receptor Inhibitors
|Description||Histamine acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.|
|Features||Histamine phosphate is indicated as a diagnostic aid for evaluation of gastric acid secretory function.|
Histamine (10 μM) gives a larger inositol monophosphate accumulation in bovine adrenal chromaffin cells. Histamine (10 μM) stimulates the level of radioactivity into the InsP3-containing fraction in bovine adrenal chromaffin cells. Histamine (100 μM) stimulates incorporation into the InsP3-containing eluate in a less extent than for angiotensin I1 and bradykinin. 
|In vivo||Histamine phosphate (0.025 mg/kg) produces a mean increase in basilar blood flow of 145% of control in dogs. Histamine phosphate produces considerable increases in basilar blood flow as well as a decrease in femoral arterial blood pressure in dogs when injected intravenously and measured with an electromagnetic flow transducer.  Histamine phosphate (4 μg/kg) causes lymph flow to increase from 6.0 to 27.0 (SEM) ml/h in unanesthetized sheep. Histamine phosphate (4 μg/kg) also causes increases in lung water, pulmonary vascular resistance, arterial PCO2, pH, and hematocrit, and decreases in cardiac output and arterial PO2 in unanesthetized sheep.  Histamine phosphate (8.3 mg/kg/min) causes no significant change in pulmonary lymph flow (QL) or protein concentration (CL) in anesthetized open-chested dogs, however, both are increased after alloxan. Histamine phosphate (8.3 mg/kg/min) also causes no significant change in the pulmonary capillary membrane filtration coefficient (Kf) and the maximum capillary pressure (PCcritical) in anesthetized open-chested dogs.  Histamine phosphate (50 mg/kg) produces a pronounced rise in acid secretion but the output of pepsin remained unchanged in the unanaesthetized intact rat. Histamine phosphate (50 mg/kg) produces maximal stimulation of gastric acid secretion and is free from toxic effects in the unanaesthetized intact rat. |
|In vitro||Water||42 mg/mL (136.74 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04534036||Recruiting||Dietary Supplement: PDS-08|Other: Placebo||Constipation|Signs and Symptoms|Digestive Signs and Symptoms|Infrequent or Difficult Evacuation||Seed Health|Curebase Inc.||August 13 2020||Not Applicable|
|NCT04439955||Recruiting||Drug: CBD||Chronic Spontaneous Urticaria||Stero Biotechs Ltd.||February 1 2020||Phase 2|
|NCT04286542||Recruiting||Diagnostic Test: Cold dry air||Hyperactivity|Allergic Rhinitis Due to House Dust Mite|Chronic Rhinosinusitis With Nasal Polyps||Universitaire Ziekenhuizen Leuven||January 20 2020||Not Applicable|
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