Histamine Phosphate

Synonyms: Histamine diphosphate

Histamine(Histamine diphosphate) acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.

Histamine Phosphate Chemical Structure

Histamine Phosphate Chemical Structure

CAS: 51-74-1

Purity & Quality Control

Batch: Purity: 99.99%
99.99

Histamine Phosphate Related Products

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Biological Activity

Description Histamine(Histamine diphosphate) acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.
Features Histamine phosphate is indicated as a diagnostic aid for evaluation of gastric acid secretory function.
Targets
Histamine H1 receptor [1] Histamine H2 receptor [1]
In vitro
In vitro

Histamine (10 μM) gives a larger inositol monophosphate accumulation in bovine adrenal chromaffin cells. Histamine (10 μM) stimulates the level of radioactivity into the InsP3-containing fraction in bovine adrenal chromaffin cells. Histamine (100 μM) stimulates incorporation into the InsP3-containing eluate in a less extent than for angiotensin I1 and bradykinin. [1]

In Vivo
In vivo

Histamine phosphate (0.025 mg/kg) produces a mean increase in basilar blood flow of 145% of control in dogs. Histamine phosphate produces considerable increases in basilar blood flow as well as a decrease in femoral arterial blood pressure in dogs when injected intravenously and measured with an electromagnetic flow transducer. [2] Histamine phosphate (4 μg/kg) causes lymph flow to increase from 6.0 to 27.0 (SEM) ml/h in unanesthetized sheep. Histamine phosphate (4 μg/kg) also causes increases in lung water, pulmonary vascular resistance, arterial PCO2, pH, and hematocrit, and decreases in cardiac output and arterial PO2 in unanesthetized sheep. [3] Histamine phosphate (8.3 mg/kg/min) causes no significant change in pulmonary lymph flow (QL) or protein concentration (CL) in anesthetized open-chested dogs, however, both are increased after alloxan. Histamine phosphate (8.3 mg/kg/min) also causes no significant change in the pulmonary capillary membrane filtration coefficient (Kf) and the maximum capillary pressure (PCcritical) in anesthetized open-chested dogs. [4] Histamine phosphate (50 mg/kg) produces a pronounced rise in acid secretion but the output of pepsin remained unchanged in the unanaesthetized intact rat. Histamine phosphate (50 mg/kg) produces maximal stimulation of gastric acid secretion and is free from toxic effects in the unanaesthetized intact rat. [5]

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05216133 Enrolling by invitation
Airway Disease|Barrett Esophagus|Gastroesophageal Reflux Disease
NYU Langone Health|National Institute for Occupational Safety and Health (NIOSH/CDC)
March 22 2023 --
NCT05701826 Completed
Skeletal Muscle Relaxation
Fujian Shengdi Pharmaceutical Co. Ltd.
February 15 2023 Phase 1
NCT05676346 Completed
Lower Urinary Tract Symptoms|Histamine Intolerance
Complexo Hospitalario Universitario de A Coruña
October 11 2022 --
NCT05832528 Recruiting
Functional Gastrointestinal Disorders
Universitaire Ziekenhuizen KU Leuven
October 3 2022 Not Applicable

Chemical Information & Solubility

Molecular Weight 307.14 Formula

C5H9N.2H3O4P

CAS No. 51-74-1 SDF Download Histamine Phosphate SDF
Smiles C1=C(NC=N1)CCN.OP(=O)(O)O.OP(=O)(O)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 61 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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