Histamine Phosphate
Catalog No.S4117
Molecular Weight(MW): 307.14
Histamine acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.
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Biological Activity
| Description | Histamine acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors. | ||
|---|---|---|---|
| Features | Histamine phosphate is indicated as a diagnostic aid for evaluation of gastric acid secretory function. | ||
| Targets |
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| In vitro |
Histamine (10 μM) gives a larger inositol monophosphate accumulation in bovine adrenal chromaffin cells. Histamine (10 μM) stimulates the level of radioactivity into the InsP3-containing fraction in bovine adrenal chromaffin cells. Histamine (100 μM) stimulates incorporation into the InsP3-containing eluate in a less extent than for angiotensin I1 and bradykinin. [1] |
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| In vivo | Histamine phosphate (0.025 mg/kg) produces a mean increase in basilar blood flow of 145% of control in dogs. Histamine phosphate produces considerable increases in basilar blood flow as well as a decrease in femoral arterial blood pressure in dogs when injected intravenously and measured with an electromagnetic flow transducer. [2] Histamine phosphate (4 μg/kg) causes lymph flow to increase from 6.0 to 27.0 (SEM) ml/h in unanesthetized sheep. Histamine phosphate (4 μg/kg) also causes increases in lung water, pulmonary vascular resistance, arterial PCO2, pH, and hematocrit, and decreases in cardiac output and arterial PO2 in unanesthetized sheep. [3] Histamine phosphate (8.3 mg/kg/min) causes no significant change in pulmonary lymph flow (QL) or protein concentration (CL) in anesthetized open-chested dogs, however, both are increased after alloxan. Histamine phosphate (8.3 mg/kg/min) also causes no significant change in the pulmonary capillary membrane filtration coefficient (Kf) and the maximum capillary pressure (PCcritical) in anesthetized open-chested dogs. [4] Histamine phosphate (50 mg/kg) produces a pronounced rise in acid secretion but the output of pepsin remained unchanged in the unanaesthetized intact rat. Histamine phosphate (50 mg/kg) produces maximal stimulation of gastric acid secretion and is free from toxic effects in the unanaesthetized intact rat. [5] |
Protocol
Solubility (25°C)
| In vitro | Water | 42 mg/mL (136.74 mM) |
|---|---|---|
| DMSO | Insoluble | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 307.14 |
|---|---|
| Formula | C5H9N.2H3O4P |
| CAS No. | 51-74-1 |
| Storage | powder |
| in solvent | |
| Synonyms | N/A |
Bio Calculators
Molarity Calculator
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Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT03805035 | Not yet recruiting | Pain | China Medical University Hospital | January 24 2019 | Not Applicable |
| NCT03805035 | Not yet recruiting | Pain | China Medical University Hospital | January 24 2019 | Not Applicable |
| NCT03587220 | Recruiting | Capsaicin|Ultaviolet B Light Burn|Neuropathic Pain|Lidocaine | Aalborg University | August 1 2018 | Not Applicable |
| NCT03590912 | Not yet recruiting | Otitis Media With Effusion | Lumbini Medical College | August 2018 | Phase 4 |
| NCT03587220 | Recruiting | Capsaicin|Ultaviolet B Light Burn|Neuropathic Pain|Lidocaine | Aalborg University | August 1 2018 | Not Applicable |
| NCT03590912 | Not yet recruiting | Otitis Media With Effusion | Lumbini Medical College | August 2018 | Phase 4 |
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