Home Neuronal Signaling Histamine Receptor agonist Histamine Phosphate For research use only.

Histamine Phosphate

Synonyms: Histamine diphosphate

Histamine(Histamine diphosphate) acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors. Histamine Phosphate can be used to induce animal models of Gastric and Intestinal Ulcers.

Histamine Phosphate Chemical Structure

Histamine Phosphate Chemical Structure

CAS No. 51-74-1

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Histamine Phosphate Related Products

Signaling Pathway

Histamine Receptor Signaling Pathways

Histamine Receptor Signaling Pathway

Biological Activity

Description Histamine(Histamine diphosphate) acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors. Histamine Phosphate can be used to induce animal models of Gastric and Intestinal Ulcers.
Features Histamine phosphate is indicated as a diagnostic aid for evaluation of gastric acid secretory function.
Targets
Histamine H1 receptor [1] Histamine H2 receptor [1]
In vitro
In vitro

Histamine (10 μM) gives a larger inositol monophosphate accumulation in bovine adrenal chromaffin cells. Histamine (10 μM) stimulates the level of radioactivity into the InsP3-containing fraction in bovine adrenal chromaffin cells. Histamine (100 μM) stimulates incorporation into the InsP3-containing eluate in a less extent than for angiotensin I1 and bradykinin. [1]
In Vivo
In vivo

Histamine phosphate (0.025 mg/kg) produces a mean increase in basilar blood flow of 145% of control in dogs. Histamine phosphate produces considerable increases in basilar blood flow as well as a decrease in femoral arterial blood pressure in dogs when injected intravenously and measured with an electromagnetic flow transducer. [2] Histamine phosphate (4 μg/kg) causes lymph flow to increase from 6.0 to 27.0 (SEM) ml/h in unanesthetized sheep. Histamine phosphate (4 μg/kg) also causes increases in lung water, pulmonary vascular resistance, arterial PCO2, pH, and hematocrit, and decreases in cardiac output and arterial PO2 in unanesthetized sheep. [3] Histamine phosphate (8.3 mg/kg/min) causes no significant change in pulmonary lymph flow (QL) or protein concentration (CL) in anesthetized open-chested dogs, however, both are increased after alloxan. Histamine phosphate (8.3 mg/kg/min) also causes no significant change in the pulmonary capillary membrane filtration coefficient (Kf) and the maximum capillary pressure (PCcritical) in anesthetized open-chested dogs. [4] Histamine phosphate (50 mg/kg) produces a pronounced rise in acid secretion but the output of pepsin remained unchanged in the unanaesthetized intact rat. Histamine phosphate (50 mg/kg) produces maximal stimulation of gastric acid secretion and is free from toxic effects in the unanaesthetized intact rat. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06281366 Recruiting
Pregnancy Complications
Hospital Universitari Vall d''Hebron Research Institute|DR Healthcare
 February 16 2024 --
NCT05216133 Enrolling by invitation
Airway Disease|Barrett Esophagus|Gastroesophageal Reflux Disease
NYU Langone Health|National Institute for Occupational Safety and Health (NIOSH/CDC)
 March 22 2023 --
NCT05701826 Completed
Skeletal Muscle Relaxation
Fujian Shengdi Pharmaceutical Co. Ltd.
 February 15 2023 Phase 1
NCT05676346 Completed
Lower Urinary Tract Symptoms|Histamine Intolerance
Complexo Hospitalario Universitario de A Coruña
 October 11 2022 --

Chemical Information & Solubility

Molecular Weight 307.14 Formula

C5H9N.2H3O4P
CAS No. 51-74-1 SDF Download Histamine Phosphate SDF
Smiles C1=C(NC=N1)CCN.OP(=O)(O)O.OP(=O)(O)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 61 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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