Home Neuronal Signaling Histamine Receptor agonist Histamine Phosphate

Histamine Phosphate

Catalog No.S4117

For research use only.

Histamine acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.

Histamine Phosphate Chemical Structure

CAS No. 51-74-1

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Biological Activity

Description Histamine acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.
Features Histamine phosphate is indicated as a diagnostic aid for evaluation of gastric acid secretory function.
Targets
Histamine H1 receptor [1] Histamine H2 receptor [1]
In vitro

Histamine (10 μM) gives a larger inositol monophosphate accumulation in bovine adrenal chromaffin cells. Histamine (10 μM) stimulates the level of radioactivity into the InsP3-containing fraction in bovine adrenal chromaffin cells. Histamine (100 μM) stimulates incorporation into the InsP3-containing eluate in a less extent than for angiotensin I1 and bradykinin. [1]
In vivo Histamine phosphate (0.025 mg/kg) produces a mean increase in basilar blood flow of 145% of control in dogs. Histamine phosphate produces considerable increases in basilar blood flow as well as a decrease in femoral arterial blood pressure in dogs when injected intravenously and measured with an electromagnetic flow transducer. [2] Histamine phosphate (4 μg/kg) causes lymph flow to increase from 6.0 to 27.0 (SEM) ml/h in unanesthetized sheep. Histamine phosphate (4 μg/kg) also causes increases in lung water, pulmonary vascular resistance, arterial PCO2, pH, and hematocrit, and decreases in cardiac output and arterial PO2 in unanesthetized sheep. [3] Histamine phosphate (8.3 mg/kg/min) causes no significant change in pulmonary lymph flow (QL) or protein concentration (CL) in anesthetized open-chested dogs, however, both are increased after alloxan. Histamine phosphate (8.3 mg/kg/min) also causes no significant change in the pulmonary capillary membrane filtration coefficient (Kf) and the maximum capillary pressure (PCcritical) in anesthetized open-chested dogs. [4] Histamine phosphate (50 mg/kg) produces a pronounced rise in acid secretion but the output of pepsin remained unchanged in the unanaesthetized intact rat. Histamine phosphate (50 mg/kg) produces maximal stimulation of gastric acid secretion and is free from toxic effects in the unanaesthetized intact rat. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

 Water 42 mg/mL
(136.74 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 307.14
Formula

C5H9N.2H3O4P
CAS No. 51-74-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=C(NC=N1)CCN.OP(=O)(O)O.OP(=O)(O)O

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04828317 Not yet recruiting Other: Pork Challenge Allergy;Food University of Virginia May 1 2021 Not Applicable
NCT04699604 Recruiting Drug: Levocetirizine Dihydrochloride|Drug: Placebo Allergic Asthma Children''s Mercy Hospital Kansas City April 28 2021 Phase 3
NCT04913623 Recruiting Procedure: Hip Replacement Arthroplasty Complications University Clinical Centre of Kosova March 23 2021 --
NCT04534036 Recruiting Dietary Supplement: PDS-08|Other: Placebo Constipation|Signs and Symptoms|Digestive Signs and Symptoms|Infrequent or Difficult Evacuation Seed Health|Curebase Inc. August 13 2020 Not Applicable
NCT05022108 Completed Biological: Alpha bisabolol gel Wounds and Injuries Universidade do Vale do Sapucai April 1 2020 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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