Home Neuronal Signaling Histamine Receptor antagonist Promethazine

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Promethazine Histamine Receptor antagonist

Cat.No.S5196

Promethazine is a potent histamine H1 receptor antagonist. This compound is a medication used in the management and treatment of allergic conditions, nausea and vomiting, motion sickness, and sedation. It exhibits antiparasitic properties.
Promethazine Histamine Receptor antagonist Chemical Structure

Chemical Structure

Molecular Weight: 284.42

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Quality Control

Batch: S519601 DMSO]29 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.61%
99.61

Solubility

In vitro
Batch:

DMSO : 29 mg/mL (101.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 284.42 Formula

C17H20N2S

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 60-87-7 -- Storage of Stock Solutions

Synonyms N/A SMILES CC(CN1C2=CC=CC=C2SC3=CC=CC=C13)N(C)C

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC50/Ki
histamine H1 receptor
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-01-23)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07364344 NOT_YET_RECRUITING
Acute Ischemic Stroke
Ji Xunming,MD,PhD
 2026-01
NCT06663631 RECRUITING
Acute Ischemic Stroke
Capital Medical University
 2024-11-09 PHASE1
NCT05586763 UNKNOWN
Peripheral Vertigo
Oman Medical Speciality Board
 2022-02-01 PHASE3
NCT05759481 Recruiting
Post-operative Nausea and Vomiting
Milton S. Hershey Medical Center
 2024-02-01 Phase 2
NCT01391962 COMPLETED
Sarcoma, Alveolar Soft Part
National Cancer Institute (NCI)
 2011-07-18 PHASE2
NCT04805073 Recruiting
Pruritus|Pregnancy Related
University of Florida
 2021-08-09 Phase 4

Read more about Clinical Trials

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