Catalog No.S1801 Synonyms: AH19065
Molecular Weight(MW): 350.86
Ranitidine is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers.
Purity & Quality Control
Choose Selective Histamine Receptor Inhibitors
|Description||Ranitidine is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers.|
Ranitidine sensitizes hepatocytes to killing by cytotoxic products from activated neutrophils, whereas Famotidine lacks this ability.  Ranitidine inhibits the production of tumor necrosis factor-alpha (TNF-alpha) in monocytes stimulated with lipopolysaccharide in vitro.  Ranitidine reduces the Kel of morphine dose-dependently with a maximum effect of 50%, and increases the relative concentration of morphine-6-glucuronide to morphine-3-glucuronide in isolated guinea pig hepatocytes. Ranitidine gradually decreases the morphine-3-glucuronide/morphine-6-glucuronide ratio by up to 21%. 
|In vivo||Ranitidine results in liver injury as evidence by increased in serum alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase activities within 6 hours after Ranitidine administration in rats.  Ranitidine inhibits hepatic ischemia/reperfusion-induced increase in hepatic tissue levels of TNF-alpha, cytokine-induced neutrophil chemoattractant, and hepatic accumulation of neutrophils in rats.  Ranitidine cotreatment enhances LPS-induced coagulation prior to liver injury, and anticoagulants reduce liver damage in LPS/RAN-treated rats. Ranitidine /LPS-treated rats results in the formation of fibrin clots in liver sinusoids, and prevention of fibrin deposition associated with reduced hepatocellular injury. Ranitidine cotreatment enhances the LPS-induced TNF increase before the onset of hepatocellular injury in rats.  Ranitidine displays anxiolytic effects in the elevated plus-maze as indicated by an increase in time spent in the open arms, more open-arm scanning and more end-excursions in rats. |
-  Luyendyk JP, et al. J Pharmacol Exp Ther,?003, 307(1), 9-16.
-  Okajima K, et al. J Pharmacol Exp Ther,?002, 301(3), 1157-1165.
-  Aasmundstad TA, et al. Pharmacol Toxicol, 1998, 82(6), 272-279.
|In vitro||DMSO||70 mg/mL (199.5 mM)|
|Water||70 mg/mL (199.5 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT01908257||Completed||Healthy||Ardea Biosciences Inc.||July 2013||Phase 1|
|NCT02197143||Completed||Dyspepsia||Pamukkale University||March 2013||Phase 4|
|NCT01737840||Completed||Dyspepsia||Akdeniz University||October 2012||Phase 4|
|NCT01682408||Completed||Pharmacokinetics||AstraZeneca||September 2012||Phase 1|
|NCT01539655||Completed||Medullary Thyroid Cancer||Sanofi||February 2012||Phase 1|
|NCT01392755||Completed||Healthy Volunteer||Hoffmann-La Roche||July 2011||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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