Catalog No.S1801 Synonyms: AH19065
Molecular Weight(MW): 350.86
Ranitidine is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers.
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Choose Selective Histamine Receptor Inhibitors
|Description||Ranitidine is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers.|
Ranitidine sensitizes hepatocytes to killing by cytotoxic products from activated neutrophils, whereas Famotidine lacks this ability.  Ranitidine inhibits the production of tumor necrosis factor-alpha (TNF-alpha) in monocytes stimulated with lipopolysaccharide in vitro.  Ranitidine reduces the Kel of morphine dose-dependently with a maximum effect of 50%, and increases the relative concentration of morphine-6-glucuronide to morphine-3-glucuronide in isolated guinea pig hepatocytes. Ranitidine gradually decreases the morphine-3-glucuronide/morphine-6-glucuronide ratio by up to 21%. 
|In vivo||Ranitidine results in liver injury as evidence by increased in serum alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase activities within 6 hours after Ranitidine administration in rats.  Ranitidine inhibits hepatic ischemia/reperfusion-induced increase in hepatic tissue levels of TNF-alpha, cytokine-induced neutrophil chemoattractant, and hepatic accumulation of neutrophils in rats.  Ranitidine cotreatment enhances LPS-induced coagulation prior to liver injury, and anticoagulants reduce liver damage in LPS/RAN-treated rats. Ranitidine /LPS-treated rats results in the formation of fibrin clots in liver sinusoids, and prevention of fibrin deposition associated with reduced hepatocellular injury. Ranitidine cotreatment enhances the LPS-induced TNF increase before the onset of hepatocellular injury in rats.  Ranitidine displays anxiolytic effects in the elevated plus-maze as indicated by an increase in time spent in the open arms, more open-arm scanning and more end-excursions in rats. |
-  Luyendyk JP, et al. J Pharmacol Exp Ther,?003, 307(1), 9-16.
-  Okajima K, et al. J Pharmacol Exp Ther,?002, 301(3), 1157-1165.
-  Aasmundstad TA, et al. Pharmacol Toxicol, 1998, 82(6), 272-279.
|In vitro||DMSO||70 mg/mL (199.5 mM)|
|Water||70 mg/mL (199.5 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT01539655||Completed||Drug: vandetanib|Drug: omeprazole|Drug: ranitidine||Medullary Thyroid Cancer||Sanofi||February 2012||Phase 1|
|NCT01017198||Completed||Drug: BIIB021 and Food|Drug: BIIB0121 and Antacid||Advanced Solid Tumors||Biogen||November 2009||Phase 1|
|NCT00401752||Completed||Drug: Esomeprazole|Drug: Ranitidine||Gastric Ulcer||AstraZeneca||March 2006||Phase 3|
|NCT00633672||Completed||Drug: Esomeprazole|Drug: Ranitidine||NSAID Associated Gastric Ulcers||AstraZeneca||February 2001||Phase 3|
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