Ranitidine Hydrochloride

Catalog No.S1801 Synonyms: AH19065

Ranitidine Hydrochloride Chemical Structure

Molecular Weight(MW): 350.86

Ranitidine is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers.

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In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Ranitidine is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers.
Histamine H2 receptor [1]
In vitro

Ranitidine sensitizes hepatocytes to killing by cytotoxic products from activated neutrophils, whereas Famotidine lacks this ability. [1] Ranitidine inhibits the production of tumor necrosis factor-alpha (TNF-alpha) in monocytes stimulated with lipopolysaccharide in vitro. [2] Ranitidine reduces the Kel of morphine dose-dependently with a maximum effect of 50%, and increases the relative concentration of morphine-6-glucuronide to morphine-3-glucuronide in isolated guinea pig hepatocytes. Ranitidine gradually decreases the morphine-3-glucuronide/morphine-6-glucuronide ratio by up to 21%. [3]

In vivo Ranitidine results in liver injury as evidence by increased in serum alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase activities within 6 hours after Ranitidine administration in rats. [1] Ranitidine inhibits hepatic ischemia/reperfusion-induced increase in hepatic tissue levels of TNF-alpha, cytokine-induced neutrophil chemoattractant, and hepatic accumulation of neutrophils in rats. [2] Ranitidine cotreatment enhances LPS-induced coagulation prior to liver injury, and anticoagulants reduce liver damage in LPS/RAN-treated rats. Ranitidine /LPS-treated rats results in the formation of fibrin clots in liver sinusoids, and prevention of fibrin deposition associated with reduced hepatocellular injury. Ranitidine cotreatment enhances the LPS-induced TNF increase before the onset of hepatocellular injury in rats. [4] Ranitidine displays anxiolytic effects in the elevated plus-maze as indicated by an increase in time spent in the open arms, more open-arm scanning and more end-excursions in rats. [5]


Solubility (25°C)

In vitro DMSO 70 mg/mL (199.5 mM)
Water 70 mg/mL (199.5 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 350.86


CAS No. 66357-59-3
Storage powder
in solvent
Synonyms AH19065

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01539655 Completed Drug: vandetanib|Drug: omeprazole|Drug: ranitidine Medullary Thyroid Cancer Sanofi February 2012 Phase 1
NCT01017198 Completed Drug: BIIB021 and Food|Drug: BIIB0121 and Antacid Advanced Solid Tumors Biogen November 2009 Phase 1
NCT00401752 Completed Drug: Esomeprazole|Drug: Ranitidine Gastric Ulcer AstraZeneca March 2006 Phase 3
NCT00633672 Completed Drug: Esomeprazole|Drug: Ranitidine NSAID Associated Gastric Ulcers AstraZeneca February 2001 Phase 3

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Histamine Receptor Signaling Pathway Map

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