Lidocaine

Catalog No.S1357 Synonyms: Alphacaine

For research use only.

Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

Lidocaine Chemical Structure

CAS No. 137-58-6

Selleck's Lidocaine has been cited by 6 Publications

Purity & Quality Control

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Biological Activity

Description Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.
Targets
Histamine H1 receptor [1]
>32 μM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 234.34
Formula

C14H22N2O

CAS No. 137-58-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN(CC)CC(=O)NC1=C(C=CC=C1C)C

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04614610 Not yet recruiting Drug: Lidocaine Iv|Drug: Placebo Sickle Cell Disease|Sickle Cell Crisis|Pain Acute Community Medical Center Toms River NJ|Newark Beth Israel Medical Center|Monmouth Medical Center|Rutgers Robert Wood Johnson Medical School October 1 2022 Phase 2
NCT05402293 Not yet recruiting Diagnostic Test: Blood samples to measure lidocaine levels Acute Pain|Lidocaine|Administration and Dosage University of Alberta August 1 2022 --
NCT05379283 Not yet recruiting Drug: Lidocaine|Other: control Sweat Pore Closure San Diego State University May 15 2022 Not Applicable
NCT05238506 Recruiting Drug: Intravenous lidocaine|Drug: Normal saline infusion Hemodynamic Response|Acute Appendicitis|Complication of Treatment|Opioid Consumption|Pneumoperitoneum Medical University of Warsaw March 12 2022 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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