Catalog No.S1357 Synonyms: Alphacaine

For research use only.

Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

Lidocaine Chemical Structure

CAS No. 137-58-6

Selleck's Lidocaine has been cited by 5 Publications

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Biological Activity

Description Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.
Histamine H1 receptor [1]
>32 μM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 47 mg/mL
(200.56 mM)
Ethanol 47 mg/mL
(200.56 mM)
Water 9 mg/mL
(38.4 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 234.34


CAS No. 137-58-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN(CC)CC(=O)NC1=C(C=CC=C1C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05153785 Recruiting Drug: Lidocaine|Drug: Normal saline Liver Metastases|Liver Cancer|Postoperative Pain|Opioid Use Lund University Hospital November 15 2021 Phase 2|Phase 3
NCT03095404 Withdrawn Drug: Low Dose Lidocaine|Drug: High Dose Lidocaine Bariatric Surgery Candidate McMaster University|St. Joseph''s Healthcare Hamilton September 2021 Early Phase 1
NCT05010148 Recruiting Drug: Lidocaine IV|Drug: Placebo Postoperative Delirium|Postoperative Pain|Spinal Fusion University of California San Francisco September 17 2021 Phase 3
NCT05063578 Recruiting Drug: Lidocaine 2% Injectable Solution Anesthesia Far Eastern Memorial Hospital September 20 2021 Not Applicable

(data from, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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