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Lidocaine

Name: Lidocaine
Brand: Selleck Chemicals
SKU: S1357
Rating: 5 (6 reviews)

Synonyms: Alphacaine

Catalog No.S1357 Purity: 99.97%

Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

Lidocaine Chemical Structure

CAS: 137-58-6

Selleck's Lidocaine has been cited by 6 publications

Purity & Quality Control

Batch: S135701 DMSO] 47 mg/mL] false] Ethanol] 47 mg/mL] false] Water] 9 mg/mL] false Purity: 99.97%

99.97

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Signaling Pathway

Histamine Receptor Signaling Pathway

Choose Selective Histamine Receptor Inhibitors

Biological Activity

Description

Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

Targets

Histamine H1 receptor ^[1]

>32 μM

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05402293	Not yet recruiting	Acute Pain\|Lidocaine\|Administration and Dosage	University of Alberta	January 15 2024	--
NCT04614610	Not yet recruiting	Sickle Cell Disease\|Sickle Cell Crisis\|Pain Acute	Community Medical Center Toms River NJ\|Newark Beth Israel Medical Center\|Monmouth Medical Center\|Rutgers Robert Wood Johnson Medical School	January 1 2024	Phase 2
NCT06135688	Recruiting	Anesthesia Brain Monitoring\|Lidocaine	University of Padova	November 18 2023	--
NCT06122324	Enrolling by invitation	Postoperative Sore Throat	Dr. Lutfi Kirdar Kartal Training and Research Hospital	October 30 2023	--

References

[1] Van Der Wal S, et al. Acta Anaesthesiol Scand, 2015, 59(1):47-55.

Chemical Information & Solubility

Molecular Weight	234.34	Formula	C₁₄H₂₂N₂O
CAS No.	137-58-6	SDF	Download Lidocaine SDF
Smiles	CCN(CC)CC(=O)NC1=C(C=CC=C1C)C
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 47 mg/mL ( (200.56 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 47 mg/mL

Water : 9 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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