Name: Lidocaine
Brand: Selleck Chemicals
SKU: S1357
Availability: InStock
Rating: 5 (8 reviews)

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Quality Control

Batch: S135701 DMSO]47 mg/mL]false]Ethanol]47 mg/mL]false]Water]9 mg/mL]false Purity: 99.97%

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COA
NMR
SDS/MSDS
Datasheet

99.97

Related Targets	Adrenergic Receptor AChR 5-HT Receptor COX Calcium Channel Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE) GluR
Other Histamine Receptor Inhibitors	GSK2879552 Dihydrochloride JNJ-7777120 Mianserin HCl Ebastine Astemizole Ciproxifan Maleate Rupatadine Lafutidine Cloperastine hydrochloride Mizolastine

Solubility

In vitro
Batch:

DMSO : 47 mg/mL (200.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 47 mg/mL

Water : 9 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.35mg/ml (10.03mM)	Taking the 1 mL working solution as an example, add 50 μL of 47 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5 %DMSO 1 95 %Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.34mg/ml (1.45mM)	Taking the 1 mL working solution as an example, add 50 μL of 6.8 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	234.34	Formula	C₁₄H₂₂N₂O	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	137-58-6	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Alphacaine			SMILES	CCN(CC)CC(=O)NC1=C(C=CC=C1C)C

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	Histamine H1 receptor >32 μM
References	[1] https://pubmed.ncbi.nlm.nih.gov/25312651/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-01-23)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07361549	NOT_YET_RECRUITING	Refractory Migraine; Headache	Daniel A Tonetti, MD	2026-03	PHASE2
NCT07793552	NOT_YET_RECRUITING	Vulvar Cancers; Vulva Neoplasm; Vulvar Dysplasia	Tufts Medical Center	2026-11
NCT07709390	RECRUITING	Emergency Coughing	Ohio State University	2023-05-31	EARLY_PHASE1
NCT07631364	NOT_YET_RECRUITING	Neisseria Gonorrhoeae (Ng) Infections	Assistance Publique - Hôpitaux de Paris	2026-09	PHASE3
NCT07794878	RECRUITING	Nasolabial Folds	AbbVie	2026-08-19	PHASE3
NCT07778043	NOT_YET_RECRUITING	Myofacial Pain; Pelvic Pain	Women and Infants Hospital of Rhode Island	2026-08-17	PHASE4

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Lidocaine Histamine Receptor agonist

Chemical Structure

Molecular Weight: 234.34