For research use only.

Catalog No.S1357 Synonyms: Alphacaine

5 publications

Lidocaine Chemical Structure

CAS No. 137-58-6

Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

Selleck's Lidocaine has been cited by 5 publications

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Biological Activity

Description Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.
Histamine H1 receptor [1]
>32 μM


Solubility (25°C)

In vitro DMSO 47 mg/mL (200.56 mM)
Ethanol 47 mg/mL (200.56 mM)
Water 9 mg/mL (38.4 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 234.34


CAS No. 137-58-6
Storage powder
in solvent
Synonyms Alphacaine
Smiles CCN(CC)CC(=O)NC1=C(C=CC=C1C)C

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03095404 Not yet recruiting Drug: Low Dose Lidocaine|Drug: High Dose Lidocaine Bariatric Surgery Candidate McMaster University|St. Joseph''s Healthcare Hamilton September 2021 Early Phase 1
NCT05010148 Not yet recruiting Drug: Lidocaine IV|Drug: Placebo Postoperative Delirium|Postoperative Pain|Spinal Fusion University of California San Francisco August 2021 Phase 3
NCT04192773 Recruiting Drug: IV Lidocaine Tinnitus Massachusetts Eye and Ear Infirmary April 28 2021 Early Phase 1
NCT04638816 Completed Device: Restylane Volyme|Device: Restylane Lyft Lidocaine Cheek Augmentation Q-Med AB April 16 2021 Not Applicable

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Histamine Receptor Signaling Pathway Map

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