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Doxylamine Succinate Histamine Receptor inhibitor

Cat.No.S4240

Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects.
Doxylamine Succinate Histamine Receptor inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 388.46

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Quality Control

Batch: S424001 DMSO]78 mg/mL]false]Water]78 mg/mL]false]Ethanol]78 mg/mL]false Purity: 99.72%
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99.72

Solubility

In vitro
Batch:

DMSO : 78 mg/mL (200.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 78 mg/mL

Ethanol : 78 mg/mL

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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 388.46 Formula

C17H22N2O.C4H6O4

 Storage (From the date of receipt)
CAS No. 562-10-7 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CC(C1=CC=CC=C1)(C2=CC=CC=N2)OCCN(C)C.C(CC(=O)O)C(=O)O

Mechanism of Action

Targets/IC50/Ki
Histamine H1 receptor
In vivo
The effects of doxylamine (as the succinate salt) on microsomal enzyme activity and serum thyroid hormone levels are examined in B6C3F1 mice following dietary exposure for 7 or 15 days (0, 40, 375, 750, or 1500 ppm in diet, expressed as free base doxylamine). The results suggest that doxylamine is a phenobarbital-type inducer of liver microsomal cytochrome P450 in B6C3F1 mice, and consistent with the hypothesis that doxylamine increases the activity of those hepatic enzymes involved in T4 metabolism.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05498233 Completed
Pregnancy Related|Nausea
Valenta Pharm JSC
 August 18 2022 Not Applicable
NCT00796315 Completed
Allergic Rhinitis|Upper Respiratory Infection
Procter and Gamble|Consumer Healthcare Products Association
 December 2008 Phase 1

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