Histamine 2HCl

For research use only.

Catalog No.S4118

1 publication

Histamine 2HCl Chemical Structure

CAS No. 56-92-8

Histamine is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2.

Selleck's Histamine 2HCl has been cited by 1 publication

Purity & Quality Control

Choose Selective Histamine Receptor Inhibitors

Biological Activity

Description Histamine is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2.
Targets
Histamine H1 receptor [3] Histamine H2 receptor [1]
In vitro

Histamine suppresses the generation of ROS through the Histaminetype-2 receptor (H2 receptor).[1] Histamine inhibits the generation and release of reactive oxygen species (ROS) by monocytes/macrophages (MO) during respiratory burst. Histamine and interleukin-2 (IL-2) act synergistically to activate NK cell cytotoxicity (NKCC). Histamine combined with IL-2 might improve response rates and disease-free survival by protecting the cells of the immune system from oxidative stress and inducing natural endogenous immune cytotoxicity. [2]

In vivo Histamine treatment (0.5 mg/kg or 5.0 mg/kg, twice daily) protects against liver injury as evident by normal serum transaminase levels and significantly reduced liver pathology scores in a rat model with early alcohol-induced liver injury. The protective effect of histamine is blocked by Ranitidine (10 mg/kg), an H2 receptor antagonist, indicating that the histamine effect is predominantly mediated through the H2 receptor. [1] Histamine (30 pg/rat, icv) increases both 3,4-dihydroxyphenylalanine accumulation and 3,4-dihydroxyphenylalanine acid concentrations in the nucleus accumbens in male rats, and this effect is not affect by H2 antagonist zolantidine, indicating that histamine stimulates mesolimbic DA neurons through an action at the H1 receptor. [3] Histamine (0.5 mg/kg s.c.) reduces the liver tumour weight by 46% and subcutaneous tumour weight by 41% versus rats receiving subcutaneous saline injections. The anti-tumour effect observed by subcutaneous histamine injections is inhibited by Ranitidine (50 mg/kg s.c.) in rats sarcoma. [4] Histamine (1000 mg/kg s.c.) displays acute tissue damage after 24 hours and indications of pathological inflammation at the injection sites at 5 days and 28 days in Sprague-Dawley rats. Histamine (1000 mg/kg s.c.) results in Cmax of 167 mM, tmax of 0.5 hour, t1/2 of 0.95 and AUC of 186 mmol-h/L in male Sprague-Dawley rats. [5]

Protocol

Solubility (25°C)

In vitro Water 37 mg/mL (201.01 mM)
DMSO 3 mg/mL (16.29 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 184.07
Formula

C5H9N3.2HCl

CAS No. 56-92-8
Storage powder
in solvent
Synonyms N/A
Smiles C1=C(NC=N1)CCN.Cl.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04828317 Not yet recruiting Other: Pork Challenge Allergy;Food University of Virginia May 1 2021 Not Applicable
NCT04699604 Recruiting Drug: Levocetirizine Dihydrochloride|Drug: Placebo Allergic Asthma Children''s Mercy Hospital Kansas City April 28 2021 Phase 3
NCT04913623 Recruiting Procedure: Hip Replacement Arthroplasty Complications University Clinical Centre of Kosova March 23 2021 --
NCT04534036 Recruiting Dietary Supplement: PDS-08|Other: Placebo Constipation|Signs and Symptoms|Digestive Signs and Symptoms|Infrequent or Difficult Evacuation Seed Health|Curebase Inc. August 13 2020 Not Applicable
NCT05022108 Completed Biological: Alpha bisabolol gel Wounds and Injuries Universidade do Vale do Sapucai April 1 2020 Phase 1
NCT04439955 Recruiting Drug: CBD Chronic Spontaneous Urticaria Stero Biotechs Ltd. February 1 2020 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Histamine Receptor Signaling Pathway Map

Related Histamine Receptor Products

Tags: buy Histamine 2HCl | Histamine 2HCl ic50 | Histamine 2HCl price | Histamine 2HCl cost | Histamine 2HCl solubility dmso | Histamine 2HCl purchase | Histamine 2HCl manufacturer | Histamine 2HCl research buy | Histamine 2HCl order | Histamine 2HCl mouse | Histamine 2HCl chemical structure | Histamine 2HCl mw | Histamine 2HCl molecular weight | Histamine 2HCl datasheet | Histamine 2HCl supplier | Histamine 2HCl in vitro | Histamine 2HCl cell line | Histamine 2HCl concentration | Histamine 2HCl nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID