Histamine 2HCl

For research use only.

Catalog No.S4118

1 publication

Histamine 2HCl Chemical Structure

Molecular Weight(MW): 184.07

Histamine is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2.

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10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
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Selleck's Histamine 2HCl has been cited by 1 publication

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Biological Activity

Description Histamine is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2.
Histamine H1 receptor [3] Histamine H2 receptor [1]
In vitro

Histamine suppresses the generation of ROS through the Histaminetype-2 receptor (H2 receptor).[1] Histamine inhibits the generation and release of reactive oxygen species (ROS) by monocytes/macrophages (MO) during respiratory burst. Histamine and interleukin-2 (IL-2) act synergistically to activate NK cell cytotoxicity (NKCC). Histamine combined with IL-2 might improve response rates and disease-free survival by protecting the cells of the immune system from oxidative stress and inducing natural endogenous immune cytotoxicity. [2]

In vivo Histamine treatment (0.5 mg/kg or 5.0 mg/kg, twice daily) protects against liver injury as evident by normal serum transaminase levels and significantly reduced liver pathology scores in a rat model with early alcohol-induced liver injury. The protective effect of histamine is blocked by Ranitidine (10 mg/kg), an H2 receptor antagonist, indicating that the histamine effect is predominantly mediated through the H2 receptor. [1] Histamine (30 pg/rat, icv) increases both 3,4-dihydroxyphenylalanine accumulation and 3,4-dihydroxyphenylalanine acid concentrations in the nucleus accumbens in male rats, and this effect is not affect by H2 antagonist zolantidine, indicating that histamine stimulates mesolimbic DA neurons through an action at the H1 receptor. [3] Histamine (0.5 mg/kg s.c.) reduces the liver tumour weight by 46% and subcutaneous tumour weight by 41% versus rats receiving subcutaneous saline injections. The anti-tumour effect observed by subcutaneous histamine injections is inhibited by Ranitidine (50 mg/kg s.c.) in rats sarcoma. [4] Histamine (1000 mg/kg s.c.) displays acute tissue damage after 24 hours and indications of pathological inflammation at the injection sites at 5 days and 28 days in Sprague-Dawley rats. Histamine (1000 mg/kg s.c.) results in Cmax of 167 mM, tmax of 0.5 hour, t1/2 of 0.95 and AUC of 186 mmol-h/L in male Sprague-Dawley rats. [5]


Solubility (25°C)

In vitro Water 37 mg/mL (201.01 mM)
DMSO 3 mg/mL (16.29 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 184.07


CAS No. 56-92-8
Storage powder
in solvent
Synonyms N/A
Smiles Cl.Cl.NCCC1=C[NH]C=N1

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04286542 Recruiting Diagnostic Test: Cold dry air Hyperactivity|Allergic Rhinitis Due to House Dust Mite|Chronic Rhinosinusitis With Nasal Polyps Universitaire Ziekenhuizen Leuven January 20 2020 Not Applicable
NCT03930537 Completed Device: Hip replacement Arthroplasty Complications University Clinical Centre of Kosova March 17 2019 Not Applicable
NCT03826004 Completed Drug: Clemastine|Drug: Saline Solution Efficacy and Safety Chinese Academy of Medical Sciences Fuwai Hospital February 20 2019 Not Applicable

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Histamine Receptor Signaling Pathway Map

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