Pemirolast potassium

Catalog No.S4008 Synonyms: BMY26517

For research use only.

Pemirolast potassium (BMY26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

Pemirolast potassium Chemical Structure

CAS No. 100299-08-9

Selleck's Pemirolast potassium has been cited by 2 Publications

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Biological Activity

Description Pemirolast potassium (BMY26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.
Targets
Histamine H1 receptor [2]
In vitro

Pemirolast potassium (BMY 26517) is a new oral, nonbronchodilator antiallergy medication that is being evaluated for the therapy of asthma. [1] Pemirolast potassium (BMY 26517) inhibits chemical mediator release from tissue mast cells and is also shown to inhibit the release of peptides including substance P, [2] neurokinin (NK) A, and calcitonin gene-related peptide (CGRP) from sensory nerves. [3] Pemirolast potassium is used for the treatment of allergic conjunctivitis and prophylaxis for pulmonary hypersensitivity reactions to drugs such as paclitaxel. [4]

In vivo Pemirolast potassium (BMY 26517) reduces kaolin intake by inhibition of substance P release in rats. [2] Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats. [3]

Protocol (from reference)

Solubility (25°C)

In vitro

Water 53 mg/mL
(199.02 mM)
DMSO Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 266.3
Formula

C10H7N6O.K

CAS No. 100299-08-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC=CN2C1=NC=C(C2=O)C3=NN=N[N-]3.[K+]

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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