Pemirolast potassium

For research use only.

Catalog No.S4008 Synonyms: BMY26517

2 publications

Pemirolast potassium Chemical Structure

CAS No. 100299-08-9

Pemirolast potassium (BMY26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

Selleck's Pemirolast potassium has been cited by 2 publications

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Biological Activity

Description Pemirolast potassium (BMY26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.
Histamine H1 receptor [2]
In vitro

Pemirolast potassium (BMY 26517) is a new oral, nonbronchodilator antiallergy medication that is being evaluated for the therapy of asthma. [1] Pemirolast potassium (BMY 26517) inhibits chemical mediator release from tissue mast cells and is also shown to inhibit the release of peptides including substance P, [2] neurokinin (NK) A, and calcitonin gene-related peptide (CGRP) from sensory nerves. [3] Pemirolast potassium is used for the treatment of allergic conjunctivitis and prophylaxis for pulmonary hypersensitivity reactions to drugs such as paclitaxel. [4]

In vivo Pemirolast potassium (BMY 26517) reduces kaolin intake by inhibition of substance P release in rats. [2] Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats. [3]


Solubility (25°C)

In vitro Water 53 mg/mL (199.02 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 266.3


CAS No. 100299-08-9
Storage powder
in solvent
Synonyms BMY26517
Smiles CC1=CC=CN2C1=NC=C(C2=O)C3=NN=N[N-]3.[K+]

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Histamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID