Pemirolast potassium

Synonyms: BMY26517

Pemirolast potassium (BMY26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

Pemirolast potassium Chemical Structure

Pemirolast potassium Chemical Structure

CAS: 100299-08-9

Selleck's Pemirolast potassium has been cited by 2 publications

Purity & Quality Control

Batch: S400801 Water] 53 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.97%
99.97

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Biological Activity

Description Pemirolast potassium (BMY26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.
Targets
Histamine H1 receptor [2]
In vitro
In vitro Pemirolast potassium (BMY 26517) is a new oral, nonbronchodilator antiallergy medication that is being evaluated for the therapy of asthma. [1] Pemirolast potassium (BMY 26517) inhibits chemical mediator release from tissue mast cells and is also shown to inhibit the release of peptides including substance P, [2] neurokinin (NK) A, and calcitonin gene-related peptide (CGRP) from sensory nerves. [3] Pemirolast potassium is used for the treatment of allergic conjunctivitis and prophylaxis for pulmonary hypersensitivity reactions to drugs such as paclitaxel. [4]
In Vivo
In vivo Pemirolast potassium (BMY 26517) reduces kaolin intake by inhibition of substance P release in rats. [2] Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats. [3]

Chemical Information & Solubility

Molecular Weight 266.3 Formula

C10H7N6O.K

CAS No. 100299-08-9 SDF Download Pemirolast potassium SDF
Smiles CC1=CC=CN2C1=NC=C(C2=O)C3=NN=N[N-]3.[K+]
Storage (From the date of receipt)

In vitro
Batch:

Water : 53 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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