Home Neuronal Signaling Histamine Receptor antagonist Pemirolast potassium

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Pemirolast potassium Histamine Receptor antagonist

Cat.No.S4008

Pemirolast potassium (BMY26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.
Pemirolast potassium Histamine Receptor antagonist Chemical Structure

Chemical Structure

Molecular Weight: 266.3

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Quality Control

Batch: S400801 Water]53 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.97%
99.97

Chemical Information, Storage & Stability

Molecular Weight 266.3 Formula

C10H7N6O.K

 Storage (From the date of receipt)
CAS No. 100299-08-9 Download SDF Storage of Stock Solutions

Synonyms BMY26517 Smiles CC1=CC=CN2C1=NC=C(C2=O)C3=NN=N[N-]3.[K+]

Solubility

In vitro
Batch:

Water : 53 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

Targets/IC50/Ki
Histamine H1 receptor [2]
In vitro
Pemirolast potassium (BMY 26517) is a new oral, nonbronchodilator antiallergy medication that is being evaluated for the therapy of asthma. [1] This compound inhibits chemical mediator release from tissue mast cells and is also shown to inhibit the release of peptides including substance P, [2] neurokinin (NK) A, and calcitonin gene-related peptide (CGRP) from sensory nerves. [3] It is used for the treatment of allergic conjunctivitis and prophylaxis for pulmonary hypersensitivity reactions to drugs such as paclitaxel. [4]
In vivo
Pemirolast potassium (BMY 26517) reduces kaolin intake by inhibition of substance P release in rats. [2] This compound potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats. [3]
References

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