Home Neuronal Signaling Histamine Receptor antagonist Pheniramine Maleate

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Pheniramine Maleate Histamine Receptor antagonist

Cat.No.S4045

Pheniramine Maleate is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.
Pheniramine Maleate Histamine Receptor antagonist Chemical Structure

Chemical Structure

Molecular Weight: 356.42

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Quality Control

Batch: S404501 DMSO]71 mg/mL]false]Water]71 mg/mL]false]Ethanol]71 mg/mL]false Purity: 99.92%
99.92

Solubility

In vitro
Batch:

DMSO : 71 mg/mL (199.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 71 mg/mL

Ethanol : 71 mg/mL

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 356.42 Formula

C16H20N2.C4H4O4

 Storage (From the date of receipt)
CAS No. 132-20-7 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O

Mechanism of Action

In vitro
Pheniramine Maleate is a histamine H1 antagonists with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus. Pheniramine appears to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. Antihistamines suppress the histamine-induced wheal (swelling) and flare (vasodilation) response by blocking the binding of histamine to its receptors on nerves, vascular smooth muscle, glandular cells, endothelium, and mast cells. They effectively exert competitive antagonism of histamine for H1-receptors.
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