Promethazine HCl

Catalog No.S4293

For research use only.

Promethazine HCl is a potent histamine H1 receptor antagonist, used as a sedative and antiallergic medication.

Promethazine HCl Chemical Structure

CAS No. 58-33-3

Selleck's Promethazine HCl has been cited by 3 Publications

Purity & Quality Control

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Biological Activity

Description Promethazine HCl is a potent histamine H1 receptor antagonist, used as a sedative and antiallergic medication.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 64 mg/mL
(199.45 mM)
Water 64 mg/mL
(199.45 mM)
Ethanol 34 mg/mL
(105.95 mM)

Chemical Information

Molecular Weight 320.88
Formula

C17H21ClN2S

CAS No. 58-33-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04805073 Recruiting Drug: Promethazine|Drug: Placebo Pruritus|Pregnancy Related University of Florida August 9 2021 Phase 4
NCT03539562 Completed Drug: Morphine Sulfate and Promethazine Labor Pain|Early Labor University of California San Francisco September 27 2017 --
NCT02465866 Completed Drug: CL-108|Drug: Vicoprofen|Drug: Ultracet|Drug: Phenergan Healthy Charleston Laboratories Inc November 2014 Phase 1
NCT01644838 Completed Drug: Hyoscine|Drug: Promethazine Labor Pain Mashhad University of Medical Sciences August 2010 Phase 2|Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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