Promethazine HCl

Catalog No.S4293

Promethazine HCl Chemical Structure

Molecular Weight(MW): 320.88

Promethazine HCl is a potent histamine H1 receptor antagonist, used as a sedative and antiallergic medication.

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Biological Activity

Description Promethazine HCl is a potent histamine H1 receptor antagonist, used as a sedative and antiallergic medication.



Solubility (25°C)

In vitro DMSO 64 mg/mL (199.45 mM)
Water 64 mg/mL (199.45 mM)
Ethanol 34 mg/mL (105.95 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 320.88


CAS No. 58-33-3
Storage powder
in solvent
Synonyms N/A

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03639558 Recruiting Psychiatric Emergency|Aggression|Agitation Joseph Dib|University of Nottingham|Hopital Psychiatrique De La Croix August 28 2018 Phase 4
NCT02765256 Recruiting Crohn''s Disease University of Pennsylvania|Children''s Hospital of Philadelphia|Crohn''s and Colitis Foundation August 2016 Phase 2
NCT02625181 Completed Postoperative Nausea and Vomiting Vanderbilt University|University of Washington|Vanderbilt University Medical Center July 2016 Not Applicable
NCT02374567 Terminated Dementia|Depression|Schizophrenia|Psychosomatic Disorders|Anxiety Disorders Hannover Medical School January 2015 Phase 3
NCT02462811 Completed Pain|Nausea|Vomiting Joseph Hazelton|Charleston Laboratories Inc September 2014 Phase 3
NCT02130622 Terminated Diabetic Gastroparesis Dartmouth-Hitchcock Medical Center|American College of Gastroenterology July 2014 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Histamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID