Promethazine HCl

For research use only.

Catalog No.S4293

3 publications

Promethazine HCl Chemical Structure

CAS No. 58-33-3

Promethazine HCl is a potent histamine H1 receptor antagonist, used as a sedative and antiallergic medication.

Selleck's Promethazine HCl has been cited by 3 publications

Purity & Quality Control

Choose Selective Histamine Receptor Inhibitors

Biological Activity

Description Promethazine HCl is a potent histamine H1 receptor antagonist, used as a sedative and antiallergic medication.



Solubility (25°C)

In vitro DMSO 64 mg/mL (199.45 mM)
Water 64 mg/mL (199.45 mM)
Ethanol 34 mg/mL (105.95 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 320.88


CAS No. 58-33-3
Storage powder
in solvent
Synonyms N/A
Smiles CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C.Cl

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04805073 Not yet recruiting Drug: Promethazine|Drug: Placebo Pruritus|Pregnancy Related University of Florida August 2021 Phase 4
NCT03539562 Completed Drug: Morphine Sulfate and Promethazine Labor Pain|Early Labor University of California San Francisco September 27 2017 --
NCT02465866 Completed Drug: CL-108|Drug: Vicoprofen|Drug: Ultracet|Drug: Phenergan Healthy Charleston Laboratories Inc November 2014 Phase 1
NCT01644838 Completed Drug: Hyoscine|Drug: Promethazine Labor Pain Mashhad University of Medical Sciences August 2010 Phase 2|Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Histamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID