XMD8-87

For research use only.

Catalog No.S8272

XMD8-87 Chemical Structure

Molecular Weight(MW): 445.52

XMD8-87 is a novel tyrosine kinase nonreceptor 2(TNK2) inhibitor with IC50s of 38 nmol/L and 113 nmol/L for the D163E and R806Q mutations.

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USD 147 In stock
USD 497 In stock
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Biological Activity

Description XMD8-87 is a novel tyrosine kinase nonreceptor 2(TNK2) inhibitor with IC50s of 38 nmol/L and 113 nmol/L for the D163E and R806Q mutations.
Targets
TNK2 [1]
In vitro

XMD8-87 is found to be potent in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mutations found in solid tumor types.

Protocol

Cell Research:[1]
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  • Cell lines: 293T cells
  • Concentrations: 10 nM-5 μM
  • Incubation Time: 6 h
  • Method: 293T cells expressing TNK2 are plated in 6-well format at a density of 250,000 cells per well 48 hours prior to treatment. Cells are then treated with a 100 μL of XMD8-87 or XMD16-5 at 5 μmol/L and with 9 1:1 serial dilutions down to ≈10 nmol/L. Two additional samples are treated with DMSO only. Cells are then incubated for 6 hours at 37°C. Protein extraction is accomplished by adding 300 μL of lysis buffer to cells after removing media. Plates are gently shaken for 5 minutes at room temperature. Lysates are collected and cleared of incompletely solubilized material by spinning for 10 minutes at maximum speed in a microcentrifuge. Samples are prepared for SDS-PAGE using the EPage loading buffer.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 65 mg/mL (145.89 mM)
Ethanol 5 mg/mL (11.22 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 445.52
Formula

C24H27N7O2

CAS No. 1234480-46-6
Storage powder
in solvent
Synonyms N/A
Smiles COC1=CC(=CC=C1NC2=NC3=C(NC(=O)C4=C(C=CC=C4)N3C)C=N2)N5CCN(C)CC5

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID