XL228

For research use only.

Catalog No.S1272

XL228 Chemical Structure

CAS No. 898280-07-4

XL228 is a protein kinase inhibitor with IC50 of 5 nM, 1.4 nM, 3.1 nM, 1.6 nM, 6.1 nM and 2 nM for wild-type ABL kinase, ABL T315I, Aurora A, IGF-1R, SRC and LYN, respectively.

Purity & Quality Control

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Biological Activity

Description XL228 is a protein kinase inhibitor with IC50 of 5 nM, 1.4 nM, 3.1 nM, 1.6 nM, 6.1 nM and 2 nM for wild-type ABL kinase, ABL T315I, Aurora A, IGF-1R, SRC and LYN, respectively.
Targets
ABL T315I [1]
(Cell-free assay)
IGF-1R [1]
(Cell-free assay)
LYN [1]
(Cell-free assay)
Aurora A [1]
(Cell-free assay)
wild-type ABL kinase [1]
(Cell-free assay)
1.4 nM 1.6 nM 2 nM 3.1 nM 5 nM

Protocol

Solubility (25°C)

In vitro DMSO 88 mg/mL (201.12 mM)
Ethanol 30 mg/mL (68.56 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 437.54
Formula

C22H31N9O

CAS No. 898280-07-4
Storage powder
in solvent
Synonyms N/A

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00526838 Terminated Drug: XL228 Cancer|Lymphoma Exelixis September 2007 Phase 1
NCT00464113 Terminated Drug: XL228 Chronic Myeloid Leukemia|Leukemia Lymphoblastic Acute Philadelphia-Positive Exelixis May 2007 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Bcr-Abl Signaling Pathway Map

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