Home Angiogenesis Bcr-Abl inhibitor - Aurora Kinase inhibitor - IGF-1R inhibitor - Src inhibitor XL228 For research use only.

XL228

XL228 is a protein kinase inhibitor with IC50 of 5 nM, 1.4 nM, 3.1 nM, 1.6 nM, 6.1 nM and 2 nM for wild-type ABL kinase, ABL T315I, Aurora A, IGF-1R, SRC and LYN, respectively.

XL228 Chemical Structure

XL228 Chemical Structure

CAS: 898280-07-4

Purity & Quality Control

Batch: S127201 DMSO] 88 mg/mL] false] Ethanol] 30 mg/mL] false] Water] Insoluble] false Purity: 99.85%
99.85

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Signaling Pathway

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Bcr-Abl Signaling Pathway

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Biological Activity

Description XL228 is a protein kinase inhibitor with IC50 of 5 nM, 1.4 nM, 3.1 nM, 1.6 nM, 6.1 nM and 2 nM for wild-type ABL kinase, ABL T315I, Aurora A, IGF-1R, SRC and LYN, respectively.
Targets
ABL T315I [1]
(Cell-free assay)		 IGF-1R [1]
(Cell-free assay)		 LYN [1]
(Cell-free assay)		 Aurora A [1]
(Cell-free assay)		 wild-type ABL kinase [1]
(Cell-free assay)		 Click to View More Targets
1.4 nM 1.6 nM 2 nM 3.1 nM 5 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526838 Terminated
Cancer|Lymphoma
Exelixis
 September 2007 Phase 1
NCT00464113 Terminated
Chronic Myeloid Leukemia|Leukemia Lymphoblastic Acute Philadelphia-Positive
Exelixis
 May 2007 Phase 1

Chemical Information & Solubility

Molecular Weight 437.54 Formula

C22H31N9O
CAS No. 898280-07-4 SDF --
Smiles CC(C)C1=NOC(=C1)CNC2=NC(=CC(=N2)N3CCN(C)CC3)NC4=N[NH]C(=C4)C5CC5
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 88 mg/mL ( (201.12 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 30 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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