Home Methylation PRMT chemical XY1

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XY1 PRMT chemical

Cat.No.S0184

XY1 is an inactive, close analog of SGC707 that can be used as the negative control for SGC707. SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 and Kd of 31 nM and 53 nM, respectively.
XY1 PRMT chemical Chemical Structure

Chemical Structure

Molecular Weight: 297.35

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S018401 DMSO]59 mg/mL]false]Ethanol]1 mg/mL]false]Water]˂1 mg/mL]false Purity: 99.43%
99.43

Chemical Information, Storage & Stability

Molecular Weight 297.35 Formula

C17H19N3O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1624117-53-8 -- Storage of Stock Solutions

Synonyms N/A Smiles C1CCN(C1)C(=O)CNC(=O)NC2=CC3=CC=CC=C3C=C2

Solubility

In vitro
Batch:

DMSO : 59 mg/mL (198.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 1 mg/mL

Water : ˂1 mg/mL

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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g
μL

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% DMSO
%
% Tween 80
% ddH2O
% DMSO
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
PRMT3 [1]
(Cell-free assay)
31 nM
PRMT3 [1]
(Cell-free assay)
53 nM(Kd)
References

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