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  • HIV Protease Inhibitors (19)
  • New HIV Protease Products
Catalog No. Product Name Information Product Use Citations Product Validations
S1030 Panobinostat (LBH589) Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.
Nat Med, 2021, 10.1038/s41591-020-01212-6
Cell Stem Cell, 2021, 28(1):48-62.e6
Hepatology, 2021, 10.1002/hep.32245
S1185 Ritonavir (ABT-538) Ritonavir (ABT-538, A 84538, RTV, Norvir, Norvir Softgel) is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.
mBio, 2021, 12(1)e02754-20
Cell Chem Biol, 2021, S2451-9456(21)00441-4
J Antimicrob Chemother, 2021, 76(7):1874-1885
S1380 Lopinavir (ABT-378) Lopinavir (ABT-378) is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay.
mBio, 2021, 12(1)e02754-20
J Antimicrob Chemother, 2021, 76(7):1874-1885
Antiviral Res, 2021, 185:104996
S1457 Atazanavir (BMS-232632) Sulfate Atazanavir Sulfate (BMS-232632) is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.
Sci Rep, 2021, 11(1):19443
Front Cardiovasc Med, 2021, 8:634774
Hum Cell, 2021, 10.1007/s13577-021-00579-z
S1620 Darunavir Ethanolate Darunavir Ethanolate (TMC-114, UIC 94017) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.
Sci Rep, 2021, 11(1):19443
Antimicrob Agents Chemother, 2020, AAC.00872-20
J Virol, 2019, 93(9)
S1639 Amprenavir (VX-478) Amprenavir (VX-478, 141W94, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.
Sci Rep, 2021, 11(1):19443
Antimicrob Agents Chemother, 2020, AAC.00872-20
S2319 Limonin Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.
Int J Biol Sci, 2019, 15(11):2497-2508
Food Chem Toxicol, 2019, 125:621-628
Biomed Pharmacother, 2019, 118:109366
S3287 Rosamultin Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H2O2-induced oxidative damage and apoptosis.
S4282 Nelfinavir (AG 1343) Mesylate Nelfinavir Mesylate (Viracept, AG1343) is a potent HIV protease inhibitor with Ki of 2 nM.
Cell Rep, 2021, 35(10):109218
Protein Cell, 2021, 10.1007/s13238-021-00885-0
Sci Rep, 2021, 11(1):19443
S4662 Atazanavir Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.
Sci Rep, 2021, 11(1):19443
Front Cardiovasc Med, 2021, 8:634774
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
S5250 Darunavir Darunavir (TMC114) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.
Sci Rep, 2021, 11(1):19443
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
Antimicrob Agents Chemother, 2020, AAC.00872-20
S6581 Fosamprenavir calcium salt Fosamprenavir is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections.
Antimicrob Agents Chemother, 2020, AAC.00872-20
S6625 Temsavir (BMS-626529) Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses.
S6929 Dextran sulfate sodium (DSS) Dextran sulfate sodium (DSS) is a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro that inhibits virus adsorption to the host cells.
S6999New Chloroquine (NSC-187208) Chloroquine (NSC-187208, Aralen, CHQ, CQ) is an antimalarial drug and autophagy/lysosome inhibitor. Chloroquine also suppresses Toll-like receptor-9 (TLR9) protein expression. Chloroquine is highly effective agianst SARS-CoV-2 (COVID-19) infection with EC50 of 1.13 μM in Vero E6 cells. Chloroquine has anti-HIV-1 activity.
Bone, 2022, 154:116262
Dev Cell, 2021, 56(16):2313-2328.e7
Autophagy, 2021, 10.1080/15548627.2021.1912270
S7381 Pepstatin A Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.
Pharmacol Res, 2021, S1043-6618(21)00517-X
J Virol, 2021, JVI0155021
Acta Pharmacol Sin, 2021, 10.1038/s41401-021-00768-4
S9010 Bevirimat Bevirimat (MPC-4326, PA-457, YK-FH312), the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients.
S9567 Indinavir Sulfate Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.
Mol Metab, 2020, 29;101027
Antimicrob Agents Chemother, 2020, AAC.00872-20
Mol Ther, 2018, 26(6):1435-1446
S9625New Saquinavir (Ro 31-8959) Saquinavir (Ro 31-8959) is a potent and selective inhibitor of HIV proteinase with a mean IC50 of 2.7 nM in JM cells.
S1030 Panobinostat (LBH589) Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.
Nat Med, 2021, 10.1038/s41591-020-01212-6
Cell Stem Cell, 2021, 28(1):48-62.e6
Hepatology, 2021, 10.1002/hep.32245
S1185 Ritonavir (ABT-538) Ritonavir (ABT-538, A 84538, RTV, Norvir, Norvir Softgel) is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.
mBio, 2021, 12(1)e02754-20
Cell Chem Biol, 2021, S2451-9456(21)00441-4
J Antimicrob Chemother, 2021, 76(7):1874-1885
S1380 Lopinavir (ABT-378) Lopinavir (ABT-378) is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay.
mBio, 2021, 12(1)e02754-20
J Antimicrob Chemother, 2021, 76(7):1874-1885
Antiviral Res, 2021, 185:104996
S1457 Atazanavir (BMS-232632) Sulfate Atazanavir Sulfate (BMS-232632) is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.
Sci Rep, 2021, 11(1):19443
Front Cardiovasc Med, 2021, 8:634774
Hum Cell, 2021, 10.1007/s13577-021-00579-z
S1620 Darunavir Ethanolate Darunavir Ethanolate (TMC-114, UIC 94017) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.
Sci Rep, 2021, 11(1):19443
Antimicrob Agents Chemother, 2020, AAC.00872-20
J Virol, 2019, 93(9)
S1639 Amprenavir (VX-478) Amprenavir (VX-478, 141W94, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.
Sci Rep, 2021, 11(1):19443
Antimicrob Agents Chemother, 2020, AAC.00872-20
S2319 Limonin Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.
Int J Biol Sci, 2019, 15(11):2497-2508
Food Chem Toxicol, 2019, 125:621-628
Biomed Pharmacother, 2019, 118:109366
S3287 Rosamultin Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H2O2-induced oxidative damage and apoptosis.
S4282 Nelfinavir (AG 1343) Mesylate Nelfinavir Mesylate (Viracept, AG1343) is a potent HIV protease inhibitor with Ki of 2 nM.
Cell Rep, 2021, 35(10):109218
Protein Cell, 2021, 10.1007/s13238-021-00885-0
Sci Rep, 2021, 11(1):19443
S4662 Atazanavir Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.
Sci Rep, 2021, 11(1):19443
Front Cardiovasc Med, 2021, 8:634774
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
S5250 Darunavir Darunavir (TMC114) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.
Sci Rep, 2021, 11(1):19443
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
Antimicrob Agents Chemother, 2020, AAC.00872-20
S6581 Fosamprenavir calcium salt Fosamprenavir is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections.
Antimicrob Agents Chemother, 2020, AAC.00872-20
S6625 Temsavir (BMS-626529) Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses.
S6929 Dextran sulfate sodium (DSS) Dextran sulfate sodium (DSS) is a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro that inhibits virus adsorption to the host cells.
S6999New Chloroquine (NSC-187208) Chloroquine (NSC-187208, Aralen, CHQ, CQ) is an antimalarial drug and autophagy/lysosome inhibitor. Chloroquine also suppresses Toll-like receptor-9 (TLR9) protein expression. Chloroquine is highly effective agianst SARS-CoV-2 (COVID-19) infection with EC50 of 1.13 μM in Vero E6 cells. Chloroquine has anti-HIV-1 activity.
Bone, 2022, 154:116262
Dev Cell, 2021, 56(16):2313-2328.e7
Autophagy, 2021, 10.1080/15548627.2021.1912270
S7381 Pepstatin A Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.
Pharmacol Res, 2021, S1043-6618(21)00517-X
J Virol, 2021, JVI0155021
Acta Pharmacol Sin, 2021, 10.1038/s41401-021-00768-4
S9010 Bevirimat Bevirimat (MPC-4326, PA-457, YK-FH312), the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients.
S9567 Indinavir Sulfate Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.
Mol Metab, 2020, 29;101027
Antimicrob Agents Chemother, 2020, AAC.00872-20
Mol Ther, 2018, 26(6):1435-1446
S9625New Saquinavir (Ro 31-8959) Saquinavir (Ro 31-8959) is a potent and selective inhibitor of HIV proteinase with a mean IC50 of 2.7 nM in JM cells.
S6999New Chloroquine (NSC-187208) Chloroquine (NSC-187208, Aralen, CHQ, CQ) is an antimalarial drug and autophagy/lysosome inhibitor. Chloroquine also suppresses Toll-like receptor-9 (TLR9) protein expression. Chloroquine is highly effective agianst SARS-CoV-2 (COVID-19) infection with EC50 of 1.13 μM in Vero E6 cells. Chloroquine has anti-HIV-1 activity.
Bone, 2022, 154:116262
Dev Cell, 2021, 56(16):2313-2328.e7
Autophagy, 2021, 10.1080/15548627.2021.1912270
S9625New Saquinavir (Ro 31-8959) Saquinavir (Ro 31-8959) is a potent and selective inhibitor of HIV proteinase with a mean IC50 of 2.7 nM in JM cells.