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HIV Protease

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HIV-1 capsid HIV-1 caspid

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HIV Protease Products

All (24)
HIV Protease Inhibitors (24)
New HIV Protease Products

Catalog No.	Product Name	Information	Product Use Citations
S1030	Panobinostat (LBH589)	Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.	Cancer Cell, 2025, 43(4):776-796.e14 Nat Commun, 2025, 16(1):2173 Nat Commun, 2025, 16(1):28
S6999	Chloroquine	Chloroquine is an antimalarial drug and autophagy/lysosome inhibitor. Chloroquine also suppresses Toll-like receptor-9 (TLR9) protein expression. Chloroquine is highly effective agianst SARS-CoV-2 (COVID-19) infection with EC50 of 1.13 μM in Vero E6 cells. Chloroquine has anti-HIV-1 activity.	Signal Transduct Target Ther, 2025, 10(1):26 Cell Discov, 2025, 11(1):15 Cell Metab, 2025, S1550-4131(25)00149-4
S1380	Lopinavir (ABT-378)	Lopinavir (ABT-378) is a potent HIV protease inhibitor with K_i of 1.3 pM in a cell-free assay.	Nat Commun, 2023, 14(1):5034 Nat Commun, 2023, 14(1):5034 Int J Mol Sci, 2023, 24(7)6062
S1185	Ritonavir	Ritonavir is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.	Vet Parasitol, 2025, 337:110471 Cell Chem Biol, 2024, S2451-9456(24)00396-9 Antiviral Res, 2024, 225:105840
S7381	Pepstatin A	Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.	Nat Commun, 2025, 16(1):4069 Cell Rep Med, 2024, 5(4):101503 Anim Nutr, 2024, 20:16:409-421.
S4282	Nelfinavir Mesylate	Nelfinavir Mesylate is a potent HIV protease inhibitor with K_i of 2 nM.	Int J Mol Sci, 2023, 24(7)6062 Int. J. Mol. Sci, 2023, 10.3390/ijms24076062 mBio, 2022, 13(1):e0304421
S1457	Atazanavir (BMS-232632) Sulfate	Atazanavir Sulfate (BMS-232632-05, Reyataz) is a HIV protease inhibitor with K_i of 2.66 nM in a cell-free assay.	bioRxiv, 2024, 2024.05.10.593637 J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y
S4662	Atazanavir	Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.	Int J Mol Sci, 2022, 23(23)15380 Chemistry, 2022, e202202798. Cells, 2021, 10(12)3458
S1620	Darunavir Ethanolate	Darunavir Ethanolate (TMC-114, UIC 94017) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.	J Virol, 2022, JVI0173021 J Cell Biochem, 2022, 10.1002/jcb.30213 Sci Rep, 2021, 11(1):19443
S5250	Darunavir	Darunavir (TMC114,DRV) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.	Front Cell Infect Microbiol, 2024, 14:1334126 PNAS Nexus, 2024, 3(1):pgad446 Antimicrob Agents Chemother, 2023, 67(7):e0046223
S9567	Indinavir Sulfate	Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.	Antimicrob Agents Chemother, 2023, 67(7):e0046223 J Cell Biochem, 2022, 10.1002/jcb.30213 Mol Metab, 2020, 29;101027
S1639	Amprenavir (VX-478)	Amprenavir (VX-478, 141W94, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.	Nat Commun, 2023, 14(1):5034 Nat Commun, 2023, 14(1):5034 Sci Rep, 2021, 11(1):19443
S2319	Limonin	Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.	Int J Biol Sci, 2019, 15(11):2497-2508 Biomed Pharmacother, 2019, 118:109366 Food Chem Toxicol, 2019, 125:621-628
S6625	Temsavir (BMS-626529)	Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses.	J Virol, 2023, 97(10):e0115423
S3494	Vicriviroc maleate	Vicriviroc maleate(SCH-417690 maleate,SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells.	Breast Cancer Res, 2021, 23(1):11
S6581	Fosamprenavir calcium salt	Fosamprenavir(GW433908G) is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections.	Antimicrob Agents Chemother, 2020, AAC.00872-20
S3287	Rosamultin	Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H₂O₂-induced oxidative damage and apoptosis.
S9010	Bevirimat	Bevirimat (MPC-4326, PA-457, YK-FH312), the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients.
S9625	Saquinavir (Ro 31-8959)	Saquinavir (Ro 31-8959,SAQ) is a potent and selective inhibitor of HIV proteinase with a mean IC50 of 2.7 nM in JM cells.
S6929	Dextran sulfate sodium (DSS)	Dextran sulfate sodium (DSS) is a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro that inhibits virus adsorption to the host cells.Dextran sulfate sodium (DSS) can be used to induce animal models of Enteritis, Ulcerative Colitis.
E0943	NBD-556	NBD-556 is a novel human immunodeficiency virus type 1 (HIV-1) entry inhibitor that block the gp120-CD4 interaction.
S9633	GS-6207	GS-6207 (Lenacapavir) is a HIV-1 capsid inhibitor. It shows anti-HIV activity with an EC50 of 0.1 nM in MT-4 cells.
E4466	Saquinavir Mesylate	Saquinavir mesylate (Ro 31-8959/003) is a potent inhibitor of HIV Protease used in antiretroviral therapy. It blocks proteolysis of polyproteins containing either wild-type or single-chain dimer retroviral proteinase (PR).
E1243	Azvudine	Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).
S1030	Panobinostat (LBH589)	Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.	Cancer Cell, 2025, 43(4):776-796.e14 Nat Commun, 2025, 16(1):2173 Nat Commun, 2025, 16(1):28
S6999	Chloroquine	Chloroquine is an antimalarial drug and autophagy/lysosome inhibitor. Chloroquine also suppresses Toll-like receptor-9 (TLR9) protein expression. Chloroquine is highly effective agianst SARS-CoV-2 (COVID-19) infection with EC50 of 1.13 μM in Vero E6 cells. Chloroquine has anti-HIV-1 activity.	Signal Transduct Target Ther, 2025, 10(1):26 Cell Discov, 2025, 11(1):15 Cell Metab, 2025, S1550-4131(25)00149-4
S1380	Lopinavir (ABT-378)	Lopinavir (ABT-378) is a potent HIV protease inhibitor with K_i of 1.3 pM in a cell-free assay.	Nat Commun, 2023, 14(1):5034 Nat Commun, 2023, 14(1):5034 Int J Mol Sci, 2023, 24(7)6062
S1185	Ritonavir	Ritonavir is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.	Vet Parasitol, 2025, 337:110471 Cell Chem Biol, 2024, S2451-9456(24)00396-9 Antiviral Res, 2024, 225:105840
S7381	Pepstatin A	Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.	Nat Commun, 2025, 16(1):4069 Cell Rep Med, 2024, 5(4):101503 Anim Nutr, 2024, 20:16:409-421.
S4282	Nelfinavir Mesylate	Nelfinavir Mesylate is a potent HIV protease inhibitor with K_i of 2 nM.	Int J Mol Sci, 2023, 24(7)6062 Int. J. Mol. Sci, 2023, 10.3390/ijms24076062 mBio, 2022, 13(1):e0304421
S1457	Atazanavir (BMS-232632) Sulfate	Atazanavir Sulfate (BMS-232632-05, Reyataz) is a HIV protease inhibitor with K_i of 2.66 nM in a cell-free assay.	bioRxiv, 2024, 2024.05.10.593637 J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y
S4662	Atazanavir	Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.	Int J Mol Sci, 2022, 23(23)15380 Chemistry, 2022, e202202798. Cells, 2021, 10(12)3458
S1620	Darunavir Ethanolate	Darunavir Ethanolate (TMC-114, UIC 94017) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.	J Virol, 2022, JVI0173021 J Cell Biochem, 2022, 10.1002/jcb.30213 Sci Rep, 2021, 11(1):19443
S5250	Darunavir	Darunavir (TMC114,DRV) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.	Front Cell Infect Microbiol, 2024, 14:1334126 PNAS Nexus, 2024, 3(1):pgad446 Antimicrob Agents Chemother, 2023, 67(7):e0046223
S9567	Indinavir Sulfate	Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.	Antimicrob Agents Chemother, 2023, 67(7):e0046223 J Cell Biochem, 2022, 10.1002/jcb.30213 Mol Metab, 2020, 29;101027
S1639	Amprenavir (VX-478)	Amprenavir (VX-478, 141W94, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.	Nat Commun, 2023, 14(1):5034 Nat Commun, 2023, 14(1):5034 Sci Rep, 2021, 11(1):19443
S2319	Limonin	Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.	Int J Biol Sci, 2019, 15(11):2497-2508 Biomed Pharmacother, 2019, 118:109366 Food Chem Toxicol, 2019, 125:621-628
S6625	Temsavir (BMS-626529)	Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses.	J Virol, 2023, 97(10):e0115423
S3494	Vicriviroc maleate	Vicriviroc maleate(SCH-417690 maleate,SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells.	Breast Cancer Res, 2021, 23(1):11
S6581	Fosamprenavir calcium salt	Fosamprenavir(GW433908G) is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections.	Antimicrob Agents Chemother, 2020, AAC.00872-20
S3287	Rosamultin	Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H₂O₂-induced oxidative damage and apoptosis.
S9010	Bevirimat	Bevirimat (MPC-4326, PA-457, YK-FH312), the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients.
S9625	Saquinavir (Ro 31-8959)	Saquinavir (Ro 31-8959,SAQ) is a potent and selective inhibitor of HIV proteinase with a mean IC50 of 2.7 nM in JM cells.
S6929	Dextran sulfate sodium (DSS)	Dextran sulfate sodium (DSS) is a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro that inhibits virus adsorption to the host cells.Dextran sulfate sodium (DSS) can be used to induce animal models of Enteritis, Ulcerative Colitis.
E0943	NBD-556	NBD-556 is a novel human immunodeficiency virus type 1 (HIV-1) entry inhibitor that block the gp120-CD4 interaction.
S9633	GS-6207	GS-6207 (Lenacapavir) is a HIV-1 capsid inhibitor. It shows anti-HIV activity with an EC50 of 0.1 nM in MT-4 cells.
E4466	Saquinavir Mesylate	Saquinavir mesylate (Ro 31-8959/003) is a potent inhibitor of HIV Protease used in antiretroviral therapy. It blocks proteolysis of polyproteins containing either wild-type or single-chain dimer retroviral proteinase (PR).
E1243	Azvudine	Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).

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