HIV Protease

Signaling Pathway Map

Research Area

Inhibitory Selectivity

HIV Protease Products

Catalog No. Information Product Use Citations Product Validations
S1030

Panobinostat (LBH589)

Panobinostat (LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.

S1185

Ritonavir

Ritonavir is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.

S1380

Lopinavir

Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay.

S3013

Plerixafor 8HCl (AMD3100 8HCl)

Plerixafor 8HCl (AMD3100 8HCl) is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent.

S1457

Atazanavir Sulfate

Atazanavir Sulfate is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.

S0076New

ABX464

ABX464 is a novel anti-HIV molecule that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from 5 different donors with IC50 ranging between 0.1 μM and 0.5 μM.

S6625New

Temsavir (BMS-626529)

Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses.

S6581New

Fosamprenavir calcium salt

Fosamprenavir is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections.

S1620

Darunavir Ethanolate

Darunavir Ethanolate (DRV) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

S1639

Amprenavir

Amprenavir is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.

S5250

Darunavir

Darunavir is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

S9010

Bevirimat

Bevirimat, the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients.

S2319

Limonin

Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.

S4662

Atazanavir

Atazanavir is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents.

S9567

Indinavir Sulfate

Indinavir sulfate is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.

S4282

Nelfinavir Mesylate

Nelfinavir Mesylate is a potent HIV protease inhibitor with Ki of 2 nM.

S7381

Pepstatin A

Pepstatin A is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.

Catalog No. Information Product Use Citations Product Validations
S1030

Panobinostat (LBH589)

Panobinostat (LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.

S1185

Ritonavir

Ritonavir is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.

S1380

Lopinavir

Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay.

S3013

Plerixafor 8HCl (AMD3100 8HCl)

Plerixafor 8HCl (AMD3100 8HCl) is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent.

S1457

Atazanavir Sulfate

Atazanavir Sulfate is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.

S0076New

ABX464

ABX464 is a novel anti-HIV molecule that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from 5 different donors with IC50 ranging between 0.1 μM and 0.5 μM.

S6625New

Temsavir (BMS-626529)

Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses.

S6581New

Fosamprenavir calcium salt

Fosamprenavir is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections.

S1620

Darunavir Ethanolate

Darunavir Ethanolate (DRV) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

S1639

Amprenavir

Amprenavir is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.

S5250

Darunavir

Darunavir is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

S9010

Bevirimat

Bevirimat, the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients.

S2319

Limonin

Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.

S4662

Atazanavir

Atazanavir is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents.

S9567

Indinavir Sulfate

Indinavir sulfate is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.

S4282

Nelfinavir Mesylate

Nelfinavir Mesylate is a potent HIV protease inhibitor with Ki of 2 nM.

S7381

Pepstatin A

Pepstatin A is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.