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HIV Protease

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HIV Protease Signaling Pathway Map

HIV Protease Products

All (22)
HIV Protease Inhibitors (22)
New HIV Protease Products

Catalog No.	Product Name	Information	Product Use Citations
E0943^New	NBD-556	NBD-556 is a novel human immunodeficiency virus type 1 (HIV-1) entry inhibitor that block the gp120-CD4 interaction.
E1243^New	Azvudine	Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).
S1030	Panobinostat (LBH589)	Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.	Cancer Cell, 2022, S1535-6108(22)00312-9 Signal Transduct Target Ther, 2022, 7(1):98 Blood, 2022, blood.2022016241
S1185	Ritonavir (ABT-538)	Ritonavir (ABT-538, A 84538, RTV, Norvir, Norvir Softgel) is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.	NPJ Digit Med, 2022, 5(1):83 Arch Toxicol, 2022, 96(7):2113-2122 Commun Biol, 2022, 5(1):154
S1380	Lopinavir (ABT-378)	Lopinavir (ABT-378) is a potent HIV protease inhibitor with K_i of 1.3 pM in a cell-free assay.	NPJ Digit Med, 2022, 5(1):83 PLoS Pathog, 2022, 18(6):e1010590 Pharmaceutics, 2022, 14(2)376
S1457	Atazanavir (BMS-232632) Sulfate	Atazanavir Sulfate (BMS-232632-05, Reyataz) is a HIV protease inhibitor with K_i of 2.66 nM in a cell-free assay.	Hum Cell, 2022, 10.1007/s13577-022-00671-y Sci Rep, 2021, 11(1):19443 Front Cardiovasc Med, 2021, 8:634774
S1620	Darunavir Ethanolate	Darunavir Ethanolate (TMC-114, UIC 94017) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.	J Virol, 2022, JVI0173021 J Cell Biochem, 2022, 10.1002/jcb.30213 Sci Rep, 2021, 11(1):19443
S1639	Amprenavir (VX-478)	Amprenavir (VX-478, 141W94, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.	Sci Rep, 2021, 11(1):19443 Antimicrob Agents Chemother, 2020, AAC.00872-20
S2319	Limonin	Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.	Int J Biol Sci, 2019, 15(11):2497-2508 Food Chem Toxicol, 2019, 125:621-628 Biomed Pharmacother, 2019, 118:109366
S3287	Rosamultin	Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H₂O₂-induced oxidative damage and apoptosis.
S3494	Vicriviroc maleate	Vicriviroc maleate(SCH-417690 maleate,SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells.	Breast Cancer Res, 2021, 23(1):11
S4282	Nelfinavir (AG 1343) Mesylate	Nelfinavir Mesylate (Viracept, AG1343) is a potent HIV protease inhibitor with K_i of 2 nM.	mBio, 2022, 13(1):e0304421 J Cell Biochem, 2022, 10.1002/jcb.30213 Pathogens, 2022, 11(6)707
S4662	Atazanavir	Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.	Sci Rep, 2021, 11(1):19443 Front Cardiovasc Med, 2021, 8:634774 ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
S5250	Darunavir	Darunavir (TMC114,DRV) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.	J Cell Biochem, 2022, 10.1002/jcb.30213 Sci Rep, 2021, 11(1):19443 ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
S6581	Fosamprenavir calcium salt	Fosamprenavir(GW433908G) is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections.	Antimicrob Agents Chemother, 2020, AAC.00872-20
S6625	Temsavir (BMS-626529)	Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses.
S6929	Dextran sulfate sodium (DSS)	Dextran sulfate sodium (DSS) is a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro that inhibits virus adsorption to the host cells.
S6999	Chloroquine (NSC-187208)	Chloroquine (NSC-187208, Aralen, CHQ, CQ) is an antimalarial drug and autophagy/lysosome inhibitor. Chloroquine also suppresses Toll-like receptor-9 (TLR9) protein expression. Chloroquine is highly effective agianst SARS-CoV-2 (COVID-19) infection with EC50 of 1.13 μM in Vero E6 cells. Chloroquine has anti-HIV-1 activity.	Bioact Mater, 2022, 18:459-470 Redox Biol, 2022, 52:102292 Cell Death Dis, 2022, 13(2):150
S7381	Pepstatin A	Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.	J Immunother Cancer, 2022, 10(3)e004129 PLoS Pathog, 2022, 18(1):e1010204 Mol Cell Biochem, 2022, 10.1007/s11010-022-04470-9
S9010	Bevirimat	Bevirimat (MPC-4326, PA-457, YK-FH312), the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients.
S9567	Indinavir Sulfate	Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.	J Cell Biochem, 2022, 10.1002/jcb.30213 Mol Metab, 2020, 29;101027 Antimicrob Agents Chemother, 2020, AAC.00872-20
S9625^New	Saquinavir (Ro 31-8959)	Saquinavir (Ro 31-8959,SAQ) is a potent and selective inhibitor of HIV proteinase with a mean IC50 of 2.7 nM in JM cells.
E0943^New	NBD-556	NBD-556 is a novel human immunodeficiency virus type 1 (HIV-1) entry inhibitor that block the gp120-CD4 interaction.
E1243^New	Azvudine	Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).
S1030	Panobinostat (LBH589)	Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.	Cancer Cell, 2022, S1535-6108(22)00312-9 Signal Transduct Target Ther, 2022, 7(1):98 Blood, 2022, blood.2022016241
S1185	Ritonavir (ABT-538)	Ritonavir (ABT-538, A 84538, RTV, Norvir, Norvir Softgel) is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.	NPJ Digit Med, 2022, 5(1):83 Arch Toxicol, 2022, 96(7):2113-2122 Commun Biol, 2022, 5(1):154
S1380	Lopinavir (ABT-378)	Lopinavir (ABT-378) is a potent HIV protease inhibitor with K_i of 1.3 pM in a cell-free assay.	NPJ Digit Med, 2022, 5(1):83 PLoS Pathog, 2022, 18(6):e1010590 Pharmaceutics, 2022, 14(2)376
S1457	Atazanavir (BMS-232632) Sulfate	Atazanavir Sulfate (BMS-232632-05, Reyataz) is a HIV protease inhibitor with K_i of 2.66 nM in a cell-free assay.	Hum Cell, 2022, 10.1007/s13577-022-00671-y Sci Rep, 2021, 11(1):19443 Front Cardiovasc Med, 2021, 8:634774
S1620	Darunavir Ethanolate	Darunavir Ethanolate (TMC-114, UIC 94017) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.	J Virol, 2022, JVI0173021 J Cell Biochem, 2022, 10.1002/jcb.30213 Sci Rep, 2021, 11(1):19443
S1639	Amprenavir (VX-478)	Amprenavir (VX-478, 141W94, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.	Sci Rep, 2021, 11(1):19443 Antimicrob Agents Chemother, 2020, AAC.00872-20
S2319	Limonin	Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.	Int J Biol Sci, 2019, 15(11):2497-2508 Food Chem Toxicol, 2019, 125:621-628 Biomed Pharmacother, 2019, 118:109366
S3287	Rosamultin	Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H₂O₂-induced oxidative damage and apoptosis.
S3494	Vicriviroc maleate	Vicriviroc maleate(SCH-417690 maleate,SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells.	Breast Cancer Res, 2021, 23(1):11
S4282	Nelfinavir (AG 1343) Mesylate	Nelfinavir Mesylate (Viracept, AG1343) is a potent HIV protease inhibitor with K_i of 2 nM.	mBio, 2022, 13(1):e0304421 J Cell Biochem, 2022, 10.1002/jcb.30213 Pathogens, 2022, 11(6)707
S4662	Atazanavir	Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.	Sci Rep, 2021, 11(1):19443 Front Cardiovasc Med, 2021, 8:634774 ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
S5250	Darunavir	Darunavir (TMC114,DRV) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.	J Cell Biochem, 2022, 10.1002/jcb.30213 Sci Rep, 2021, 11(1):19443 ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
S6581	Fosamprenavir calcium salt	Fosamprenavir(GW433908G) is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections.	Antimicrob Agents Chemother, 2020, AAC.00872-20
S6625	Temsavir (BMS-626529)	Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses.
S6929	Dextran sulfate sodium (DSS)	Dextran sulfate sodium (DSS) is a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro that inhibits virus adsorption to the host cells.
S6999	Chloroquine (NSC-187208)	Chloroquine (NSC-187208, Aralen, CHQ, CQ) is an antimalarial drug and autophagy/lysosome inhibitor. Chloroquine also suppresses Toll-like receptor-9 (TLR9) protein expression. Chloroquine is highly effective agianst SARS-CoV-2 (COVID-19) infection with EC50 of 1.13 μM in Vero E6 cells. Chloroquine has anti-HIV-1 activity.	Bioact Mater, 2022, 18:459-470 Redox Biol, 2022, 52:102292 Cell Death Dis, 2022, 13(2):150
S7381	Pepstatin A	Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.	J Immunother Cancer, 2022, 10(3)e004129 PLoS Pathog, 2022, 18(1):e1010204 Mol Cell Biochem, 2022, 10.1007/s11010-022-04470-9
S9010	Bevirimat	Bevirimat (MPC-4326, PA-457, YK-FH312), the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients.
S9567	Indinavir Sulfate	Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.	J Cell Biochem, 2022, 10.1002/jcb.30213 Mol Metab, 2020, 29;101027 Antimicrob Agents Chemother, 2020, AAC.00872-20
S9625^New	Saquinavir (Ro 31-8959)	Saquinavir (Ro 31-8959,SAQ) is a potent and selective inhibitor of HIV proteinase with a mean IC50 of 2.7 nM in JM cells.
E0943^New	NBD-556	NBD-556 is a novel human immunodeficiency virus type 1 (HIV-1) entry inhibitor that block the gp120-CD4 interaction.
E1243^New	Azvudine	Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).
S9625^New	Saquinavir (Ro 31-8959)	Saquinavir (Ro 31-8959,SAQ) is a potent and selective inhibitor of HIV proteinase with a mean IC50 of 2.7 nM in JM cells.