S1030 |
Panobinostat (LBH589)
|
Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3. |
-
Signal Transduct Target Ther, 2022, 7(1):98
-
Blood, 2022, blood.2022016241
-
Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7
|
|
S1185 |
Ritonavir (ABT-538)
|
Ritonavir (ABT-538, A 84538, RTV, Norvir, Norvir Softgel) is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis. |
-
Arch Toxicol, 2022, 96(7):2113-2122
-
Commun Biol, 2022, 5(1):154
-
J Virol, 2022, JVI0173021
|
|
S1380 |
Lopinavir (ABT-378)
|
Lopinavir (ABT-378) is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay. |
-
Pharmaceutics, 2022, 14(2)376
-
Commun Biol, 2022, 5(1):154
-
J Cell Biochem, 2022, 10.1002/jcb.30213
|
|
S1457 |
Atazanavir (BMS-232632) Sulfate
|
Atazanavir Sulfate (BMS-232632) is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay. |
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
Sci Rep, 2021, 11(1):19443
-
Front Cardiovasc Med, 2021, 8:634774
|
|
S1620 |
Darunavir Ethanolate
|
Darunavir Ethanolate (TMC-114, UIC 94017) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection. |
-
J Virol, 2022, JVI0173021
-
J Cell Biochem, 2022, 10.1002/jcb.30213
-
Sci Rep, 2021, 11(1):19443
|
|
S1639 |
Amprenavir (VX-478)
|
Amprenavir (VX-478, 141W94, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV. |
-
Sci Rep, 2021, 11(1):19443
-
Antimicrob Agents Chemother, 2020, AAC.00872-20
|
|
S2319 |
Limonin
|
Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability. |
-
Int J Biol Sci, 2019, 15(11):2497-2508
-
Food Chem Toxicol, 2019, 125:621-628
-
Biomed Pharmacother, 2019, 118:109366
|
|
S3287 |
Rosamultin
|
Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H2O2-induced oxidative damage and apoptosis. |
|
|
S4282 |
Nelfinavir (AG 1343) Mesylate
|
Nelfinavir Mesylate (Viracept, AG1343) is a potent HIV protease inhibitor with Ki of 2 nM.
|
-
mBio, 2022, 13(1):e0304421
-
J Cell Biochem, 2022, 10.1002/jcb.30213
-
Cell Rep, 2021, 35(10):109218
|
|
S4662 |
Atazanavir
|
Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein. |
-
Sci Rep, 2021, 11(1):19443
-
Front Cardiovasc Med, 2021, 8:634774
-
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
|
|
S5250 |
Darunavir
|
Darunavir (TMC114) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection. |
-
J Cell Biochem, 2022, 10.1002/jcb.30213
-
Sci Rep, 2021, 11(1):19443
-
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
|
|
S6581 |
Fosamprenavir calcium salt
|
Fosamprenavir is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections. |
-
Antimicrob Agents Chemother, 2020, AAC.00872-20
|
|
S6625 |
Temsavir (BMS-626529)
|
Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses. |
|
|
S6929 |
Dextran sulfate sodium (DSS)
|
Dextran sulfate sodium (DSS) is a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro that inhibits virus adsorption to the host cells. |
|
|
S6999 |
Chloroquine (NSC-187208)
|
Chloroquine (NSC-187208, Aralen, CHQ, CQ) is an antimalarial drug and autophagy/lysosome inhibitor. Chloroquine also suppresses Toll-like receptor-9 (TLR9) protein expression. Chloroquine is highly effective agianst SARS-CoV-2 (COVID-19) infection with EC50 of 1.13 μM in Vero E6 cells. Chloroquine has anti-HIV-1 activity. |
-
Bioact Mater, 2022, 18:459-470
-
Redox Biol, 2022, 52:102292
-
Cell Death Dis, 2022, 13(2):150
|
|
S7381 |
Pepstatin A
|
Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases. |
-
J Immunother Cancer, 2022, 10(3)e004129
-
PLoS Pathog, 2022, 18(1):e1010204
-
Pharmacol Res, 2021, S1043-6618(21)00517-X
|
|
S9010 |
Bevirimat
|
Bevirimat (MPC-4326, PA-457, YK-FH312), the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients. |
|
|
S9567 |
Indinavir Sulfate
|
Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS. |
-
J Cell Biochem, 2022, 10.1002/jcb.30213
-
Mol Metab, 2020, 29;101027
-
Antimicrob Agents Chemother, 2020, AAC.00872-20
|
|
S9625New |
Saquinavir (Ro 31-8959)
|
Saquinavir (Ro 31-8959) is a potent and selective inhibitor of HIV proteinase with a mean IC50 of 2.7 nM in JM cells. |
|
|
S1030 |
Panobinostat (LBH589)
|
Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3. |
- Signal Transduct Target Ther, 2022, 7(1):98
- Blood, 2022, blood.2022016241
- Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7
|
|
S1185 |
Ritonavir (ABT-538)
|
Ritonavir (ABT-538, A 84538, RTV, Norvir, Norvir Softgel) is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis. |
- Arch Toxicol, 2022, 96(7):2113-2122
- Commun Biol, 2022, 5(1):154
- J Virol, 2022, JVI0173021
|
|
S1380 |
Lopinavir (ABT-378)
|
Lopinavir (ABT-378) is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay. |
- Pharmaceutics, 2022, 14(2)376
- Commun Biol, 2022, 5(1):154
- J Cell Biochem, 2022, 10.1002/jcb.30213
|
|
S1457 |
Atazanavir (BMS-232632) Sulfate
|
Atazanavir Sulfate (BMS-232632) is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay. |
- Hum Cell, 2022, 10.1007/s13577-022-00671-y
- Sci Rep, 2021, 11(1):19443
- Front Cardiovasc Med, 2021, 8:634774
|
|
S1620 |
Darunavir Ethanolate
|
Darunavir Ethanolate (TMC-114, UIC 94017) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection. |
- J Virol, 2022, JVI0173021
- J Cell Biochem, 2022, 10.1002/jcb.30213
- Sci Rep, 2021, 11(1):19443
|
|
S1639 |
Amprenavir (VX-478)
|
Amprenavir (VX-478, 141W94, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV. |
- Sci Rep, 2021, 11(1):19443
- Antimicrob Agents Chemother, 2020, AAC.00872-20
|
|
S2319 |
Limonin
|
Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability. |
- Int J Biol Sci, 2019, 15(11):2497-2508
- Food Chem Toxicol, 2019, 125:621-628
- Biomed Pharmacother, 2019, 118:109366
|
|
S3287 |
Rosamultin
|
Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H2O2-induced oxidative damage and apoptosis. |
|
|
S4282 |
Nelfinavir (AG 1343) Mesylate
|
Nelfinavir Mesylate (Viracept, AG1343) is a potent HIV protease inhibitor with Ki of 2 nM.
|
- mBio, 2022, 13(1):e0304421
- J Cell Biochem, 2022, 10.1002/jcb.30213
- Cell Rep, 2021, 35(10):109218
|
|
S4662 |
Atazanavir
|
Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein. |
- Sci Rep, 2021, 11(1):19443
- Front Cardiovasc Med, 2021, 8:634774
- ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
|
|
S5250 |
Darunavir
|
Darunavir (TMC114) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection. |
- J Cell Biochem, 2022, 10.1002/jcb.30213
- Sci Rep, 2021, 11(1):19443
- ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
|
|
S6581 |
Fosamprenavir calcium salt
|
Fosamprenavir is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections. |
- Antimicrob Agents Chemother, 2020, AAC.00872-20
|
|
S6625 |
Temsavir (BMS-626529)
|
Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses. |
|
|
S6929 |
Dextran sulfate sodium (DSS)
|
Dextran sulfate sodium (DSS) is a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro that inhibits virus adsorption to the host cells. |
|
|
S6999 |
Chloroquine (NSC-187208)
|
Chloroquine (NSC-187208, Aralen, CHQ, CQ) is an antimalarial drug and autophagy/lysosome inhibitor. Chloroquine also suppresses Toll-like receptor-9 (TLR9) protein expression. Chloroquine is highly effective agianst SARS-CoV-2 (COVID-19) infection with EC50 of 1.13 μM in Vero E6 cells. Chloroquine has anti-HIV-1 activity. |
- Bioact Mater, 2022, 18:459-470
- Redox Biol, 2022, 52:102292
- Cell Death Dis, 2022, 13(2):150
|
|
S7381 |
Pepstatin A
|
Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases. |
- J Immunother Cancer, 2022, 10(3)e004129
- PLoS Pathog, 2022, 18(1):e1010204
- Pharmacol Res, 2021, S1043-6618(21)00517-X
|
|
S9010 |
Bevirimat
|
Bevirimat (MPC-4326, PA-457, YK-FH312), the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients. |
|
|
S9567 |
Indinavir Sulfate
|
Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS. |
- J Cell Biochem, 2022, 10.1002/jcb.30213
- Mol Metab, 2020, 29;101027
- Antimicrob Agents Chemother, 2020, AAC.00872-20
|
|
S9625New |
Saquinavir (Ro 31-8959)
|
Saquinavir (Ro 31-8959) is a potent and selective inhibitor of HIV proteinase with a mean IC50 of 2.7 nM in JM cells. |
|
|