Home Proteases HIV Protease

HIV Protease

Other Proteases Related Inhibitors

Proteasome HCV Protease Thrombin MMP Cysteine Protease Serine Protease Tyrosinase Glutaminase PAD Neprilysin

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S1030 Panobinostat (LBH589) Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. It induces autophagy and apoptosis, and effectively disrupts HIV latency in vivo. Phase 3.
Cancer Cell, 2025, 43(4):776-796.e14
Signal Transduct Target Ther, 2025, 10(1):230
Nat Commun, 2025, 16(1):2173
Verified customer review of Panobinostat (LBH589)
S1185 Ritonavir Ritonavir is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. This compound induces apoptosis.
Nature, 2025, 10.1038/s41586-025-09755-9
Vet Parasitol, 2025, 337:110471
Cell Chem Biol, 2024, S2451-9456(24)00396-9
Verified customer review of Ritonavir
S1380 Lopinavir (ABT-378) Lopinavir (ABT-378) is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay.
J Microbiol Biotechnol, 2025, 35:e2411063
Nat Commun, 2023, 14(1):5034
Int J Mol Sci, 2023, 24(7)6062
Verified customer review of Lopinavir (ABT-378)
S7381 Pepstatin A Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.
Nat Commun, 2025, 16(1):4069
Autophagy, 2025, 21(11):2473-2496
J Exp Clin Cancer Res, 2025, 44(1):317
S4282 Nelfinavir Mesylate Nelfinavir Mesylate is a potent HIV protease inhibitor with Ki of 2 nM.
Biochem Biophys Rep, 2025, 42:101987
Int J Mol Sci, 2023, 24(7)6062
Int. J. Mol. Sci, 2023, 10.3390/ijms24076062
S1457 Atazanavir (BMS-232632) Sulfate Atazanavir Sulfate (BMS-232632-05, Reyataz) is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.
bioRxiv, 2024, 2024.05.10.593637
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Verified customer review of Atazanavir (BMS-232632) Sulfate
S5250 Darunavir Darunavir (TMC114,DRV) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.
Front Cell Infect Microbiol, 2024, 14:1334126
PNAS Nexus, 2024, 3(1):pgad446
Antimicrob Agents Chemother, 2023, 67(7):e0046223
S4662 Atazanavir Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. This compound is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.
Int J Mol Sci, 2022, 23(23)15380
Chemistry, 2022, e202202798.
Cells, 2021, 10(12)3458
S1620 Darunavir Ethanolate Darunavir Ethanolate (TMC-114, UIC 94017) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.
J Virol, 2022, JVI0173021
J Cell Biochem, 2022, 10.1002/jcb.30213
Sci Rep, 2021, 11(1):19443
Verified customer review of Darunavir Ethanolate
S9567 Indinavir Sulfate Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.
Antimicrob Agents Chemother, 2023, 67(7):e0046223
J Cell Biochem, 2022, 10.1002/jcb.30213
Mol Metab, 2020, 29;101027

Signaling Pathway Map