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Neprilysin

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Cat.No. Product Name Information Product Use Citations Product Validations
S7678 Sacubitril/valsartan (LCZ696) Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.
Oxidative Medicine and Cellular Longevity, September 22, 2022, 5009289
Front Pharmacol, 2025, 16:1539032
J Immunother Cancer, 2024, 12(11)e009805
Verified customer review of Sacubitril/valsartan (LCZ696)
E7186 Sacubitril Sacubitril is a potent and orally active inhibitor of NEP (neprilysin) with an IC50 of 5 nM. It exhibits the potential to treat chronic heart failure with reduced ejection fraction.
World J Gastroenterol, 2025, 31(33):109562
World Journal of Gastroenterology, 2025, 109562
S3388 Sacubitrilat Sacubitrilat (Sac, LBQ-657) is an active inhibitor of neprilysin (NEP).
E4454 DL-Thiorphan Thiorphan (DL-3-Mercapto-2-benzylpropanoylglycine) is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM. It is also a potent inhibitor of enkephalinase, with antinociceptive activity.
S4426 Sacubitril hemicalcium salt Sacubitril (AHU-377) hemicalcium salt, a component of the heart failure medicine LCZ696, is a potent inhibitor of neprilysin (neutral endopeptidase, NEP).