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PCSK9

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR
Cat.No. Product Name Information Product Use Citations Product Validations
S7976 SBC-115076 SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.
Cancers (Basel), 2024, 16(4)713
Front Med (Lausanne), 2024, 11:1284199
Front Med (Lausanne), 2024, 11:1509168
E4629New AZD0780 AZD0780 (Laroprovstat, Pcsk9-IN-12) is an orally potent inhibitor of PCSK9 with a Kd value of <200 nM. It directly binds to PCSK9, blocks its function, and significantly reduces LDL cholesterol levels, making it useful for dyslipidemia research.
S8420 R-IMPP R-IMPP is an inhibitor of PCSK9 secretion, half maximal inhibitory concentration [IC50] = 4.8 μM.
S0118 SBC-110736 SBC-110736 is an inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9) that lowers cholesterol levels in mice.
E0116 PF-06446846 hydrochloride PF-06446846 (PF846) Hydrochloride is an orally bioavailable and specific inhibitor of PCSK9 with an IC50 of 0.3 µM in Huh7 cells.
S0849 PF-06446846 PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. This compound selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region.