- Inhibitory Selectivity
|Catalog No.||Product Name||Solubility(25°C)|
|S1386||Nafamostat Mesylate||53 mg/mL||20 mg/mL||<1 mg/mL|
|S3025||PMSF||<1 mg/mL||35 mg/mL||15 mg/mL|
|S2101||Gabexate Mesylate||12 mg/mL||83 mg/mL||83 mg/mL|
|S7218||Alvelestat (AZD9668)||<1 mg/mL||100 mg/mL||<1 mg/mL|
|S7378||AEBSF HCl||20 mg/mL||47 mg/mL||47 mg/mL|
|S7380||Leupeptin Hemisulfate||95 mg/mL||95 mg/mL||95 mg/mL|
|S8457||UK-371804 HCl||<1 mg/mL||30 mg/mL||<1 mg/mL|
|S4666||Sivelestat sodium tetrahydrate||<1 mg/mL||100 mg/mL||100 mg/mL|
|S8136||Sivelestat (ONO-5046)||<1 mg/mL||86 mg/mL||86 mg/mL|
|S7377||Aprotinin||100 mg/mL||-1 mg/mL||-1 mg/mL|
- Serine Protease Inhibitors (10)
|Catalog No.||Information||Product Use Citations||Product Validations|
Nafamostat mesilate is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis.
Immunofluorescence of NF-κB/p65 in HCT 116 and SW 1116 cells exposed to TNFα (25 ng/ml) with or without nafamostat mesilate(FLU) (100 μM). Scale bars: 20 μm.
PMSF is an irreversible serine/cysteine protease inhibitor.
Gabexate Mesylate is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation.
Carfilzomib inhibits cell viability of several glioblastoma cell lines: a U87MG (i), U87-EGFRvIII (ii) and LN229 (iii) glioblastoma cells were seeded into 96-well plates in triplicate and following overnight incubation were treated with 10 µM of bortezomib, carfilzomib, nafamostat mesylate (NM), gabexate mesylate (GM) or acetylsalicylic acid (AA; Aspirin) for 72 h to assess their effect on cell viability.
Alvelestat (AZD9668) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. Phase 2.
AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.
Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.
Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. It almost shows no activity at a range of other proteases.
Aprotinin is a small protein serine protease inhibitor (Kd=0.06 pM for bovine β-trypsin), used to reduce perioperative blood loss and transfusion.