Serine Protease

Serine Protease Products

  • All (16)
  • Serine Protease Inhibitors (16)
  • New Serine Protease Products
Catalog No. Product Name Information Product Use Citations Product Validations
S7380 Leupeptin Hemisulfate Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.
Nat Commun, 2023, 14(1):4066
Acta Pharm Sin B, 2022, 12(6):2869-2886
Theranostics, 2022, 12(14):6395-6408
S3025 PMSF PMSF (Phenylmethylsulfonyl Fluoride, Benzylsulfonyl fluoride) is an irreversible serine/cysteine protease inhibitor.
Cell Biosci, 2023, 13(1):9
Cell Mol Immunol, 2022, 19(10):1153-1167
EMBO J, 2022, 10.15252/embj.2021109102
S1811 Amiloride HCl Amiloride HCl is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).
Virus Res, 2024, 339:199258
J Clin Invest, 2023, 10.1172/JCI163402
J Clin Invest, 2023, 133(19)e163402
S1386 Nafamostat mesilate (FUT-175) Nafamostat mesilate is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis. Nafamostat mesylate blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19. Nafamostat Mesilate attenuates inflammation and apoptosis.
Cell Death Dis, 2024, 15(2):109
Pathogens, 2023, 13(1)18
Nat Commun, 2022, 13(1):4804
S8136 Sivelestat Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. It almost shows no activity at a range of other proteases.
Cell Mol Gastroenterol Hepatol, 2022, S2352-345X(22)00097-2
Microb Pathog, 2022, 166:105558
Neuroscience, 2022, 503:45-57
S7378 AEBSF HCl AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.
Int J Biol Sci, 2023, 19(13):4327-4339
Int J Biol Sci, 2023, 19(13):4327-4339
Front Cell Infect Microbiol, 2023, 13:1136056
S4666 Sivelestat sodium tetrahydrate Sivelestat sodium tetrahydrate (ONO5046-Na, EI546, LY544349) is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.
J Immunol, 2021, 206(4):797-806
Aging (Albany NY), 2020, 12(17):16820-16836
Front Microbiol, 2020, 10:2936
S2101 Gabexate Mesylate Gabexate Mesylate(FOY) is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation.
Front Oncol, 2019, 0.87569444444
J Biol Chem, 2018, 293(34):13112-13124
Invest Ophthalmol Vis Sci, 2016, 57(14):6461-6473
S7218 Alvelestat (AZD9668) Alvelestat (AZD9668, Avelestat) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. Phase 2.
Proc Natl Acad Sci U S A, 2021, 118(34)e2102435118
Sci Rep, 2019, 9(1):715
Exp Cell Res, 2019, 382(2):111486
S8457 UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
PNAS Nexus, 2022, 1(3):pgac104
Front Genet, 2021, 12:651882
S7377 Aprotinin Aprotinin is a small protein serine protease inhibitor (Kd=0.06 pM for bovine β-trypsin), used to reduce perioperative blood loss and transfusion.
Elife, 2021, 10e65962
Autophagy, 2017, 13(3):538-553
S0042 Fulacimstat Fulacimstat (BAY1142524) is an orally available inhibitor of chymase with IC50 of 4 nM and 3 nM for human and hamster chymase enzyme, respectively.
S3511 FOY251 FOY251, an active metabolite of camostat mesilate, is an inhibitor of synthetic serine protease. FOY251 inhibits SARS-CoV-2 infection.
E1342New Sebetralstat Sebetralstat(KVD900) is a plasma kallikrien inhibitor.
E1014 Upamostat (WX-671) Upamostat (WX-671), a novel serine protease urokinase (uPA) inhibitor by inhibiting the urokinase-type plasminogen activator (uPA) system.
S0479 ZK824859 ZK824859 is a potent, selective and orally bioavailable inhibitor of urokinase plasminogen activator (uPA) with IC50 of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.
S7380 Leupeptin Hemisulfate Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.
Nat Commun, 2023, 14(1):4066
Acta Pharm Sin B, 2022, 12(6):2869-2886
Theranostics, 2022, 12(14):6395-6408
S3025 PMSF PMSF (Phenylmethylsulfonyl Fluoride, Benzylsulfonyl fluoride) is an irreversible serine/cysteine protease inhibitor.
Cell Biosci, 2023, 13(1):9
Cell Mol Immunol, 2022, 19(10):1153-1167
EMBO J, 2022, 10.15252/embj.2021109102
S1811 Amiloride HCl Amiloride HCl is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).
Virus Res, 2024, 339:199258
J Clin Invest, 2023, 10.1172/JCI163402
J Clin Invest, 2023, 133(19)e163402
S1386 Nafamostat mesilate (FUT-175) Nafamostat mesilate is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis. Nafamostat mesylate blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19. Nafamostat Mesilate attenuates inflammation and apoptosis.
Cell Death Dis, 2024, 15(2):109
Pathogens, 2023, 13(1)18
Nat Commun, 2022, 13(1):4804
S8136 Sivelestat Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. It almost shows no activity at a range of other proteases.
Cell Mol Gastroenterol Hepatol, 2022, S2352-345X(22)00097-2
Microb Pathog, 2022, 166:105558
Neuroscience, 2022, 503:45-57
S7378 AEBSF HCl AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.
Int J Biol Sci, 2023, 19(13):4327-4339
Int J Biol Sci, 2023, 19(13):4327-4339
Front Cell Infect Microbiol, 2023, 13:1136056
S4666 Sivelestat sodium tetrahydrate Sivelestat sodium tetrahydrate (ONO5046-Na, EI546, LY544349) is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.
J Immunol, 2021, 206(4):797-806
Aging (Albany NY), 2020, 12(17):16820-16836
Front Microbiol, 2020, 10:2936
S2101 Gabexate Mesylate Gabexate Mesylate(FOY) is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation.
Front Oncol, 2019, 0.87569444444
J Biol Chem, 2018, 293(34):13112-13124
Invest Ophthalmol Vis Sci, 2016, 57(14):6461-6473
S7218 Alvelestat (AZD9668) Alvelestat (AZD9668, Avelestat) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. Phase 2.
Proc Natl Acad Sci U S A, 2021, 118(34)e2102435118
Sci Rep, 2019, 9(1):715
Exp Cell Res, 2019, 382(2):111486
S8457 UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
PNAS Nexus, 2022, 1(3):pgac104
Front Genet, 2021, 12:651882
S7377 Aprotinin Aprotinin is a small protein serine protease inhibitor (Kd=0.06 pM for bovine β-trypsin), used to reduce perioperative blood loss and transfusion.
Elife, 2021, 10e65962
Autophagy, 2017, 13(3):538-553
S0042 Fulacimstat Fulacimstat (BAY1142524) is an orally available inhibitor of chymase with IC50 of 4 nM and 3 nM for human and hamster chymase enzyme, respectively.
S3511 FOY251 FOY251, an active metabolite of camostat mesilate, is an inhibitor of synthetic serine protease. FOY251 inhibits SARS-CoV-2 infection.
E1342New Sebetralstat Sebetralstat(KVD900) is a plasma kallikrien inhibitor.
E1014 Upamostat (WX-671) Upamostat (WX-671), a novel serine protease urokinase (uPA) inhibitor by inhibiting the urokinase-type plasminogen activator (uPA) system.
S0479 ZK824859 ZK824859 is a potent, selective and orally bioavailable inhibitor of urokinase plasminogen activator (uPA) with IC50 of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.
E1342New Sebetralstat Sebetralstat(KVD900) is a plasma kallikrien inhibitor.

Choose Selective Serine Protease Inhibitors

Tags: Serine Protease inhibitor|Serine Protease agonist|Serine Protease activator|Serine Protease inducer|Serine Protease antagonist|Serine Protease signaling pathway|Serine Protease assay kit