Serine Protease

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Serine Protease Products

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  • Serine Protease Inhibitors (18)
  • New Serine Protease Products
Catalog No. Product Name Information Product Use Citations Product Validations
S7380 Leupeptin Hemisulfate Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.
Adv Mater, 2025, e18445.
Nat Commun, 2025, 16(1):4069
J Adv Res, 2025, S2090-1232(25)00056-6
S3025 PMSF PMSF (Phenylmethylsulfonyl Fluoride, Benzylsulfonyl fluoride) is an irreversible serine/cysteine protease inhibitor.
Cell Death Discov, 2024, 10(1):171
Cell Biosci, 2023, 13(1):9
Cell Biosci, 2023, 13(1):9
S1811 Amiloride HCl Amiloride HCl is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).
J Extracell Vesicles, 2024, 13(4):e12426
J Extracell Vesicles, 2024, 13(4):e12426
Virus Res, 2024, 339:199258
S1386 Nafamostat mesilate (FUT-175) Nafamostat mesilate is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis. Nafamostat mesylate blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19. Nafamostat Mesilate attenuates inflammation and apoptosis.
J Immunother Cancer, 2024, 12(11)e009805
Cell Death Dis, 2024, 15(2):109
CNS Neurosci Ther, 2024, 30(6):e14822
Verified customer review of Nafamostat mesilate (FUT-175)
S8136 Sivelestat Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. It almost shows no activity at a range of other proteases.
Redox Biol, 2025, 87:103881
J Immunother Cancer, 2025, 13(2)e010813
Int Immunopharmacol, 2025, 151:114340
S7378 AEBSF HCl AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.
Acta Pharm Sin B, 2024, 14(6):2554-2566
Int J Med Sci, 2024, 21(7):1204-1212
Int J Biol Sci, 2023, 19(13):4327-4339
S4666 Sivelestat sodium tetrahydrate Sivelestat sodium tetrahydrate (ONO5046-Na, EI546, LY544349) is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.
J Thorac Dis, 2024, 16(10):6616-6633
J Immunol, 2021, 206(4):797-806
Aging (Albany NY), 2020, 12(17):16820-16836
S2101 Gabexate Mesylate Gabexate Mesylate(FOY) is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation.
iScience, 2024, 27(10):110862
Curr Res Chem Biol, 2022, 2:100023
Front Oncol, 2019, 0.87569444444
Verified customer review of Gabexate Mesylate
S7218 Alvelestat (AZD9668) Alvelestat (AZD9668, Avelestat) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. Phase 2.
Cell Death Discov, 2025, 11(1):29
Int Immunopharmacol, 2025, 159:114860
Proc Natl Acad Sci U S A, 2021, 118(34)e2102435118
S8457 UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
PNAS Nexus, 2022, 1(3):pgac104
Front Genet, 2021, 12:651882
S7377 Aprotinin Aprotinin is a small protein serine protease inhibitor (Kd=0.06 pM for bovine β-trypsin), used to reduce perioperative blood loss and transfusion.
Front Cell Neurosci, 2025, 19:1623747
J Immunother Cancer, 2024, 12(11)e009805
Elife, 2021, 10e65962
E7249New Ulinastatin Ulinastatin (Uristatin) is the main inhibitor of a hydrolase protein and serine protease suppresses trypsin, chymotrypsin, and other pancreatic proteases. It can inhibit the production and release of inflammatory factors through mediating inflammatory pathways, while modulating apoptosis, enzyme activity, coagulation, and immune responses. It is effective in preventing and managing conditions like pancreatitis, cerebral edema, acute respiratory distress, circulatory failure, sepsis, and systemic inflammatory response syndrome.
S0042 Fulacimstat Fulacimstat (BAY1142524) is an orally available inhibitor of chymase with IC50 of 4 nM and 3 nM for human and hamster chymase enzyme, respectively.
S3511 FOY251 FOY251, an active metabolite of camostat mesilate, is an inhibitor of synthetic serine protease. FOY251 inhibits SARS-CoV-2 infection.
E1342 Sebetralstat Sebetralstat(KVD900) is a plasma kallikrien inhibitor.
E6013New Sivelestat sodium Sivelestat sodium (ONO-5046, Sodium sivelestat, LY544349 sodium) is a potent, specific, and intravenously active inhibitor of neutrophil elastase with an IC50 value of 44 nm. It is a useful agent for studying the roles of neutrophil elastase in animal disease models such as emphysema, adult respiratory distress syndrome, septic shock and disseminated intravascular coagulation in COVID-19.
E1014 Upamostat (WX-671) Upamostat (WX-671), a novel serine protease urokinase (uPA) inhibitor by inhibiting the urokinase-type plasminogen activator (uPA) system.
S0479 ZK824859 ZK824859 is a potent, selective and orally bioavailable inhibitor of urokinase plasminogen activator (uPA) with IC50 of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.
S7380 Leupeptin Hemisulfate Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.
Adv Mater, 2025, e18445.
Nat Commun, 2025, 16(1):4069
J Adv Res, 2025, S2090-1232(25)00056-6
S3025 PMSF PMSF (Phenylmethylsulfonyl Fluoride, Benzylsulfonyl fluoride) is an irreversible serine/cysteine protease inhibitor.
Cell Death Discov, 2024, 10(1):171
Cell Biosci, 2023, 13(1):9
Cell Biosci, 2023, 13(1):9
S1811 Amiloride HCl Amiloride HCl is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).
J Extracell Vesicles, 2024, 13(4):e12426
J Extracell Vesicles, 2024, 13(4):e12426
Virus Res, 2024, 339:199258
S1386 Nafamostat mesilate (FUT-175) Nafamostat mesilate is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis. Nafamostat mesylate blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19. Nafamostat Mesilate attenuates inflammation and apoptosis.
J Immunother Cancer, 2024, 12(11)e009805
Cell Death Dis, 2024, 15(2):109
CNS Neurosci Ther, 2024, 30(6):e14822
 Verified customer review of Nafamostat mesilate (FUT-175)
S8136 Sivelestat Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. It almost shows no activity at a range of other proteases.
Redox Biol, 2025, 87:103881
J Immunother Cancer, 2025, 13(2)e010813
Int Immunopharmacol, 2025, 151:114340
S7378 AEBSF HCl AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.
Acta Pharm Sin B, 2024, 14(6):2554-2566
Int J Med Sci, 2024, 21(7):1204-1212
Int J Biol Sci, 2023, 19(13):4327-4339
S4666 Sivelestat sodium tetrahydrate Sivelestat sodium tetrahydrate (ONO5046-Na, EI546, LY544349) is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.
J Thorac Dis, 2024, 16(10):6616-6633
J Immunol, 2021, 206(4):797-806
Aging (Albany NY), 2020, 12(17):16820-16836
S2101 Gabexate Mesylate Gabexate Mesylate(FOY) is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation.
iScience, 2024, 27(10):110862
Curr Res Chem Biol, 2022, 2:100023
Front Oncol, 2019, 0.87569444444
 Verified customer review of Gabexate Mesylate
S7218 Alvelestat (AZD9668) Alvelestat (AZD9668, Avelestat) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. Phase 2.
Cell Death Discov, 2025, 11(1):29
Int Immunopharmacol, 2025, 159:114860
Proc Natl Acad Sci U S A, 2021, 118(34)e2102435118
S8457 UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
PNAS Nexus, 2022, 1(3):pgac104
Front Genet, 2021, 12:651882
S7377 Aprotinin Aprotinin is a small protein serine protease inhibitor (Kd=0.06 pM for bovine β-trypsin), used to reduce perioperative blood loss and transfusion.
Front Cell Neurosci, 2025, 19:1623747
J Immunother Cancer, 2024, 12(11)e009805
Elife, 2021, 10e65962
E7249New Ulinastatin Ulinastatin (Uristatin) is the main inhibitor of a hydrolase protein and serine protease suppresses trypsin, chymotrypsin, and other pancreatic proteases. It can inhibit the production and release of inflammatory factors through mediating inflammatory pathways, while modulating apoptosis, enzyme activity, coagulation, and immune responses. It is effective in preventing and managing conditions like pancreatitis, cerebral edema, acute respiratory distress, circulatory failure, sepsis, and systemic inflammatory response syndrome.
S0042 Fulacimstat Fulacimstat (BAY1142524) is an orally available inhibitor of chymase with IC50 of 4 nM and 3 nM for human and hamster chymase enzyme, respectively.
S3511 FOY251 FOY251, an active metabolite of camostat mesilate, is an inhibitor of synthetic serine protease. FOY251 inhibits SARS-CoV-2 infection.
E1342 Sebetralstat Sebetralstat(KVD900) is a plasma kallikrien inhibitor.
E6013New Sivelestat sodium Sivelestat sodium (ONO-5046, Sodium sivelestat, LY544349 sodium) is a potent, specific, and intravenously active inhibitor of neutrophil elastase with an IC50 value of 44 nm. It is a useful agent for studying the roles of neutrophil elastase in animal disease models such as emphysema, adult respiratory distress syndrome, septic shock and disseminated intravascular coagulation in COVID-19.
E1014 Upamostat (WX-671) Upamostat (WX-671), a novel serine protease urokinase (uPA) inhibitor by inhibiting the urokinase-type plasminogen activator (uPA) system.
S0479 ZK824859 ZK824859 is a potent, selective and orally bioavailable inhibitor of urokinase plasminogen activator (uPA) with IC50 of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.
E7249New Ulinastatin Ulinastatin (Uristatin) is the main inhibitor of a hydrolase protein and serine protease suppresses trypsin, chymotrypsin, and other pancreatic proteases. It can inhibit the production and release of inflammatory factors through mediating inflammatory pathways, while modulating apoptosis, enzyme activity, coagulation, and immune responses. It is effective in preventing and managing conditions like pancreatitis, cerebral edema, acute respiratory distress, circulatory failure, sepsis, and systemic inflammatory response syndrome.
E6013New Sivelestat sodium Sivelestat sodium (ONO-5046, Sodium sivelestat, LY544349 sodium) is a potent, specific, and intravenously active inhibitor of neutrophil elastase with an IC50 value of 44 nm. It is a useful agent for studying the roles of neutrophil elastase in animal disease models such as emphysema, adult respiratory distress syndrome, septic shock and disseminated intravascular coagulation in COVID-19.

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