Acyltransferase

Inhibitory Selectivity

Acyltransferase Products

Catalog No. Information Product Use Citations Product Validations
S2187

Avasimibe

Avasimibe inhibits ACAT with IC50 of 3.3 μM, also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9 μM, 13.9 μM and 26.5 μM, respectively.

S3021

Rimonabant

Rimonabant is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane. Rimonabant is also a dual inhibitor of acyl CoA:cholesterol acyltransferases(ACAT) 1 and 2 and inhibits mycobacterial MmpL3.

S4189

Cyclandelate

Cyclandelate is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM.

S9162

Rubimaillin

Rubimaillin, found in the Chinese medical plant Rubia cordifola, is a dual inhibitor of ACAT1 and ACAT2, but is more selective for the ACAT2 isozyme.

Catalog No. Information Product Use Citations Product Validations
S2187

Avasimibe

Avasimibe inhibits ACAT with IC50 of 3.3 μM, also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9 μM, 13.9 μM and 26.5 μM, respectively.

S3021

Rimonabant

Rimonabant is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane. Rimonabant is also a dual inhibitor of acyl CoA:cholesterol acyltransferases(ACAT) 1 and 2 and inhibits mycobacterial MmpL3.

S4189

Cyclandelate

Cyclandelate is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM.

S9162

Rubimaillin

Rubimaillin, found in the Chinese medical plant Rubia cordifola, is a dual inhibitor of ACAT1 and ACAT2, but is more selective for the ACAT2 isozyme.

Tags: ACAT