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Acyltransferase Products

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  • Acyltransferase Inhibitors (13)
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Catalog No. Product Name Information Product Use Citations Product Validations
S2187 Avasimibe Avasimibe inhibits ACAT with IC50 of 3.3 μM, also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9 μM, 13.9 μM and 26.5 μM, respectively.
Hepatol Commun, 2025, 9(6)e0714
Nat Commun, 2024, 15(1):8301
J Virol, 2024, 98(11):e0110324
S7889 Xanthohumol Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and apoptosis in cancer cells. Phase 1.
J Cell Sci, 2024, 137(20)jcs262162
Antiviral Res, 2022, 207:105416
Oxid Med Cell Longev, 2022, 2022:9523491
S3021 Rimonabant (SR141716) Rimonabant (SR141716) is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane. Rimonabant is also a dual inhibitor of acyl CoA:cholesterol acyltransferases(ACAT) 1 and 2 and inhibits mycobacterial MmpL3.
Toxicol Lett, 2023, 374:48-56
Int J Biol Sci, 2022, 18(4):1401-1414
Mol Metab, 2022, 65:101597
S2674 A922500 A922500 (DGAT-1 Inhibitor 4a) is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets.
Cell Death Discov, 2025, 11(1):21
Nature, 2023, 621(7977):171-178
Nature, 2023, 621(7977):171-178
S7192 PF-04620110 PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
J Pharm Biomed Anal, 2019, 170:176-186
J Cell Biol, 2018, 217(3):975-995
S0820 RP-64477 RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). RP-64477 inhibits ACAT activity with IC50 of 113 nM, 503 nM, and 180 nM in human intestinal (CaCo-2), hepatic (HepG2) and monocytic (THP-1) cell assays, respectively.
S0359 T863 (DGAT-3) T863 (DGAT-3) is a potent, selective and orally active inhibitor of Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) tht acts on the acyl-CoA binding site of DGAT1 and inhibits DGAT1-mediated triacylglycerol formation in cells.
J Virol, 2024, 98(11):e0110324
J Cell Sci, 2024, 137(20)jcs262162
S4189 Cyclandelate Cyclandelate (BS 572,3,5,5-Trimethylcyclohexyl mandelate) is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM.
S9162 Rubimaillin Rubimaillin (Mollugin), found in the Chinese medical plant Rubia cordifola, is a dual inhibitor of acetyl-CoA cholesterol acyltransferase 1 (ACAT1) and acetyl-CoA cholesterol acyltransferase 2 (ACAT2), but is more selective for the ACAT2 isozyme.
E0941 K-604 dihydrochloride K-604 dihydrochloride, a potent and selective inhibitor of Acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1), suppresses the development of atherosclerosis in an animal model without affecting plasma cholesterol levels.
S9921 PF-06424439

PF-06424439 is a first orally bioavailable small-molecule inhibitor of DGAT2 with an IC50 of 14 nM.
E7561New Pradigastat Pradigastat (LCQ-908) is a potent and selective inhibitor of DGAT1 with an IC50 of 57 nM in hDGAT1. It also inhibits OATP1B1, OATP1B3 , and OAT3 activity in a concentration-dependent manner, with an IC50 of 1.66 μM, 3.34 μM, and 0.973 μM, respectively.
S6971 Ervogastat Ervogastat (PF-06865571, DGAT2i) is a potent diacylglycerol acyltransferase 2 (DGAT2) inhibitor that reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH).
S2187 Avasimibe Avasimibe inhibits ACAT with IC50 of 3.3 μM, also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9 μM, 13.9 μM and 26.5 μM, respectively.
Hepatol Commun, 2025, 9(6)e0714
Nat Commun, 2024, 15(1):8301
J Virol, 2024, 98(11):e0110324
S7889 Xanthohumol Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and apoptosis in cancer cells. Phase 1.
J Cell Sci, 2024, 137(20)jcs262162
Antiviral Res, 2022, 207:105416
Oxid Med Cell Longev, 2022, 2022:9523491
S3021 Rimonabant (SR141716) Rimonabant (SR141716) is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane. Rimonabant is also a dual inhibitor of acyl CoA:cholesterol acyltransferases(ACAT) 1 and 2 and inhibits mycobacterial MmpL3.
Toxicol Lett, 2023, 374:48-56
Int J Biol Sci, 2022, 18(4):1401-1414
Mol Metab, 2022, 65:101597
S2674 A922500 A922500 (DGAT-1 Inhibitor 4a) is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets.
Cell Death Discov, 2025, 11(1):21
Nature, 2023, 621(7977):171-178
Nature, 2023, 621(7977):171-178
S7192 PF-04620110 PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
J Pharm Biomed Anal, 2019, 170:176-186
J Cell Biol, 2018, 217(3):975-995
S0820 RP-64477 RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). RP-64477 inhibits ACAT activity with IC50 of 113 nM, 503 nM, and 180 nM in human intestinal (CaCo-2), hepatic (HepG2) and monocytic (THP-1) cell assays, respectively.
S0359 T863 (DGAT-3) T863 (DGAT-3) is a potent, selective and orally active inhibitor of Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) tht acts on the acyl-CoA binding site of DGAT1 and inhibits DGAT1-mediated triacylglycerol formation in cells.
J Virol, 2024, 98(11):e0110324
J Cell Sci, 2024, 137(20)jcs262162
S4189 Cyclandelate Cyclandelate (BS 572,3,5,5-Trimethylcyclohexyl mandelate) is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM.
S9162 Rubimaillin Rubimaillin (Mollugin), found in the Chinese medical plant Rubia cordifola, is a dual inhibitor of acetyl-CoA cholesterol acyltransferase 1 (ACAT1) and acetyl-CoA cholesterol acyltransferase 2 (ACAT2), but is more selective for the ACAT2 isozyme.
E0941 K-604 dihydrochloride K-604 dihydrochloride, a potent and selective inhibitor of Acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1), suppresses the development of atherosclerosis in an animal model without affecting plasma cholesterol levels.
S9921 PF-06424439

PF-06424439 is a first orally bioavailable small-molecule inhibitor of DGAT2 with an IC50 of 14 nM.
E7561New Pradigastat Pradigastat (LCQ-908) is a potent and selective inhibitor of DGAT1 with an IC50 of 57 nM in hDGAT1. It also inhibits OATP1B1, OATP1B3 , and OAT3 activity in a concentration-dependent manner, with an IC50 of 1.66 μM, 3.34 μM, and 0.973 μM, respectively.
S6971 Ervogastat Ervogastat (PF-06865571, DGAT2i) is a potent diacylglycerol acyltransferase 2 (DGAT2) inhibitor that reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH).
E7561New Pradigastat Pradigastat (LCQ-908) is a potent and selective inhibitor of DGAT1 with an IC50 of 57 nM in hDGAT1. It also inhibits OATP1B1, OATP1B3 , and OAT3 activity in a concentration-dependent manner, with an IC50 of 1.66 μM, 3.34 μM, and 0.973 μM, respectively.

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Tags: ACAT