Home Metabolism Aminopeptidase

Aminopeptidase

Aminopeptidases, a member of Zn2+-metalloenzyme including L-histidinol dehydrogenase and matrix metalloproteinases (MMP), is involved in the the formation of new blood vessels and can regulate the growth of tumor. Aminopeptidases can remove the NH2 terminal methionine of proteins and make a contribution of regulation of biologically active peptides. Aminopeptidases inhibitors can be antiproliferative effect on the different cell lines.

Other Metabolism Related Inhibitors

VEGFR EGFR c-Met CSF-1R IGF-1R c-Kit ALK Tie-2 HER2 c-RET Trk receptor
Cat.No. Product Name Information Product Use Citations Product Validations
S1522 Tosedostat (CHR2797) Tosedostat (CHR2797) is an aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N with IC50 of 100 nM, 150 nM and 220 nM, respectively, and does not effectively inhibit either PILSAP, MetAP-2, LTA4 hydrolase, or MetAP-2. Phase 2.
PLoS One, 2018, 13(1):e0190682
Integr Biol, 2014, 6(2):164-74
Anal Chem, 2013, 85(10):4991-7
E4916 Bestatin hydrochloride Bestatin hydrochloride is an inhibitor of aminopeptidase N and enkephalinase that elevates the levels of angiotensin II and angiotensin III. It also acts as a non-competitive inhibitor (α > 1) of porcine DPP-IV with a Ki value of 75 μM. It reduces DPP-IV activity, decreases cell viability, and increases DNA fragmentation in vitro. It has the potential to treat skin conditions like acne, psoriasis and keloids.
S9631 Puromycin aminonucleoside Puromycin aminonucleoside (NSC 3056, PAN, Stylomycin aminonucleoside, ARDMA, SAN), the aminonucleoside portion of the antibiotic puromycin, is a reversible inhibitor of dipeptidyl-peptidase II and cytosol alanyl aminopeptidase that induces apoptosis in mesangial cells (MCs) accompanied by declined cell viability and enhanced inflammatory response.This compound can be used to induce animal models of Kidney Disease.
PLoS Pathog, 2025, 21(9):e1013549
bioRxiv, 2025, 2025.08.15.670603
mBio, 2024, 15(12):e0194524