PREP

Metabolism

DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR Carbonic Anhydrase Hydroxylase Liver X Receptor FAAH Acyltransferase Dehydrogenase Phosphorylase PPAR CYP17 CETP FXR HMG-CoA Reductase Transferase IDO/TDO Retinoid Receptor Casein Kinase NAMPT phosphatase Lipase Lipoxygenase Thioredoxin Decarboxylase Vitamin Serine/threonin kinase LDL Fatty Acid Synthase FOX Glycogen synthesis PKM Glycolysis HDL Carbohydrate Metabolism ATP-citrate lyase Acetyl-CoA carboxylase CYP450 PCSK9 Leukotriene PDHK PGC-1α ROR FABP Peroxidases Aldose Reductase Xanthine Oxidase THR Epoxide Hydrolase PEP GTPCH FAO PAI-1 LDH SCD CPSase Mannosidase Thioredoxin Reductase SGK FTase γGCS CPT SREBP Mitochondrial Metabolism PARG Glucosylceramide Synthase Catalase 3-MST Serine hydrolase CAR glucocerebrosidase Mitochondrial pyruvate carrier GOT SHIP SOD LCN Endogenous Metabolite ATGL NMT Aconitase AGEs Amino Acids and Derivatives Amylase Drug Metabolite Glucokinase Glucosidase glycosidase GSNOR GST Hexokinase Isocitrate Dehydrogenase (IDH) Lipid Liposome LPL Receptor MAGL NEDD4-1 NPC1L1 PGK1 Reductase stilbene oxidase UGT

All (5)
PREP Inhibitors (5)
New PREP Products

Cat.No.	Product Name	Information	Product Use Citations
S2269	Baicalin	Baicalin is an inhibitor of prolyl oligopeptidase and also is an allosteric activator of carnitine palmityl transferase 1 (CPT1). This compound reduces the expression of NF-κB.	Front Pharmacol, 2025, 16:1563194 Ecotoxicol Environ Saf, 2024, 275:116262 Chem Biol Interact, 2024, 387:110820
S0842	SP-13786 (UAMC-1110)	SP-13786 (UAMC-1110)(compound 60) is a potent and selective inhibitor of fibroblast activation protein (FAP) and prolyl oligopeptidase (PREP) with IC50 of 3.2 nM and 1.8 μM, respectively.
S3249	Corypalmine	Corypalmine ((R)-(+)-Corypalmine), an alkaloid isolated from Stephania cepharantha, is an inhibitor of prolyl endopeptidase/oligopeptidase (PREP/POP) with IC50 of 128.0 μM.
S2268	Baicalein	Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.	SLAS Discov, 2024, S2472-5552(24)00007-8 Redox Rep, 2023, 28(1):2152607 Microbiol Spectr, 2023, 11(3):e0470222
S2396	Salidroside	Salidroside (Rhodioloside), a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties. This compound is a prolyl endopeptidase inhibitor. It alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. This chemical protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.	PLoS One, 2024, 19(7):e0306926 Mol Med Rep, 2023, 27(2)37 Research Square, 2023, 10.21203/rs.3.rs-3696850/v1
S2269	Baicalin	Baicalin is an inhibitor of prolyl oligopeptidase and also is an allosteric activator of carnitine palmityl transferase 1 (CPT1). This compound reduces the expression of NF-κB.	Front Pharmacol, 2025, 16:1563194 Ecotoxicol Environ Saf, 2024, 275:116262 Chem Biol Interact, 2024, 387:110820
S0842	SP-13786 (UAMC-1110)	SP-13786 (UAMC-1110)(compound 60) is a potent and selective inhibitor of fibroblast activation protein (FAP) and prolyl oligopeptidase (PREP) with IC50 of 3.2 nM and 1.8 μM, respectively.
S3249	Corypalmine	Corypalmine ((R)-(+)-Corypalmine), an alkaloid isolated from Stephania cepharantha, is an inhibitor of prolyl endopeptidase/oligopeptidase (PREP/POP) with IC50 of 128.0 μM.
S2268	Baicalein	Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.	SLAS Discov, 2024, S2472-5552(24)00007-8 Redox Rep, 2023, 28(1):2152607 Microbiol Spectr, 2023, 11(3):e0470222
S2396	Salidroside	Salidroside (Rhodioloside), a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties. This compound is a prolyl endopeptidase inhibitor. It alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. This chemical protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.	PLoS One, 2024, 19(7):e0306926 Mol Med Rep, 2023, 27(2)37 Research Square, 2023, 10.21203/rs.3.rs-3696850/v1