Cysteine Protease

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1115 Odanacatib (MK-0822) <1 mg/mL 100 mg/mL <1 mg/mL
S7379 E-64 11 mg/mL 71 mg/mL <1 mg/mL
S3025 PMSF <1 mg/mL 35 mg/mL 15 mg/mL
S7393 Aloxistatin(E64d) <1 mg/mL 68 mg/mL 68 mg/mL
S7420 CA-074 methyl ester (CA-074 Me) 0 mg/mL 79 mg/mL 79 mg/mL
S2847 Cathepsin Inhibitor 1 <1 mg/mL 80 mg/mL 50 mg/mL
S7396 Calpeptin <1 mg/mL 72 mg/mL 72 mg/mL
S7386 MG-101 (ALLN) <1 mg/mL 76 mg/mL 76 mg/mL
S7391 Z-FA-FMK <1 mg/mL 77 mg/mL 34 mg/mL
S7380 Leupeptin Hemisulfate 95 mg/mL 95 mg/mL 95 mg/mL
S7392 Loxistatin Acid (E-64C) 2 mg/mL 62 mg/mL 62 mg/mL
S3692 N-Ethylmaleimide (NEM) 25 mg/mL 25 mg/mL 25 mg/mL
S7424 PD 151746 <1 mg/mL 47 mg/mL 47 mg/mL
Catalog No. Information Product Use Citations Product Validations

Odanacatib (MK-0822)

Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3.



E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM.



PMSF is an irreversible serine/cysteine protease inhibitor.



Aloxistatin is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity.


CA-074 methyl ester (CA-074 Me)

CA-074 Me is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor.


Cathepsin Inhibitor 1

Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.



Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively.


MG-101 (ALLN)

MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.



Z-FA-FMK is an irreversible cysteine protease inhibitor, and also inhibits effector caspases.


Leupeptin Hemisulfate

Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.


Loxistatin Acid (E-64C)

Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.


N-Ethylmaleimide (NEM)

N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group.


PD 151746

PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain.