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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S3692 N-Ethylmaleimide (NEM) NEM (N-Ethylmaleimide) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group. N-Ethylmaleimide (NEM) inactivates endogenous deubiquitinating enzymes (DUBs). N-Ethylmaleimide (NEM) specifically inhibits phosphate transport in mitochondria.
Nat Commun, 2025, 16(1):7812
Inflammation, 2025, 10.1007/s10753-025-02273-w
Toxicol Lett, 2025, 406:31-37
E2899 MG132 SSS MG132 SSS(Z-Leu-Leu-Leu-al, MG132) is a potent proteasome and calpain inhibitor with IC50 of 100 nM and 1.2 μM, respectively.
Journal of Advanced Research, 2025, S2090-1232(25)00940-3
J Adv Res, 2025, S2090-1232(25)00940-3
Nature Communications, 2024, 244
S7396 Calpeptin Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. This compound attenuates apoptosis and intracellular inflammatory changes in muscle cells.
EMBO Mol Med, 2025, 17(12):3355-3376
Transl Psychiatry, 2025, 15(1):52
Mol Med, 2025, 31(1):166
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S1013 Bortezomib Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. This compound inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.
Cancer Res, 2026, 10.1158/0008-5472.CAN-25-4114.
J Cell Mol Med, 2026, 30(4):e71053
J Proteomics, 2026, 322:105536
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S7393 Aloxistatin (E-64d) Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, and aloxistatin treatment reduced cellular entry of SARS-CoV-2 pseudovirions by 92.3%.
PLoS Pathog, 2026, 22(2):e1013946
Nat Chem Biol, 2025, 10.1038/s41589-025-01907-2
J Exp Clin Cancer Res, 2025, 44(1):317
S1115 Odanacatib Odanacatib is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3.
Frontiers in Endocrinology, 2025, 16:1588394
PLoS One, 2025, 20(7):e0327246
Int Dent J, 2025, 75(4):100810
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S7379 E-64 E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM. This compound induces oxidative stress and apoptosis in Filarial Parasite.
Nat Commun, 2025, 16(1):5403
Elife, 2025, 14RP104057
bioRxiv, 2024, 2024.09.30.615241
S7386 MG-101 (ALLN) MG-101 (ALLN, Calpain inhibitor-1, Ac-LLnL-CHO) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
eLife, October 28, 2020, e58868
Preprints.org, February 24, 2026, nan
American Journal of Cancer Research, August 1, 2019, 1682-1694
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S7391 Z-FA-FMK Z-FA-FMK ((1S)-Z-FA-FMK) is an irreversible cysteine protease inhibitor, and also inhibits effector caspases.
Cell Reports, April 6, 2021, 108959
Eur J Med Chem, 2025, 300:118108
Cancer Res, 2022, can.21.4222
S2847 Cathepsin Inhibitor 1 Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
bioRxiv, 2025, 2025.09.08.674976
Cell Mol Life Sci, 2024, 81(1):442
Elife, 2023, 12e79144