Cysteine Protease

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1115 Odanacatib (MK-0822) <1 mg/mL 100 mg/mL <1 mg/mL
S7379 E-64 11 mg/mL 71 mg/mL <1 mg/mL
S3025 PMSF <1 mg/mL 35 mg/mL 15 mg/mL
S7393 Aloxistatin(E64d) <1 mg/mL 68 mg/mL 68 mg/mL
S7420 CA-074 methyl ester (CA-074 Me) 0 mg/mL 79 mg/mL 79 mg/mL
S2847 Cathepsin Inhibitor 1 <1 mg/mL 80 mg/mL 50 mg/mL
S7396 Calpeptin <1 mg/mL 72 mg/mL 72 mg/mL
S7386 MG-101 (ALLN) <1 mg/mL 76 mg/mL 76 mg/mL
S7391 Z-FA-FMK <1 mg/mL 77 mg/mL 34 mg/mL
S7380 Leupeptin Hemisulfate 95 mg/mL 95 mg/mL 95 mg/mL
S7392 Loxistatin Acid (E-64C) 2 mg/mL 62 mg/mL 62 mg/mL
S3692 N-Ethylmaleimide (NEM) 25 mg/mL 25 mg/mL 25 mg/mL
S7424 PD 151746 <1 mg/mL 47 mg/mL 47 mg/mL
Catalog No. Information Product Use Citations Product Validations
S1115

Odanacatib (MK-0822)

Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3.
J Bone Miner Res, 2015, 10.1002/jbmr.2520
J Dent Res, 2015, 10.1177/0022034515573964
Biochem J, 2017, 474(5):851-864
S7379

E-64

E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM.
Cell, 2018, 175(5):1336-1351
S3025

PMSF

PMSF is an irreversible serine/cysteine protease inhibitor.
S7393

Aloxistatin(E64d)

Aloxistatin is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity.
S7420

CA-074 methyl ester (CA-074 Me)

CA-074 Me is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor.
S2847

Cathepsin Inhibitor 1

Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.

S7396

Calpeptin

Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively.

Oncol Rep, 2017, 37(6):3651-3659
S7386

MG-101 (ALLN)

MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.

Graefes Arch Clin Exp Ophthalmol, 2018, 10.1007/s00417-018-4166-7
S7391

Z-FA-FMK

Z-FA-FMK is an irreversible cysteine protease inhibitor, and also inhibits effector caspases.
S7380

Leupeptin Hemisulfate

Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.
J Biol Chem, 2017, 292(15):6225-6239
S7392

Loxistatin Acid (E-64C)

Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
S3692

N-Ethylmaleimide (NEM)

N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group.

S7424

PD 151746

PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain.