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MMP Inhibitors

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S7157 Ilomastat (GM6001) Ilomastat (GM6001) is a broad spectrum matrix metalloprotease (MMP) inhibitor with Ki values of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, and 0.36 nM for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26, respectively.
Cell Commun Signal, 2025, 23(1):116
Int J Mol Sci, 2025, 26(7)3355
Ren Fail, 2025, 47(1):2499897
Verified customer review of Ilomastat (GM6001)
S7156 Marimastat (BB-2516) Marimastat (BB-2516, TA2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor with IC50 values of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7, respectively. This compound has reached Phase 3.
Cell Rep, 2025, 44(1):115193
Sci Rep, 2025, 15(1):13174
Nat Commun, 2024, 15(1):9473
Verified customer review of Marimastat (BB-2516)
S5159 Doxycycline Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor.
Nature, 2025, 10.1038/s41586-025-09222-5
Cell Stem Cell, 2025, S1934-5909(25)00181-X
Nat Commun, 2025, 16(1):7898
S7155 Batimastat (BB-94) Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. It also inhibits the activitity of other metalloproteases, such as ADAM17.
Cell Stem Cell, 2025, S1934-5909(25)00265-6
Br J Cancer, 2025, 10.1038/s41416-025-03181-4
iScience, 2025, 28(11):113682
Verified customer review of Batimastat (BB-94)
S7430 SB-3CT SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.
PeerJ, 2025, 13:e19550
Pharmacol Res, 2023, 190:106720
Kidney Int Rep, 2023, 8(9):1864-1874
Verified customer review of SB-3CT
S8966 T-5224 T-5224 is a selective inhibitor of transcription factor c-Fos/activator protein (AP)-1 with anti-inflammatory effects. T-5224 specifically inhibits the DNA binding activity of c-Fos/c-Jun and the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription.
MedComm (2020), 2025, 6(4):e70154
Cells, 2025, 14(7)474
iScience, 2025, 28(4):112176
S2333 Nobiletin Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities.
J Lipid Res, 2024, S0022-2275(24)00044-0
Nutrients, 2023, 15(18)3919
FASEB Bioadv, 2023, 5(2):62-70
Verified customer review of Nobiletin
S0769 MMP-9-IN-1 MMP-9-IN-1 (OUN87710) is a specific inhibitor of matrix metalloproteinase-9 (MMP-9). This compound selectively targets the hemopexin (PEX) domain of MMP-9 with Kd of 2.1 μM.
Pharmacol Res, 2024, 201:107088
Front Oncol, 2024, 14:1371342
Front Oncol, 2024, 14:1371307
S8072 NSC 405020 NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP.
Mol Oncol, 2024, 18(4):850-865
Mol Oncol, 2023, 10.1002/1878-0261.13440
Cell Rep, 2021, 37(4):109878
S5696 JNJ0966 JNJ0966 is a highly selective compound that inhibits activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. It has no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen.
Int J Mol Sci, 2023, 24(2)1293
Int J Med Sci, 2022, 19(1):47-64
Cell Rep, 2020, 30(6):1780-1797

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