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MMP Products

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MMP Inhibitors (28)
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New MMP Products

Catalog No.	Product Name	Information	Product Use Citations
E0073^New	CL-82198	CL-82198 is a selective, orally bioavailable MMP-13 inhibitor with an IC50 of 3.2 μM.
S0341	T-26c	T-26c is a highly potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13) with IC50 of 6.9 pM, more than 2600-fold selectivity over other related metalloenzymes.
S0752	AUDA	AUDA (compound 43) is a potent inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 18 nM and 69 nM for the mouse sEH and human sEH, respectively. AUDA has anti-inflammatory activity that reduces the protein expression of MMP-9, IL-1β, TNF-α and TGF-β. AUDA downregulates Smad3 and p38 signaling pathways.
S0769	MMP-9-IN-1	MMP-9-IN-1 (OUN87710) is a specific inhibitor of matrix metalloproteinase-9 (MMP-9). MMP-9-IN-1 selectively targets the hemopexin (PEX) domain of MMP-9 with Kd of 2.1 μM.	Epigenetics Chromatin, 2021, 14(1):23
S0923	Isoliquiritin apioside	Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.
S2333	Nobiletin (NSC 76751)	Nobiletin (NSC 76751, Hexamethoxyflavone), a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities.	FASEB J, 2022, 36(3):e22186 Cancer Biol Med, 2021, 18(1):227-244 J Nutr Biochem, 2021, S0955-2863(21)00308-9
S3309	Solasodine	Solasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK). Solasodine downregulates oncogenic microRNA-21 (miR-21), which has been known to target RECK. Solasodine also reduces PI3K/Akt signaling pathways and downregulates expression of miR-21.
S3590	Triolein	Triolein is an inhibitor of metalloproteinase-1 (MMP-1) and reduces both the expression of IL-6 and ROS generation in irradiated keratinocytes.
S3610	Cordycepin	Cordycepin (3'-Deoxyadenosine) is an adenosine analogue, which is readily phosphorylated to its mono-, di-, and triphosphate intracellularly. It has a very potent anti-cancer, anti-oxidant and anti-inflammatory activities.
S4163	Doxycycline Hyclate (WC2031)	Doxycycline Hyclate (WC2031, Doxycycline hydrochloride hemiethanolate hemihydrate) is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is also an inhibitor of matrix metallo-proteinases (MMP).	Cell Rep, 2022, 39(1):110643 Elife, 2022, 11e72483 Mol Cell, 2021, S1097-2765(21)00713-9
S4884	Trans-Zeatin	Trans-Zeatina ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing. Trans-Zeatin inhibits UVB-induced MMP-1 expression, c-Jun activation and phosphorylation of ERK, JNK and p38 MAP kinases (MAPKs) dose-dependently.
S4964	Lactobionic acid	Lactobionic acid (Galactosylgluconic acid), an α-hydroxyacid (AHA) with antioxidation activity, is used in the development of cosmeceuticals for skin. Lactobionic acid inhibits matrix-metalloproteinase (MMP) activity.	Mol Cancer Ther, 2019, 18(11):2097-2110
S5159	Doxycycline	Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor.	Mol Cancer, 2022, 21(1):43 EMBO Rep, 2022, e52984 Cell Rep, 2022, 39(1):110643
S5465	Morroniside	Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption. Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.
S5543	1, 10-Phenanthroline monohydrate	1,10-Phenanthroline is a classic chelating bidentate ligand for transition metal ions that has played an important role in the development of coordination chemistry. It is an inhibitor of metallopeptidases.	Int Immunopharmacol, 2022, 106:108578
S5696	JNJ0966	JNJ0966 is a highly selective compound that inhibits activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. It has no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen.	Int J Med Sci, 2022, 19(1):47-64 Cell Rep, 2020, 30(6):1780-1797
S5752	Abametapir	Abametapir (HA-44, BRN 0123183), the active ingredient of Xeglyze Lotion, is an inhibitor of metalloproteinases critical for louse survival and egg development.	Evid Based Complement Alternat Med, 2019, 2019:3648685
S6830	o-Phenanthroline	o-Phenanthroline (1,10-Phenanthroline, phen), a hypoxia-mimicking agent, is a non-specific matrix metalloproteinase (MMP) inhibitor with IC50 of 110.5μM for Collagenase. O-phenanthroline reduces the expression of MMP3 and MMP13 mRNA levels during chondrogenic differentiation of human chondrocytes (hChs), as well as after TNFα/IL-1β exposure in an explant model. o-Phenanthroline is also a metal chelator which prevents the induction of chromosomal aberrations in streptozotocin-treated cells and forms a red chelate with Fe2+ that absorbs maximally at 510 nm.	Chem Res Toxicol, 2018, 31(2):127-136 Chem Res Toxicol, 2018, 31(2):127-136
S7155	Batimastat (BB-94)	Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17.	Dev Cell, 2022, S1534-5807(22)00040-5 Int J Oral Sci, 2022, 14(1):6 Front Immunol, 2021, 12:752466
S7156	Marimastat (BB-2516)	Marimastat (BB-2516, TA2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 with IC50 of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM, respectively. Phase 3.	Cancer Res, 2022, canres.CAN-21-2576-E.2021 J Biol Chem, 2022, 298(4):101748 Cell Rep, 2021, 37(4):109878
S7157	Ilomastat (GM6001, Galardin)	Ilomastat (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with K_i of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively.	Sci Transl Med, 2021, 13(598)eabd4550 Clin Cancer Res, 2021, clincanres.1546.2021 EMBO Mol Med, 2021, e14059
S7430	SB-3CT	SB-3CT is an effective and selective gelatinase inhibitor with K_i of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.	Int J Mol Sci, 2022, 23(5)2793 J Neurosci, 2022, 42(1):16-32 Front Immunol, 2021, 12:752466
S7434	TAPI-1	TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP).	FASEB J, 2022, 36(3):e22234 Proc Natl Acad Sci U S A, 2021, 118(32)e2026123118 EMBO Mol Med, 2020, 7;12(2):e10154
S8072	NSC 405020	NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP.	Cell Rep, 2021, 37(4):109878 Front Plant Sci, 2021, 12:735328 Elife, 2018, 7
S8966	T-5224	T-5224 is a selective inhibitor of transcription factor c-Fos/activator protein (AP)-1 with anti-inflammatory effects. T-5224 specifically inhibits the DNA binding activity of c-Fos/c-Jun and the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription.	Theranostics, 2021, 11(14):7110-7125 Endocrinology, 2021, bqab207 Nat Commun, 2020, 11(1):5079
S9052	Auraptene	Auraptene (7-geranyloxycoumarin) is a natural coumarin derived from citrus plants and possesses valuable pharmacological properties, including anticarcinogenic, anti-inflammatory, antihelicobacter, antigenotoxic, and neuroprotective effects. Auraptene inhibits matrix metalloproteinase 2 (MMP-2) as well as key inflammatory mediators, including IL-6, IL-8 and chemokine (C-C motif) ligand-5(CCL5).
S9386	Polygalacic acid	Polygalacic acid is the triterpenoid tetrahydroxyacid isolated from Polygala paenea L.. Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13 and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner.
S9909^New	ARP 100	ARP 100 (MMP-2 Inhibitor III, Compound 10a) is a potent and selective inhibitor of MMP-2 with an IC50 of 12 nM and displays less inhibitory activity at MMP-9, MMP-3, MMP-1 and MMP-7 with IC50s of 200 nM, 4500 nM, >50,000 nM and >50,000 nM respectively.
S3288	Absinthin	Absinthin (Absynthine) is a naturally produced triterpene lactone from Artemisia absinthium with anti-inflammatory properties. Absinthin significantly enhances the expression of matrix metalloproteinase-8 (MMP-8) and is a possible treatment candidate for Acute lung injury (ALI).
S3781	Ginkgolide C	Ginkgolide C (BN-52022), isolated from Ginkgo biloba leaves, is a flavone reported to have multiple biological functions, from decreased platelet aggregation to ameliorating Alzheimer disease. It is an activator of MMP-9.	Biomed Pharmacother, 2021, 144:112325
E0073^New	CL-82198	CL-82198 is a selective, orally bioavailable MMP-13 inhibitor with an IC50 of 3.2 μM.
S0341	T-26c	T-26c is a highly potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13) with IC50 of 6.9 pM, more than 2600-fold selectivity over other related metalloenzymes.
S0752	AUDA	AUDA (compound 43) is a potent inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 18 nM and 69 nM for the mouse sEH and human sEH, respectively. AUDA has anti-inflammatory activity that reduces the protein expression of MMP-9, IL-1β, TNF-α and TGF-β. AUDA downregulates Smad3 and p38 signaling pathways.
S0769	MMP-9-IN-1	MMP-9-IN-1 (OUN87710) is a specific inhibitor of matrix metalloproteinase-9 (MMP-9). MMP-9-IN-1 selectively targets the hemopexin (PEX) domain of MMP-9 with Kd of 2.1 μM.	Epigenetics Chromatin, 2021, 14(1):23
S0923	Isoliquiritin apioside	Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.
S2333	Nobiletin (NSC 76751)	Nobiletin (NSC 76751, Hexamethoxyflavone), a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities.	FASEB J, 2022, 36(3):e22186 Cancer Biol Med, 2021, 18(1):227-244 J Nutr Biochem, 2021, S0955-2863(21)00308-9
S3309	Solasodine	Solasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK). Solasodine downregulates oncogenic microRNA-21 (miR-21), which has been known to target RECK. Solasodine also reduces PI3K/Akt signaling pathways and downregulates expression of miR-21.
S3590	Triolein	Triolein is an inhibitor of metalloproteinase-1 (MMP-1) and reduces both the expression of IL-6 and ROS generation in irradiated keratinocytes.
S3610	Cordycepin	Cordycepin (3'-Deoxyadenosine) is an adenosine analogue, which is readily phosphorylated to its mono-, di-, and triphosphate intracellularly. It has a very potent anti-cancer, anti-oxidant and anti-inflammatory activities.
S4163	Doxycycline Hyclate (WC2031)	Doxycycline Hyclate (WC2031, Doxycycline hydrochloride hemiethanolate hemihydrate) is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is also an inhibitor of matrix metallo-proteinases (MMP).	Cell Rep, 2022, 39(1):110643 Elife, 2022, 11e72483 Mol Cell, 2021, S1097-2765(21)00713-9
S4884	Trans-Zeatin	Trans-Zeatina ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing. Trans-Zeatin inhibits UVB-induced MMP-1 expression, c-Jun activation and phosphorylation of ERK, JNK and p38 MAP kinases (MAPKs) dose-dependently.
S4964	Lactobionic acid	Lactobionic acid (Galactosylgluconic acid), an α-hydroxyacid (AHA) with antioxidation activity, is used in the development of cosmeceuticals for skin. Lactobionic acid inhibits matrix-metalloproteinase (MMP) activity.	Mol Cancer Ther, 2019, 18(11):2097-2110
S5159	Doxycycline	Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor.	Mol Cancer, 2022, 21(1):43 EMBO Rep, 2022, e52984 Cell Rep, 2022, 39(1):110643
S5465	Morroniside	Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption. Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.
S5543	1, 10-Phenanthroline monohydrate	1,10-Phenanthroline is a classic chelating bidentate ligand for transition metal ions that has played an important role in the development of coordination chemistry. It is an inhibitor of metallopeptidases.	Int Immunopharmacol, 2022, 106:108578
S5696	JNJ0966	JNJ0966 is a highly selective compound that inhibits activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. It has no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen.	Int J Med Sci, 2022, 19(1):47-64 Cell Rep, 2020, 30(6):1780-1797
S5752	Abametapir	Abametapir (HA-44, BRN 0123183), the active ingredient of Xeglyze Lotion, is an inhibitor of metalloproteinases critical for louse survival and egg development.	Evid Based Complement Alternat Med, 2019, 2019:3648685
S6830	o-Phenanthroline	o-Phenanthroline (1,10-Phenanthroline, phen), a hypoxia-mimicking agent, is a non-specific matrix metalloproteinase (MMP) inhibitor with IC50 of 110.5μM for Collagenase. O-phenanthroline reduces the expression of MMP3 and MMP13 mRNA levels during chondrogenic differentiation of human chondrocytes (hChs), as well as after TNFα/IL-1β exposure in an explant model. o-Phenanthroline is also a metal chelator which prevents the induction of chromosomal aberrations in streptozotocin-treated cells and forms a red chelate with Fe2+ that absorbs maximally at 510 nm.	Chem Res Toxicol, 2018, 31(2):127-136 Chem Res Toxicol, 2018, 31(2):127-136
S7155	Batimastat (BB-94)	Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17.	Dev Cell, 2022, S1534-5807(22)00040-5 Int J Oral Sci, 2022, 14(1):6 Front Immunol, 2021, 12:752466
S7156	Marimastat (BB-2516)	Marimastat (BB-2516, TA2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 with IC50 of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM, respectively. Phase 3.	Cancer Res, 2022, canres.CAN-21-2576-E.2021 J Biol Chem, 2022, 298(4):101748 Cell Rep, 2021, 37(4):109878
S7157	Ilomastat (GM6001, Galardin)	Ilomastat (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with K_i of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively.	Sci Transl Med, 2021, 13(598)eabd4550 Clin Cancer Res, 2021, clincanres.1546.2021 EMBO Mol Med, 2021, e14059
S7430	SB-3CT	SB-3CT is an effective and selective gelatinase inhibitor with K_i of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.	Int J Mol Sci, 2022, 23(5)2793 J Neurosci, 2022, 42(1):16-32 Front Immunol, 2021, 12:752466
S7434	TAPI-1	TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP).	FASEB J, 2022, 36(3):e22234 Proc Natl Acad Sci U S A, 2021, 118(32)e2026123118 EMBO Mol Med, 2020, 7;12(2):e10154
S8072	NSC 405020	NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP.	Cell Rep, 2021, 37(4):109878 Front Plant Sci, 2021, 12:735328 Elife, 2018, 7
S8966	T-5224	T-5224 is a selective inhibitor of transcription factor c-Fos/activator protein (AP)-1 with anti-inflammatory effects. T-5224 specifically inhibits the DNA binding activity of c-Fos/c-Jun and the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription.	Theranostics, 2021, 11(14):7110-7125 Endocrinology, 2021, bqab207 Nat Commun, 2020, 11(1):5079
S9052	Auraptene	Auraptene (7-geranyloxycoumarin) is a natural coumarin derived from citrus plants and possesses valuable pharmacological properties, including anticarcinogenic, anti-inflammatory, antihelicobacter, antigenotoxic, and neuroprotective effects. Auraptene inhibits matrix metalloproteinase 2 (MMP-2) as well as key inflammatory mediators, including IL-6, IL-8 and chemokine (C-C motif) ligand-5(CCL5).
S9386	Polygalacic acid	Polygalacic acid is the triterpenoid tetrahydroxyacid isolated from Polygala paenea L.. Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13 and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner.
S9909^New	ARP 100	ARP 100 (MMP-2 Inhibitor III, Compound 10a) is a potent and selective inhibitor of MMP-2 with an IC50 of 12 nM and displays less inhibitory activity at MMP-9, MMP-3, MMP-1 and MMP-7 with IC50s of 200 nM, 4500 nM, >50,000 nM and >50,000 nM respectively.
S3288	Absinthin	Absinthin (Absynthine) is a naturally produced triterpene lactone from Artemisia absinthium with anti-inflammatory properties. Absinthin significantly enhances the expression of matrix metalloproteinase-8 (MMP-8) and is a possible treatment candidate for Acute lung injury (ALI).
S3781	Ginkgolide C	Ginkgolide C (BN-52022), isolated from Ginkgo biloba leaves, is a flavone reported to have multiple biological functions, from decreased platelet aggregation to ameliorating Alzheimer disease. It is an activator of MMP-9.	Biomed Pharmacother, 2021, 144:112325
E0073^New	CL-82198	CL-82198 is a selective, orally bioavailable MMP-13 inhibitor with an IC50 of 3.2 μM.
S9909^New	ARP 100	ARP 100 (MMP-2 Inhibitor III, Compound 10a) is a potent and selective inhibitor of MMP-2 with an IC50 of 12 nM and displays less inhibitory activity at MMP-9, MMP-3, MMP-1 and MMP-7 with IC50s of 200 nM, 4500 nM, >50,000 nM and >50,000 nM respectively.