JNJ0966

Catalog No.S5696

For research use only.

JNJ0966 is a highly selective compound that inhibits activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. It has no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen.

JNJ0966 Chemical Structure

CAS No. 315705-75-0

Selleck's JNJ0966 has been cited by 2 Publications

Purity & Quality Control

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Biological Activity

Description JNJ0966 is a highly selective compound that inhibits activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. It has no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen.
In vitro

JNJ0966 inhibits the conversion of proMMP-9 to active MMP-9 but is not a direct inhibitor of MMP-9 or MMP-3 enzymatic activity. JNJ0966 inhibits proMMP-9 maturation[1].

In vivo Oral administration of JNJ0966 significantly diminishes the clinical disease score observed in the mouse EAE model[1].

Protocol (from reference)

Animal Research:

[1]

  • Animal Models: mouse EAE model (conducted in female C57Bl/6 mice age 6-8 weeks)
  • Dosages: 10 and 30 mg/kg
  • Administration: by oral gavage

Solubility (25°C)

In vitro

DMSO 72 mg/mL
(199.75 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 360.45
Formula

C16H16N4O2S2

CAS No. 315705-75-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(SC(=N1)NC(=O)C)C2=CSC(=N2)NC3=CC=CC=C3OC

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

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% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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